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A serosurvey of Orientia tsutsugamushi from patients with scrub typhus.
Clin Microbiol Infect. 2010 May; 16(5):447-51.CM

Abstract

Many countries where scrub typhus is endemic use their own cutoff values for antibody titres to differentiate between cured cases and current infections. To establish an antibody titre cutoff value, one needs to investigate the seroprevalence in endemic areas, and the duration of the increase in titre after complete cure. We conducted a follow-up study of anti-Orientia tsutsugamushi antibody titres using indirect immunofluorescence assays (IFA) and passive haemagglutination assays (PHA) in patients with scrub typhus. After the onset of symptoms, IgM antibody titres increased gradually over 2-3 weeks, peaked at about 4 weeks, and started to decrease rapidly between 4 and 5 weeks. At 1-year follow-up, the median IgM value was 1:10. Out of 77 patients who were tested at that time, 36 (47%) had IgM titres > or =1:20, and none had titres exceeding 1:80. Over the first 2 weeks, IgG antibody titres increased sharply, peaked at about 4 weeks and decreased rather gradually thereafter, with a median titre of 1:128 maintained up to the 18th month. At 1-year follow-up, five out of 77 patients (6.5%) had titres > or =1:1,024 and 57% had titres > or =1:128. Based on these results, a cutoff value of > or =1:160 for IgM antibody should differentiate between previous and current infections in endemic areas such as Korea and Japan, where scrub typhus occurs mainly in the autumn.

Authors+Show Affiliations

Departments of Internal Medicine and Research Center for Resistant Cells, School of Medicine, National Institute of Health, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19778303

Citation

Kim, D M., et al. "A Serosurvey of Orientia Tsutsugamushi From Patients With Scrub Typhus." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 16, no. 5, 2010, pp. 447-51.
Kim DM, Lee YM, Back JH, et al. A serosurvey of Orientia tsutsugamushi from patients with scrub typhus. Clin Microbiol Infect. 2010;16(5):447-51.
Kim, D. M., Lee, Y. M., Back, J. H., Yang, T. Y., Lee, J. H., Song, H. J., Shim, S. K., Hwang, K. J., & Park, M. Y. (2010). A serosurvey of Orientia tsutsugamushi from patients with scrub typhus. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 16(5), 447-51. https://doi.org/10.1111/j.1469-0691.2009.02865.x
Kim DM, et al. A Serosurvey of Orientia Tsutsugamushi From Patients With Scrub Typhus. Clin Microbiol Infect. 2010;16(5):447-51. PubMed PMID: 19778303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A serosurvey of Orientia tsutsugamushi from patients with scrub typhus. AU - Kim,D M, AU - Lee,Y-M, AU - Back,J-H, AU - Yang,T Y, AU - Lee,J H, AU - Song,H-J, AU - Shim,S-K, AU - Hwang,K-J, AU - Park,M-Y, Y1 - 2009/09/23/ PY - 2009/9/26/entrez PY - 2009/9/26/pubmed PY - 2010/7/16/medline SP - 447 EP - 51 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 16 IS - 5 N2 - Many countries where scrub typhus is endemic use their own cutoff values for antibody titres to differentiate between cured cases and current infections. To establish an antibody titre cutoff value, one needs to investigate the seroprevalence in endemic areas, and the duration of the increase in titre after complete cure. We conducted a follow-up study of anti-Orientia tsutsugamushi antibody titres using indirect immunofluorescence assays (IFA) and passive haemagglutination assays (PHA) in patients with scrub typhus. After the onset of symptoms, IgM antibody titres increased gradually over 2-3 weeks, peaked at about 4 weeks, and started to decrease rapidly between 4 and 5 weeks. At 1-year follow-up, the median IgM value was 1:10. Out of 77 patients who were tested at that time, 36 (47%) had IgM titres > or =1:20, and none had titres exceeding 1:80. Over the first 2 weeks, IgG antibody titres increased sharply, peaked at about 4 weeks and decreased rather gradually thereafter, with a median titre of 1:128 maintained up to the 18th month. At 1-year follow-up, five out of 77 patients (6.5%) had titres > or =1:1,024 and 57% had titres > or =1:128. Based on these results, a cutoff value of > or =1:160 for IgM antibody should differentiate between previous and current infections in endemic areas such as Korea and Japan, where scrub typhus occurs mainly in the autumn. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/19778303/A_serosurvey_of_Orientia_tsutsugamushi_from_patients_with_scrub_typhus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)63316-4 DB - PRIME DP - Unbound Medicine ER -