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Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review.

Abstract

The objective of this study was to perform a systematic review of the literature to determine whether there is an association between polycystic ovary syndrome (PCOS) and gynaecological malignancy. Medline and Embase databases (1968-2008) were searched to identify publications on the association between PCOS and gynaecological cancers including breast cancer. Studies were selected that examined the association between PCOS and all types of gynaecological malignancies. A total of 19 studies exploring the association between PCOS and breast, endometrial and ovarian cancer were identified. Of these, only eight could be included after review. The data showed variability in the definition of PCOS. A meta-analysis of the data suggests that women with PCOS are more likely to develop cancer of the endometrium (OR 2.70, 95% CI 1.00-7.29) and ovarian cancer (OR 2.52, 95% CI 1.08-5.89) but not breast cancer (OR 0.88, 95% CI 0.44-1.77). Women with PCOS appear to be three times more likely to develop endometrial cancer but are not at increased risk of breast cancer. There is insufficient evidence to implicate PCOS in the development of vaginal, vulval, cervical or ovarian cancers. The paucity of studies investigating the association between PCOS and gynaecological cancers is likely to affect the reliability of the conclusions.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Obstetrics and Gynaecology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZL, UK. brad.chittenden@nhs.net

    , ,

    Source

    Reproductive biomedicine online 19:3 2009 Sep pg 398-405

    MeSH

    Breast Neoplasms
    Disease Susceptibility
    Female
    Genital Neoplasms, Female
    Humans
    Polycystic Ovary Syndrome
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    19778486

    Citation

    Chittenden, B G., et al. "Polycystic Ovary Syndrome and the Risk of Gynaecological Cancer: a Systematic Review." Reproductive Biomedicine Online, vol. 19, no. 3, 2009, pp. 398-405.
    Chittenden BG, Fullerton G, Maheshwari A, et al. Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reprod Biomed Online. 2009;19(3):398-405.
    Chittenden, B. G., Fullerton, G., Maheshwari, A., & Bhattacharya, S. (2009). Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reproductive Biomedicine Online, 19(3), pp. 398-405.
    Chittenden BG, et al. Polycystic Ovary Syndrome and the Risk of Gynaecological Cancer: a Systematic Review. Reprod Biomed Online. 2009;19(3):398-405. PubMed PMID: 19778486.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. AU - Chittenden,B G, AU - Fullerton,G, AU - Maheshwari,A, AU - Bhattacharya,S, PY - 2009/9/26/entrez PY - 2009/9/26/pubmed PY - 2010/10/1/medline SP - 398 EP - 405 JF - Reproductive biomedicine online JO - Reprod. Biomed. Online VL - 19 IS - 3 N2 - The objective of this study was to perform a systematic review of the literature to determine whether there is an association between polycystic ovary syndrome (PCOS) and gynaecological malignancy. Medline and Embase databases (1968-2008) were searched to identify publications on the association between PCOS and gynaecological cancers including breast cancer. Studies were selected that examined the association between PCOS and all types of gynaecological malignancies. A total of 19 studies exploring the association between PCOS and breast, endometrial and ovarian cancer were identified. Of these, only eight could be included after review. The data showed variability in the definition of PCOS. A meta-analysis of the data suggests that women with PCOS are more likely to develop cancer of the endometrium (OR 2.70, 95% CI 1.00-7.29) and ovarian cancer (OR 2.52, 95% CI 1.08-5.89) but not breast cancer (OR 0.88, 95% CI 0.44-1.77). Women with PCOS appear to be three times more likely to develop endometrial cancer but are not at increased risk of breast cancer. There is insufficient evidence to implicate PCOS in the development of vaginal, vulval, cervical or ovarian cancers. The paucity of studies investigating the association between PCOS and gynaecological cancers is likely to affect the reliability of the conclusions. SN - 1472-6491 UR - https://www.unboundmedicine.com/medline/citation/19778486/Polycystic_ovary_syndrome_and_the_risk_of_gynaecological_cancer:_a_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(10)60175-7 DB - PRIME DP - Unbound Medicine ER -