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A comparison of the effects of caffeine following abstinence and normal caffeine use.
Psychopharmacology (Berl) 2009; 207(3):423-31P

Abstract

RATIONALE

Caffeine typically produces positive effects on mood and performance. However, tolerance may develop following habitual use, and abrupt cessation can result in withdrawal symptoms, such as fatigue. This study investigated whether caffeine has a greater stimulant effect in a withdrawn state compared to a normal caffeinated state, among moderate daily caffeine consumers.

MATERIALS AND METHODS

Using a within-subjects design, 17 caffeine consumers (mean +/- sd = 375 +/- 101 mg/day) ingested placebo or caffeine (250 mg) following 30-h of caffeine abstention or normal dietary caffeine use on four separate days. Self-reported mood and performance on choice reaction time, selective attention, and memory tasks were measured.

RESULTS

Caffeine had a greater effect on mood and choice reaction time in the abstained state than in the normal caffeinated state, but caffeine improved selective attention and memory in both states.

CONCLUSIONS

Although improvements in mood and reaction time may best explained as relief from withdrawal symptoms, other performance measures showed no evidence of withdrawal and were equally sensitive to an acute dose of caffeine in the normal caffeinated state.

Authors+Show Affiliations

Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19777214

Citation

Addicott, Merideth A., and Paul J. Laurienti. "A Comparison of the Effects of Caffeine Following Abstinence and Normal Caffeine Use." Psychopharmacology, vol. 207, no. 3, 2009, pp. 423-31.
Addicott MA, Laurienti PJ. A comparison of the effects of caffeine following abstinence and normal caffeine use. Psychopharmacology (Berl). 2009;207(3):423-31.
Addicott, M. A., & Laurienti, P. J. (2009). A comparison of the effects of caffeine following abstinence and normal caffeine use. Psychopharmacology, 207(3), pp. 423-31. doi:10.1007/s00213-009-1668-3.
Addicott MA, Laurienti PJ. A Comparison of the Effects of Caffeine Following Abstinence and Normal Caffeine Use. Psychopharmacology (Berl). 2009;207(3):423-31. PubMed PMID: 19777214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the effects of caffeine following abstinence and normal caffeine use. AU - Addicott,Merideth A, AU - Laurienti,Paul J, Y1 - 2009/09/24/ PY - 2009/02/16/received PY - 2009/09/05/accepted PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/3/24/medline SP - 423 EP - 31 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 207 IS - 3 N2 - RATIONALE: Caffeine typically produces positive effects on mood and performance. However, tolerance may develop following habitual use, and abrupt cessation can result in withdrawal symptoms, such as fatigue. This study investigated whether caffeine has a greater stimulant effect in a withdrawn state compared to a normal caffeinated state, among moderate daily caffeine consumers. MATERIALS AND METHODS: Using a within-subjects design, 17 caffeine consumers (mean +/- sd = 375 +/- 101 mg/day) ingested placebo or caffeine (250 mg) following 30-h of caffeine abstention or normal dietary caffeine use on four separate days. Self-reported mood and performance on choice reaction time, selective attention, and memory tasks were measured. RESULTS: Caffeine had a greater effect on mood and choice reaction time in the abstained state than in the normal caffeinated state, but caffeine improved selective attention and memory in both states. CONCLUSIONS: Although improvements in mood and reaction time may best explained as relief from withdrawal symptoms, other performance measures showed no evidence of withdrawal and were equally sensitive to an acute dose of caffeine in the normal caffeinated state. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/19777214/A_comparison_of_the_effects_of_caffeine_following_abstinence_and_normal_caffeine_use_ L2 - https://dx.doi.org/10.1007/s00213-009-1668-3 DB - PRIME DP - Unbound Medicine ER -