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Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review.
World J Gastroenterol 2009; 15(36):4481-90WJ

Abstract

We systematically reviewed the clinical trials which recruited antioxidants in the therapy of pancreatitis and evaluated whether antioxidants improve the outcome of patients with pancreatitis. Electronic bibliographic databases were searched for any studies which investigated the use of antioxidants in the management of acute pancreatitis (AP) or chronic pancreatitis (CP) and in the prevention of post-endoscopic retrograde cholangio-pancreatography (post-ERCP) pancreatitis (PEP) up to February 2009. Twenty-two randomized, placebo-controlled, clinical trials met our criteria and were included in the review. Except for a cocktail of antioxidants which showed improvement in outcomes in three different clinical trials, the results of the administration of other antioxidants in both AP and CP clinical trials were incongruent and heterogeneous. Furthermore, antioxidant therapy including allopurinol and N-acetylcysteine failed to prevent the onset of PEP in almost all trials. In conclusion, the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP, CP or PEP. Further double blind, randomized, placebo-controlled clinical trials with large sample size need to be conducted.

Pub Type(s)

Editorial
Review
Systematic Review

Language

eng

PubMed ID

19777606

Citation

Mohseni Salehi Monfared, Seyed Sajad, et al. "Antioxidant Therapy in the Management of Acute, Chronic and post-ERCP Pancreatitis: a Systematic Review." World Journal of Gastroenterology, vol. 15, no. 36, 2009, pp. 4481-90.
Mohseni Salehi Monfared SS, Vahidi H, Abdolghaffari AH, et al. Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review. World J Gastroenterol. 2009;15(36):4481-90.
Mohseni Salehi Monfared, S. S., Vahidi, H., Abdolghaffari, A. H., Nikfar, S., & Abdollahi, M. (2009). Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review. World Journal of Gastroenterology, 15(36), pp. 4481-90.
Mohseni Salehi Monfared SS, et al. Antioxidant Therapy in the Management of Acute, Chronic and post-ERCP Pancreatitis: a Systematic Review. World J Gastroenterol. 2009 Sep 28;15(36):4481-90. PubMed PMID: 19777606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review. AU - Mohseni Salehi Monfared,Seyed Sajad, AU - Vahidi,Hamed, AU - Abdolghaffari,Amir Hossein, AU - Nikfar,Shekoufeh, AU - Abdollahi,Mohammad, PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2009/11/5/medline SP - 4481 EP - 90 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 15 IS - 36 N2 - We systematically reviewed the clinical trials which recruited antioxidants in the therapy of pancreatitis and evaluated whether antioxidants improve the outcome of patients with pancreatitis. Electronic bibliographic databases were searched for any studies which investigated the use of antioxidants in the management of acute pancreatitis (AP) or chronic pancreatitis (CP) and in the prevention of post-endoscopic retrograde cholangio-pancreatography (post-ERCP) pancreatitis (PEP) up to February 2009. Twenty-two randomized, placebo-controlled, clinical trials met our criteria and were included in the review. Except for a cocktail of antioxidants which showed improvement in outcomes in three different clinical trials, the results of the administration of other antioxidants in both AP and CP clinical trials were incongruent and heterogeneous. Furthermore, antioxidant therapy including allopurinol and N-acetylcysteine failed to prevent the onset of PEP in almost all trials. In conclusion, the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP, CP or PEP. Further double blind, randomized, placebo-controlled clinical trials with large sample size need to be conducted. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/19777606/Antioxidant_therapy_in_the_management_of_acute_chronic_and_post_ERCP_pancreatitis:_a_systematic_review_ L2 - http://www.wjgnet.com/1007-9327/full/v15/i36/4481.htm DB - PRIME DP - Unbound Medicine ER -