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Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake.
Br J Nutr. 2010 Feb; 103(4):561-8.BJ

Abstract

Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca:P ratio is therefore difficult to achieve. Our objective was to investigate how habitual dietary Ca:P ratio affects serum PTH (S-PTH) concentration and other Ca metabolism markers in a population with generally adequate Ca intake. In this cross-sectional analysis of 147 healthy women aged 31-43 years, fasting blood samples and three separate 24-h urinary samples were collected. Participants kept a 4-d food record and were divided into quartiles according to their dietary Ca:P ratios. The 1st quartile with Ca:P molar ratio < or = 0.50 differed significantly from the 2nd (Ca:P molar ratio 0.51-0.57), 3rd (Ca:P molar ratio 0.58-0.64) and 4th (Ca:P molar ratio > or = 0.65) quartiles by interfering with Ca metabolism. In the 1st quartile, mean S-PTH concentration (P = 0.021) and mean urinary Ca (U-Ca) excretion were higher (P = 0.051) than in all other quartiles. These findings suggest that in habitual diets low Ca:P ratios may interfere with homoeostasis of Ca metabolism and increase bone resorption, as indicated by higher S-PTH and U-Ca levels. Because low habitual dietary Ca:P ratios are common in Western diets, more attention should be focused on decreasing excessively high dietary P intake and increasing Ca intake to the recommended level.

Authors+Show Affiliations

Calcium Research Unit, Department of Applied Chemistry and Microbiology, PO Box 66, FI-00014 University of Helsinki, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19781123

Citation

Kemi, Virpi E., et al. "Low Calcium:phosphorus Ratio in Habitual Diets Affects Serum Parathyroid Hormone Concentration and Calcium Metabolism in Healthy Women With Adequate Calcium Intake." The British Journal of Nutrition, vol. 103, no. 4, 2010, pp. 561-8.
Kemi VE, Kärkkäinen MU, Rita HJ, et al. Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake. Br J Nutr. 2010;103(4):561-8.
Kemi, V. E., Kärkkäinen, M. U., Rita, H. J., Laaksonen, M. M., Outila, T. A., & Lamberg-Allardt, C. J. (2010). Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake. The British Journal of Nutrition, 103(4), 561-8. https://doi.org/10.1017/S0007114509992121
Kemi VE, et al. Low Calcium:phosphorus Ratio in Habitual Diets Affects Serum Parathyroid Hormone Concentration and Calcium Metabolism in Healthy Women With Adequate Calcium Intake. Br J Nutr. 2010;103(4):561-8. PubMed PMID: 19781123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake. AU - Kemi,Virpi E, AU - Kärkkäinen,Merja U M, AU - Rita,Hannu J, AU - Laaksonen,Marika M L, AU - Outila,Terhi A, AU - Lamberg-Allardt,Christel J E, Y1 - 2009/09/28/ PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/3/5/medline SP - 561 EP - 8 JF - The British journal of nutrition JO - Br J Nutr VL - 103 IS - 4 N2 - Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca:P ratio is therefore difficult to achieve. Our objective was to investigate how habitual dietary Ca:P ratio affects serum PTH (S-PTH) concentration and other Ca metabolism markers in a population with generally adequate Ca intake. In this cross-sectional analysis of 147 healthy women aged 31-43 years, fasting blood samples and three separate 24-h urinary samples were collected. Participants kept a 4-d food record and were divided into quartiles according to their dietary Ca:P ratios. The 1st quartile with Ca:P molar ratio < or = 0.50 differed significantly from the 2nd (Ca:P molar ratio 0.51-0.57), 3rd (Ca:P molar ratio 0.58-0.64) and 4th (Ca:P molar ratio > or = 0.65) quartiles by interfering with Ca metabolism. In the 1st quartile, mean S-PTH concentration (P = 0.021) and mean urinary Ca (U-Ca) excretion were higher (P = 0.051) than in all other quartiles. These findings suggest that in habitual diets low Ca:P ratios may interfere with homoeostasis of Ca metabolism and increase bone resorption, as indicated by higher S-PTH and U-Ca levels. Because low habitual dietary Ca:P ratios are common in Western diets, more attention should be focused on decreasing excessively high dietary P intake and increasing Ca intake to the recommended level. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19781123/Low_calcium:phosphorus_ratio_in_habitual_diets_affects_serum_parathyroid_hormone_concentration_and_calcium_metabolism_in_healthy_women_with_adequate_calcium_intake_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509992121/type/journal_article DB - PRIME DP - Unbound Medicine ER -