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Cytotoxic acacic acid glycosides from the roots of Albizia coriaria.
J Nat Prod. 2009 Oct; 72(10):1725-30.JN

Abstract

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Noté OP
Laboratoire de Pharmacognosie, UMIB, EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne D'Arc, BP 87900, 21079 Dijon Cedex, France.
Mitaine-Offer AC
No affiliation info available
Miyamoto T
No affiliation info available
Paululat T
No affiliation info available
Mirjolet JF
No affiliation info available
Duchamp O
No affiliation info available
Pegnyemb DE
No affiliation info available
Lacaille-Dubois MA
No affiliation info available

MeSH

AlbizziaAntineoplastic Agents, PhytogenicCameroonDrug Screening Assays, AntitumorHCT116 CellsHT29 CellsHumansMolecular StructureNuclear Magnetic Resonance, BiomolecularOleanolic AcidPlant RootsPlants, MedicinalSaponinsTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19778067

Citation

Noté, Olivier Placide, et al. "Cytotoxic Acacic Acid Glycosides From the Roots of Albizia Coriaria." Journal of Natural Products, vol. 72, no. 10, 2009, pp. 1725-30.
Noté OP, Mitaine-Offer AC, Miyamoto T, et al. Cytotoxic acacic acid glycosides from the roots of Albizia coriaria. J Nat Prod. 2009;72(10):1725-30.
Noté, O. P., Mitaine-Offer, A. C., Miyamoto, T., Paululat, T., Mirjolet, J. F., Duchamp, O., Pegnyemb, D. E., & Lacaille-Dubois, M. A. (2009). Cytotoxic acacic acid glycosides from the roots of Albizia coriaria. Journal of Natural Products, 72(10), 1725-30. https://doi.org/10.1021/np900126r
Noté OP, et al. Cytotoxic Acacic Acid Glycosides From the Roots of Albizia Coriaria. J Nat Prod. 2009;72(10):1725-30. PubMed PMID: 19778067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic acacic acid glycosides from the roots of Albizia coriaria. AU - Noté,Olivier Placide, AU - Mitaine-Offer,Anne-Claire, AU - Miyamoto,Tomofumi, AU - Paululat,Thomas, AU - Mirjolet,Jean-François, AU - Duchamp,Olivier, AU - Pegnyemb,Dieudonné Emmanuel, AU - Lacaille-Dubois,Marie-Aleth, PY - 2009/9/26/entrez PY - 2009/9/26/pubmed PY - 2009/12/16/medline SP - 1725 EP - 30 JF - Journal of natural products JO - J Nat Prod VL - 72 IS - 10 N2 - Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19778067/Cytotoxic_acacic_acid_glycosides_from_the_roots_of_Albizia_coriaria_ L2 - https://doi.org/10.1021/np900126r DB - PRIME DP - Unbound Medicine ER -