Tags

Type your tag names separated by a space and hit enter

The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia.
Cancer Causes Control 2010; 21(1):51-9CC

Abstract

We evaluated the relationship between the dietary intake of vegetables and fruits, and the risk of cervical intraepithelial neoplasia (CIN) and determined whether these associations were modified by human papillomavirus (HPV) viral load. We enrolled 1,096 women aged 18-65 to participate in a HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls, 90 CIN I and 72 CIN II/III). The multivariate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated by multinomial logistic methods. After controlling for potential confounders, we found that a higher HPV viral load was associated with an increased risk of CIN I (OR = 2.68, 95% CI, 1.19-6.04) and CIN II/III (OR = 2.78, 95% CI, 1.15-6.72). The relationships between HPV infection, dietary intake of vegetables and fruits and risk of CIN were not statistically significant. However, subjects with lower intake of vegetables and fruits, and a higher viral load (> or =15.5) have a higher risk of CIN II/III (OR = 2.84(1.26-6.42), interaction p = 0.06 for vegetables; OR = 2.93(1.25-6.87), interaction p = 0.01 for fruits), compared with subjects with lower intake of vegetables and fruits, and a lower viral load (<15.5). Our findings suggest that the dietary intake of vegetables and fruits is associated with the progression of cervical carcinogenesis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19777358

Citation

Hwang, Jong Ha, et al. "The Association Between Fruit and Vegetable Consumption and HPV Viral Load in High-risk HPV-positive Women With Cervical Intraepithelial Neoplasia." Cancer Causes & Control : CCC, vol. 21, no. 1, 2010, pp. 51-9.
Hwang JH, Lee JK, Kim TJ, et al. The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia. Cancer Causes Control. 2010;21(1):51-9.
Hwang, J. H., Lee, J. K., Kim, T. J., & Kim, M. K. (2010). The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia. Cancer Causes & Control : CCC, 21(1), pp. 51-9. doi:10.1007/s10552-009-9433-9.
Hwang JH, et al. The Association Between Fruit and Vegetable Consumption and HPV Viral Load in High-risk HPV-positive Women With Cervical Intraepithelial Neoplasia. Cancer Causes Control. 2010;21(1):51-9. PubMed PMID: 19777358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia. AU - Hwang,Jong Ha, AU - Lee,Jae Kwan, AU - Kim,Tae Jin, AU - Kim,Mi Kyung, Y1 - 2009/09/24/ PY - 2009/02/02/received PY - 2009/09/09/accepted PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/5/14/medline SP - 51 EP - 9 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 21 IS - 1 N2 - We evaluated the relationship between the dietary intake of vegetables and fruits, and the risk of cervical intraepithelial neoplasia (CIN) and determined whether these associations were modified by human papillomavirus (HPV) viral load. We enrolled 1,096 women aged 18-65 to participate in a HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls, 90 CIN I and 72 CIN II/III). The multivariate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated by multinomial logistic methods. After controlling for potential confounders, we found that a higher HPV viral load was associated with an increased risk of CIN I (OR = 2.68, 95% CI, 1.19-6.04) and CIN II/III (OR = 2.78, 95% CI, 1.15-6.72). The relationships between HPV infection, dietary intake of vegetables and fruits and risk of CIN were not statistically significant. However, subjects with lower intake of vegetables and fruits, and a higher viral load (> or =15.5) have a higher risk of CIN II/III (OR = 2.84(1.26-6.42), interaction p = 0.06 for vegetables; OR = 2.93(1.25-6.87), interaction p = 0.01 for fruits), compared with subjects with lower intake of vegetables and fruits, and a lower viral load (<15.5). Our findings suggest that the dietary intake of vegetables and fruits is associated with the progression of cervical carcinogenesis. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19777358/The_association_between_fruit_and_vegetable_consumption_and_HPV_viral_load_in_high_risk_HPV_positive_women_with_cervical_intraepithelial_neoplasia_ L2 - https://doi.org/10.1007/s10552-009-9433-9 DB - PRIME DP - Unbound Medicine ER -