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Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat model.
Exp Eye Res. 2010 Jan; 90(1):97-103.EE

Abstract

Agmatine, a primary polyamine and potential neuromodulator, exhibits a high affinity to the alpha2-adrenergic receptor as well as imidazoline receptors. As alpha2-adrenergic receptor agonists display positive ocular hypotensive effects, we assessed whether agmatine effectively lowers intraocular pressure (IOP) using a chronic ocular hypertensive rat model. We raised IOP in unilateral eyes of Sprague-Dawley rats by cauterizing three episcleral veins per eye. Four weeks later, we topically administered 10(-3) M agmatine solution 4 times a day for 6 consecutive weeks. After confirming the recovery of IOP to pretreatment level at 13 weeks after cauterization, the retinal ganglion cells (RGCs) were retrogradely labeled and counted. Eyes subjected to episcleral vein cauterization (EVC) demonstrated significant increases in IOP (48.39% increase over baseline IOP), and the elevated IOP was well maintained until 12 weeks. Topically administered agmatine powerfully lowered IOP to 30.29% of its pretreatment level, and the associated washout period was about two weeks. EVC was associated with a 55.44% loss of RGCs in the control group, but agmatine appeared to attenuate this RGC loss to 18.65%. Overall, topically administered agmatine appeared to effectively lower IOP and rescue RGCs in a chronic ocular hypertensive rat model. Although the mechanism underlying these effects is not yet established, it is possible that agmatine offers a powerful new ocular hypotensive agent for eyes with chronic ocular hypertension and/or glaucoma.

Authors+Show Affiliations

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul 135-720, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19782071

Citation

Hong, Samin, et al. "Ocular Hypotensive Effects of Topically Administered Agmatine in a Chronic Ocular Hypertensive Rat Model." Experimental Eye Research, vol. 90, no. 1, 2010, pp. 97-103.
Hong S, Kim CY, Lee WS, et al. Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat model. Exp Eye Res. 2010;90(1):97-103.
Hong, S., Kim, C. Y., Lee, W. S., Shim, J., Yeom, H. Y., & Seong, G. J. (2010). Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat model. Experimental Eye Research, 90(1), 97-103. https://doi.org/10.1016/j.exer.2009.09.016
Hong S, et al. Ocular Hypotensive Effects of Topically Administered Agmatine in a Chronic Ocular Hypertensive Rat Model. Exp Eye Res. 2010;90(1):97-103. PubMed PMID: 19782071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat model. AU - Hong,Samin, AU - Kim,Chan Yun, AU - Lee,Won Seok, AU - Shim,Jongwoo, AU - Yeom,Ho Yeop, AU - Seong,Gong Je, Y1 - 2009/09/24/ PY - 2009/04/19/received PY - 2009/09/09/revised PY - 2009/09/18/accepted PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/1/16/medline SP - 97 EP - 103 JF - Experimental eye research JO - Exp Eye Res VL - 90 IS - 1 N2 - Agmatine, a primary polyamine and potential neuromodulator, exhibits a high affinity to the alpha2-adrenergic receptor as well as imidazoline receptors. As alpha2-adrenergic receptor agonists display positive ocular hypotensive effects, we assessed whether agmatine effectively lowers intraocular pressure (IOP) using a chronic ocular hypertensive rat model. We raised IOP in unilateral eyes of Sprague-Dawley rats by cauterizing three episcleral veins per eye. Four weeks later, we topically administered 10(-3) M agmatine solution 4 times a day for 6 consecutive weeks. After confirming the recovery of IOP to pretreatment level at 13 weeks after cauterization, the retinal ganglion cells (RGCs) were retrogradely labeled and counted. Eyes subjected to episcleral vein cauterization (EVC) demonstrated significant increases in IOP (48.39% increase over baseline IOP), and the elevated IOP was well maintained until 12 weeks. Topically administered agmatine powerfully lowered IOP to 30.29% of its pretreatment level, and the associated washout period was about two weeks. EVC was associated with a 55.44% loss of RGCs in the control group, but agmatine appeared to attenuate this RGC loss to 18.65%. Overall, topically administered agmatine appeared to effectively lower IOP and rescue RGCs in a chronic ocular hypertensive rat model. Although the mechanism underlying these effects is not yet established, it is possible that agmatine offers a powerful new ocular hypotensive agent for eyes with chronic ocular hypertension and/or glaucoma. SN - 1096-0007 UR - https://www.unboundmedicine.com/medline/citation/19782071/Ocular_hypotensive_effects_of_topically_administered_agmatine_in_a_chronic_ocular_hypertensive_rat_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4835(09)00284-X DB - PRIME DP - Unbound Medicine ER -