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Intermittent prenatal MDMA exposure alters physiological but not mood related parameters in adult rat offspring.
Behav Brain Res 2010; 206(2):299-309BB

Abstract

The recreational party drug "ecstasy" (3,4-methylenedioxymethamphetamine MDMA) is particularly popular among young adults who are in the childbearing age and thus there is a substantial risk of prenatal MDMA exposure. We applied an intermittent treatment protocol with an early first injection on pregnant Wistar rats (15 mg/kg MDMA s.c. on the E4, E11 and E18 days of gestation) to examine the potential physiological, endocrine and behavioral effects on adult male and female offspring. Prenatal MDMA-treatment provoked reduced body weight of offspring from the birth as far as the adulthood. Adult MDMA-offspring had a reduced blood-glucose concentration and hematocrit, altered relative spleen and thymus weight, had lower performance on wire suspension test and on the first trial of rotarod test. In contrast, no alteration in the locomotor activity was found. Anxiety and depression related behavioral parameters in elevated plus maze, sucrose preference or forced swimming tests were normal. MDMA-offspring had elevated concentration of the ACTH-precursor proopiomelanocortin and male MDMA-offspring exhibited elevated blood corticosterone concentration. No significant alteration was detected in the serotonergic marker tryptophan-hydroxylase and the catcholaminergic marker tyrosine-hydroxylase immunoreactive fiber densities in MDMA-offspring. The mothers exhibited reduced densities of serotonergic but not catecholaminergic fibers after the MDMA treatment. Our findings suggest that an intermittent prenatal MDMA exposure with an early first injection and a relatively low cumulative dose provokes mild but significant alterations in physical-physiological parameters and reduces motor skill learning in adulthood. In contrast, these adult offspring do not produce anxiety or depression like behavior.

Authors+Show Affiliations

Department of Pharmacodynamics, Semmelweis University, H-1085, Budapest, Nagyvárad tér 4, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19782105

Citation

Adori, Csaba, et al. "Intermittent Prenatal MDMA Exposure Alters Physiological but Not Mood Related Parameters in Adult Rat Offspring." Behavioural Brain Research, vol. 206, no. 2, 2010, pp. 299-309.
Adori C, Zelena D, Tímár J, et al. Intermittent prenatal MDMA exposure alters physiological but not mood related parameters in adult rat offspring. Behav Brain Res. 2010;206(2):299-309.
Adori, C., Zelena, D., Tímár, J., Gyarmati, Z., Domokos, A., Sobor, M., ... Bagdy, G. (2010). Intermittent prenatal MDMA exposure alters physiological but not mood related parameters in adult rat offspring. Behavioural Brain Research, 206(2), pp. 299-309. doi:10.1016/j.bbr.2009.09.031.
Adori C, et al. Intermittent Prenatal MDMA Exposure Alters Physiological but Not Mood Related Parameters in Adult Rat Offspring. Behav Brain Res. 2010 Jan 20;206(2):299-309. PubMed PMID: 19782105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intermittent prenatal MDMA exposure alters physiological but not mood related parameters in adult rat offspring. AU - Adori,Csaba, AU - Zelena,Dóra, AU - Tímár,Júlia, AU - Gyarmati,Zsuzsa, AU - Domokos,Agnes, AU - Sobor,Melinda, AU - Fürst,Zsuzsanna, AU - Makara,Gábor, AU - Bagdy,György, Y1 - 2009/09/24/ PY - 2009/07/03/received PY - 2009/09/18/revised PY - 2009/09/21/accepted PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/1/7/medline SP - 299 EP - 309 JF - Behavioural brain research JO - Behav. Brain Res. VL - 206 IS - 2 N2 - The recreational party drug "ecstasy" (3,4-methylenedioxymethamphetamine MDMA) is particularly popular among young adults who are in the childbearing age and thus there is a substantial risk of prenatal MDMA exposure. We applied an intermittent treatment protocol with an early first injection on pregnant Wistar rats (15 mg/kg MDMA s.c. on the E4, E11 and E18 days of gestation) to examine the potential physiological, endocrine and behavioral effects on adult male and female offspring. Prenatal MDMA-treatment provoked reduced body weight of offspring from the birth as far as the adulthood. Adult MDMA-offspring had a reduced blood-glucose concentration and hematocrit, altered relative spleen and thymus weight, had lower performance on wire suspension test and on the first trial of rotarod test. In contrast, no alteration in the locomotor activity was found. Anxiety and depression related behavioral parameters in elevated plus maze, sucrose preference or forced swimming tests were normal. MDMA-offspring had elevated concentration of the ACTH-precursor proopiomelanocortin and male MDMA-offspring exhibited elevated blood corticosterone concentration. No significant alteration was detected in the serotonergic marker tryptophan-hydroxylase and the catcholaminergic marker tyrosine-hydroxylase immunoreactive fiber densities in MDMA-offspring. The mothers exhibited reduced densities of serotonergic but not catecholaminergic fibers after the MDMA treatment. Our findings suggest that an intermittent prenatal MDMA exposure with an early first injection and a relatively low cumulative dose provokes mild but significant alterations in physical-physiological parameters and reduces motor skill learning in adulthood. In contrast, these adult offspring do not produce anxiety or depression like behavior. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19782105/Intermittent_prenatal_MDMA_exposure_alters_physiological_but_not_mood_related_parameters_in_adult_rat_offspring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00562-2 DB - PRIME DP - Unbound Medicine ER -