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Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.
Neurobiol Dis 2010; 37(2):294-306ND

Abstract

Amyloid beta peptides and microtubule-associated protein Tau are misfolded and form aggregates in brains of Alzheimer's disease patients. To examine their specific roles in the pathogenesis of Alzheimer's disease and their relevance in neurodegenerative processes, we have created TauPS2APP triple transgenic mice that express human mutated Amyloid Precursor Protein, presenilin 2 and Tau. We present a cross-sectional analysis of these mice at 4, 8, 12 and 16 months of age. By comparing with single transgenic Tau mice, we demonstrate that accumulation of Abeta in TauPS2APP triple transgenic mice impacts on Tau pathology by increasing the phosphorylation of Tau at serine 422, as determined by a novel immunodetection method that is able to reliably measure phospho-Tau species in transgenic mouse brains. The TauPS2APP triple transgenic mouse model will be very useful for studying the effect of new therapeutic paradigms on amyloid deposition and downstream neurofibrillary tangle development.

Authors+Show Affiliations

F. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19781645

Citation

Grueninger, Fiona, et al. "Phosphorylation of Tau at S422 Is Enhanced By Abeta in TauPS2APP Triple Transgenic Mice." Neurobiology of Disease, vol. 37, no. 2, 2010, pp. 294-306.
Grueninger F, Bohrmann B, Czech C, et al. Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. Neurobiol Dis. 2010;37(2):294-306.
Grueninger, F., Bohrmann, B., Czech, C., Ballard, T. M., Frey, J. R., Weidensteiner, C., ... Ozmen, L. (2010). Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. Neurobiology of Disease, 37(2), pp. 294-306. doi:10.1016/j.nbd.2009.09.004.
Grueninger F, et al. Phosphorylation of Tau at S422 Is Enhanced By Abeta in TauPS2APP Triple Transgenic Mice. Neurobiol Dis. 2010;37(2):294-306. PubMed PMID: 19781645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. AU - Grueninger,Fiona, AU - Bohrmann,Bernd, AU - Czech,Christian, AU - Ballard,Theresa Maria, AU - Frey,Johann R, AU - Weidensteiner,Claudia, AU - von Kienlin,Markus, AU - Ozmen,Laurence, Y1 - 2009/09/23/ PY - 2009/03/24/received PY - 2009/09/01/revised PY - 2009/09/10/accepted PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/6/16/medline SP - 294 EP - 306 JF - Neurobiology of disease JO - Neurobiol. Dis. VL - 37 IS - 2 N2 - Amyloid beta peptides and microtubule-associated protein Tau are misfolded and form aggregates in brains of Alzheimer's disease patients. To examine their specific roles in the pathogenesis of Alzheimer's disease and their relevance in neurodegenerative processes, we have created TauPS2APP triple transgenic mice that express human mutated Amyloid Precursor Protein, presenilin 2 and Tau. We present a cross-sectional analysis of these mice at 4, 8, 12 and 16 months of age. By comparing with single transgenic Tau mice, we demonstrate that accumulation of Abeta in TauPS2APP triple transgenic mice impacts on Tau pathology by increasing the phosphorylation of Tau at serine 422, as determined by a novel immunodetection method that is able to reliably measure phospho-Tau species in transgenic mouse brains. The TauPS2APP triple transgenic mouse model will be very useful for studying the effect of new therapeutic paradigms on amyloid deposition and downstream neurofibrillary tangle development. SN - 1095-953X UR - https://www.unboundmedicine.com/medline/citation/19781645/Phosphorylation_of_Tau_at_S422_is_enhanced_by_Abeta_in_TauPS2APP_triple_transgenic_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(09)00245-9 DB - PRIME DP - Unbound Medicine ER -