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GSK3: a possible link between beta amyloid peptide and tau protein.
Exp Neurol. 2010 Jun; 223(2):322-5.EN

Abstract

Tau is a neuronal microtubule-associated phosphoprotein that is highly phosphorylated by glycogen synthase kinase 3 (GSK3). Tau phosphorylation by GSK3 regulates tau binding to microtubules, tau degradation and tau aggregation. Tau phosphorylation is important in Alzheimer disease pathology and in other tauopathies. In Alzheimer disease, it has been proposed that the peptide beta amyloid promotes GSK3 activation, resulting in tau phosphorylation. In this work, we review the links between beta amyloid peptide, tau protein and GSK3 that occur in familial Alzheimer disease. We also discuss the possible links between GSK3 and sporadic Alzheimer disease. Finally, we include a brief review of the pathology of animal models overexpressing GSK3.

Authors+Show Affiliations

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/Nicolás Cabrera, 1 Campus Cantoblanco, Universidad Autónoma de Madrid, 28049 Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19782073

Citation

Hernández, Félix, et al. "GSK3: a Possible Link Between Beta Amyloid Peptide and Tau Protein." Experimental Neurology, vol. 223, no. 2, 2010, pp. 322-5.
Hernández F, Gómez de Barreda E, Fuster-Matanzo A, et al. GSK3: a possible link between beta amyloid peptide and tau protein. Exp Neurol. 2010;223(2):322-5.
Hernández, F., Gómez de Barreda, E., Fuster-Matanzo, A., Lucas, J. J., & Avila, J. (2010). GSK3: a possible link between beta amyloid peptide and tau protein. Experimental Neurology, 223(2), 322-5. https://doi.org/10.1016/j.expneurol.2009.09.011
Hernández F, et al. GSK3: a Possible Link Between Beta Amyloid Peptide and Tau Protein. Exp Neurol. 2010;223(2):322-5. PubMed PMID: 19782073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GSK3: a possible link between beta amyloid peptide and tau protein. AU - Hernández,Félix, AU - Gómez de Barreda,Elena, AU - Fuster-Matanzo,Almudena, AU - Lucas,José J, AU - Avila,Jesús, Y1 - 2009/09/24/ PY - 2009/03/17/received PY - 2009/09/04/revised PY - 2009/09/17/accepted PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/7/2/medline SP - 322 EP - 5 JF - Experimental neurology JO - Exp Neurol VL - 223 IS - 2 N2 - Tau is a neuronal microtubule-associated phosphoprotein that is highly phosphorylated by glycogen synthase kinase 3 (GSK3). Tau phosphorylation by GSK3 regulates tau binding to microtubules, tau degradation and tau aggregation. Tau phosphorylation is important in Alzheimer disease pathology and in other tauopathies. In Alzheimer disease, it has been proposed that the peptide beta amyloid promotes GSK3 activation, resulting in tau phosphorylation. In this work, we review the links between beta amyloid peptide, tau protein and GSK3 that occur in familial Alzheimer disease. We also discuss the possible links between GSK3 and sporadic Alzheimer disease. Finally, we include a brief review of the pathology of animal models overexpressing GSK3. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/19782073/GSK3:_a_possible_link_between_beta_amyloid_peptide_and_tau_protein_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(09)00385-9 DB - PRIME DP - Unbound Medicine ER -