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Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells.
Cancer Lett. 2010 Apr 01; 290(1):123-8.CL

Abstract

The secondary bile acid lithocholic acid (LCA) induced expression of urokinase-type plasminogen activator receptor (uPAR) and enhanced cell invasiveness in colon cancer cells. A dominant negative mutant or a specific inhibitor of MEK-1 suppressed LCA-induced uPAR expression. Deletions and site-directed mutagenesis revealed that the AP-1 site was required for LCA-induced uPAR transcription. LCA-mediated enhanced cell invasiveness was partially abrogated by uPAR neutralizing antibody and inhibitors of both Erk-1/2 and AP-1. These results suggest that LCA induces uPAR expression via Erk-1/2 and AP-1 pathway and, in turn, stimulate invasiveness of human colon cancer cells.

Authors+Show Affiliations

Center for Biomedical Human Resources at Chonnam National University, Chonnam National University Medical School, Gwangju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19782465

Citation

Baek, Min Kyung, et al. "Lithocholic Acid Upregulates uPAR and Cell Invasiveness Via MAPK and AP-1 Signaling in Colon Cancer Cells." Cancer Letters, vol. 290, no. 1, 2010, pp. 123-8.
Baek MK, Park JS, Park JH, et al. Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells. Cancer Lett. 2010;290(1):123-8.
Baek, M. K., Park, J. S., Park, J. H., Kim, M. H., Kim, H. D., Bae, W. K., Chung, I. J., Shin, B. A., & Jung, Y. D. (2010). Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells. Cancer Letters, 290(1), 123-8. https://doi.org/10.1016/j.canlet.2009.08.030
Baek MK, et al. Lithocholic Acid Upregulates uPAR and Cell Invasiveness Via MAPK and AP-1 Signaling in Colon Cancer Cells. Cancer Lett. 2010 Apr 1;290(1):123-8. PubMed PMID: 19782465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells. AU - Baek,Min Kyung, AU - Park,Jung Sun, AU - Park,Ji Hye, AU - Kim,Mi Ha, AU - Kim,Ho Dong, AU - Bae,Woo Kyun, AU - Chung,Ik Joo, AU - Shin,Boo Ahn, AU - Jung,Young Do, Y1 - 2009/09/25/ PY - 2009/06/23/received PY - 2009/08/26/revised PY - 2009/08/31/accepted PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/4/8/medline SP - 123 EP - 8 JF - Cancer letters JO - Cancer Lett VL - 290 IS - 1 N2 - The secondary bile acid lithocholic acid (LCA) induced expression of urokinase-type plasminogen activator receptor (uPAR) and enhanced cell invasiveness in colon cancer cells. A dominant negative mutant or a specific inhibitor of MEK-1 suppressed LCA-induced uPAR expression. Deletions and site-directed mutagenesis revealed that the AP-1 site was required for LCA-induced uPAR transcription. LCA-mediated enhanced cell invasiveness was partially abrogated by uPAR neutralizing antibody and inhibitors of both Erk-1/2 and AP-1. These results suggest that LCA induces uPAR expression via Erk-1/2 and AP-1 pathway and, in turn, stimulate invasiveness of human colon cancer cells. SN - 1872-7980 UR - https://www.unboundmedicine.com/medline/citation/19782465/Lithocholic_acid_upregulates_uPAR_and_cell_invasiveness_via_MAPK_and_AP_1_signaling_in_colon_cancer_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(09)00570-9 DB - PRIME DP - Unbound Medicine ER -