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Trace minerals status and antioxidant enzymes activities in calves with dermatophytosis.
Biol Trace Elem Res. 2010 Jul; 136(1):40-7.BT

Abstract

The aim of this study was to determine the levels of trace minerals Zn, Cu, and Se, the effect of dermatophytosis on the level of thiobarbituric acid reactive substances (TBARS) as an indicator of lipid peroxidation, the status of enzymatic and nonenzymatic antioxidants, and the relationship between the mentioned trace minerals and antioxidant defense system in calves with dermatophytosis. A total of 21 Holstein calves with clinically established diagnosis of dermatophytosis and an equal number of healthy ones were included in this study. Results showed that 81% of mycotic isolates were Trichophyton verrucosum, while 19% were Trichophyton mentagrophytes. The level of Zn, Cu, Se, and glutathione (GSH) and the activity of the antioxidant enzymes, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were significantly (P <or= 0.05) lower. The plasma level of TBARS was significantly (P <or= 0.05) higher in dermatophytic calves compared to healthy controls. SOD activity was fairly correlated with serum Cu and positively correlated with serum Zn in healthy control (r = 0.68, P <or= 0.05; r = 0.58, P <or= 0.05) and in calves affected with dermatophytosis (r = 0.73, P <or= 0.05; r = 0.55, P <or= 0.05), respectively. GSH-Px activity was highly correlated with whole blood selenium (r = 0.78, P <or= 0.05) in healthy control and dermatophytic subjects (r = 0.76, P <or= 0.05). Our results demonstrated that in dermatophytosis, the alteration in the antioxidant enzyme activities might be secondary to changes in their cofactor concentrations.

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Authors+Show Affiliations

Al-Qudah KM
Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan. alqudah@just.edu.jo
Gharaibeh AA
No affiliation info available
Al-Shyyab MM
No affiliation info available

MeSH

AnimalsAntioxidantsCopperGlutathioneGlutathione PeroxidaseLipid PeroxidationSeleniumSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesTineaTrace ElementsTrichophytonZinc

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19777167

Citation

Al-Qudah, Khaled M., et al. "Trace Minerals Status and Antioxidant Enzymes Activities in Calves With Dermatophytosis." Biological Trace Element Research, vol. 136, no. 1, 2010, pp. 40-7.
Al-Qudah KM, Gharaibeh AA, Al-Shyyab MM. Trace minerals status and antioxidant enzymes activities in calves with dermatophytosis. Biol Trace Elem Res. 2010;136(1):40-7.
Al-Qudah, K. M., Gharaibeh, A. A., & Al-Shyyab, M. M. (2010). Trace minerals status and antioxidant enzymes activities in calves with dermatophytosis. Biological Trace Element Research, 136(1), 40-7. https://doi.org/10.1007/s12011-009-8525-4
Al-Qudah KM, Gharaibeh AA, Al-Shyyab MM. Trace Minerals Status and Antioxidant Enzymes Activities in Calves With Dermatophytosis. Biol Trace Elem Res. 2010;136(1):40-7. PubMed PMID: 19777167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace minerals status and antioxidant enzymes activities in calves with dermatophytosis. AU - Al-Qudah,Khaled M, AU - Gharaibeh,Ahmad A, AU - Al-Shyyab,Maysa'a M, Y1 - 2009/09/24/ PY - 2009/06/04/received PY - 2009/09/14/accepted PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/8/7/medline SP - 40 EP - 7 JF - Biological trace element research JO - Biol Trace Elem Res VL - 136 IS - 1 N2 - The aim of this study was to determine the levels of trace minerals Zn, Cu, and Se, the effect of dermatophytosis on the level of thiobarbituric acid reactive substances (TBARS) as an indicator of lipid peroxidation, the status of enzymatic and nonenzymatic antioxidants, and the relationship between the mentioned trace minerals and antioxidant defense system in calves with dermatophytosis. A total of 21 Holstein calves with clinically established diagnosis of dermatophytosis and an equal number of healthy ones were included in this study. Results showed that 81% of mycotic isolates were Trichophyton verrucosum, while 19% were Trichophyton mentagrophytes. The level of Zn, Cu, Se, and glutathione (GSH) and the activity of the antioxidant enzymes, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were significantly (P <or= 0.05) lower. The plasma level of TBARS was significantly (P <or= 0.05) higher in dermatophytic calves compared to healthy controls. SOD activity was fairly correlated with serum Cu and positively correlated with serum Zn in healthy control (r = 0.68, P <or= 0.05; r = 0.58, P <or= 0.05) and in calves affected with dermatophytosis (r = 0.73, P <or= 0.05; r = 0.55, P <or= 0.05), respectively. GSH-Px activity was highly correlated with whole blood selenium (r = 0.78, P <or= 0.05) in healthy control and dermatophytic subjects (r = 0.76, P <or= 0.05). Our results demonstrated that in dermatophytosis, the alteration in the antioxidant enzyme activities might be secondary to changes in their cofactor concentrations. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/19777167/Trace_minerals_status_and_antioxidant_enzymes_activities_in_calves_with_dermatophytosis_ L2 - https://dx.doi.org/10.1007/s12011-009-8525-4 DB - PRIME DP - Unbound Medicine ER -