TY - JOUR T1 - Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells. AU - Baek,Min Kyung, AU - Park,Jung Sun, AU - Park,Ji Hye, AU - Kim,Mi Ha, AU - Kim,Ho Dong, AU - Bae,Woo Kyun, AU - Chung,Ik Joo, AU - Shin,Boo Ahn, AU - Jung,Young Do, Y1 - 2009/09/25/ PY - 2009/06/23/received PY - 2009/08/26/revised PY - 2009/08/31/accepted PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/4/8/medline SP - 123 EP - 8 JF - Cancer letters JO - Cancer Lett VL - 290 IS - 1 N2 - The secondary bile acid lithocholic acid (LCA) induced expression of urokinase-type plasminogen activator receptor (uPAR) and enhanced cell invasiveness in colon cancer cells. A dominant negative mutant or a specific inhibitor of MEK-1 suppressed LCA-induced uPAR expression. Deletions and site-directed mutagenesis revealed that the AP-1 site was required for LCA-induced uPAR transcription. LCA-mediated enhanced cell invasiveness was partially abrogated by uPAR neutralizing antibody and inhibitors of both Erk-1/2 and AP-1. These results suggest that LCA induces uPAR expression via Erk-1/2 and AP-1 pathway and, in turn, stimulate invasiveness of human colon cancer cells. SN - 1872-7980 UR - https://www.unboundmedicine.com/medline/citation/19782465/Lithocholic_acid_upregulates_uPAR_and_cell_invasiveness_via_MAPK_and_AP_1_signaling_in_colon_cancer_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(09)00570-9 DB - PRIME DP - Unbound Medicine ER -