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Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease.
J Neurochem. 2009 Dec; 111(5):1075-93.JN

Abstract

Parkinson's disease (PD) is one of the most common movement disorders caused by the loss of dopaminergic neuronal cells. The molecular mechanisms underlying neuronal degeneration in PD remain unknown; however, it is now clear that genetic factors contribute to the pathogenesis of this disease. Approximately, 5% of patients with clinical features of PD have clear familial etiology, which show a classical recessive or dominant Mendelian mode of inheritance. Over the decade, more than 15 loci and 11 causative genes have been identified so far and many studies shed light on their implication in not only monogenic but also sporadic form of PD. Recent studies revealed that PD-associated genes play important roles in cellular functions, such as mitochondrial functions, ubiquitin-proteasomal system, autophagy-lysosomal pathway and membrane trafficking. Furthermore, the proteins encoded by PD-associated genes can interact with each other and such gene products may share a common pathway that leads to nigral degeneration. However, their precise roles in the disease and their normal functions remain poorly understood. In this study, we review recent progress in knowledge about the genes associated with familial PD.

Authors+Show Affiliations

Department of Neurology, Juntendo University, School of Medicine, Hongo Bunkyo Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19780902

Citation

Hatano, Taku, et al. "Pathogenesis of Familial Parkinson's Disease: New Insights Based On Monogenic Forms of Parkinson's Disease." Journal of Neurochemistry, vol. 111, no. 5, 2009, pp. 1075-93.
Hatano T, Kubo S, Sato S, et al. Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease. J Neurochem. 2009;111(5):1075-93.
Hatano, T., Kubo, S., Sato, S., & Hattori, N. (2009). Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease. Journal of Neurochemistry, 111(5), 1075-93. https://doi.org/10.1111/j.1471-4159.2009.06403.x
Hatano T, et al. Pathogenesis of Familial Parkinson's Disease: New Insights Based On Monogenic Forms of Parkinson's Disease. J Neurochem. 2009;111(5):1075-93. PubMed PMID: 19780902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease. AU - Hatano,Taku, AU - Kubo,Shin-ichiro, AU - Sato,Shigeto, AU - Hattori,Nobutaka, Y1 - 2009/09/24/ PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2009/12/16/medline SP - 1075 EP - 93 JF - Journal of neurochemistry JO - J Neurochem VL - 111 IS - 5 N2 - Parkinson's disease (PD) is one of the most common movement disorders caused by the loss of dopaminergic neuronal cells. The molecular mechanisms underlying neuronal degeneration in PD remain unknown; however, it is now clear that genetic factors contribute to the pathogenesis of this disease. Approximately, 5% of patients with clinical features of PD have clear familial etiology, which show a classical recessive or dominant Mendelian mode of inheritance. Over the decade, more than 15 loci and 11 causative genes have been identified so far and many studies shed light on their implication in not only monogenic but also sporadic form of PD. Recent studies revealed that PD-associated genes play important roles in cellular functions, such as mitochondrial functions, ubiquitin-proteasomal system, autophagy-lysosomal pathway and membrane trafficking. Furthermore, the proteins encoded by PD-associated genes can interact with each other and such gene products may share a common pathway that leads to nigral degeneration. However, their precise roles in the disease and their normal functions remain poorly understood. In this study, we review recent progress in knowledge about the genes associated with familial PD. SN - 1471-4159 UR - https://www.unboundmedicine.com/medline/citation/19780902/Pathogenesis_of_familial_Parkinson's_disease:_new_insights_based_on_monogenic_forms_of_Parkinson's_disease_ L2 - https://doi.org/10.1111/j.1471-4159.2009.06403.x DB - PRIME DP - Unbound Medicine ER -