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Daily marijuana users with past alcohol problems increase alcohol consumption during marijuana abstinence.

Abstract

Drug abuse treatment programs typically recommend complete abstinence because of a fear that clients who stop use of one drug will substitute another. A within-subjects study investigated whether consumption of alcohol and other substances changes during marijuana abstinence. Twenty-eight daily marijuana users who were not trying to stop or reduce their marijuana consumption completed an 8-day baseline period in which they used marijuana and other drugs as usual, a 13-day marijuana abstinence period, and a 7-day return-to-baseline period. Participants provided self-report of substance use daily and submitted urine samples twice weekly to verify marijuana abstinence. A diagnosis of past alcohol abuse or dependence significantly moderated the alcohol increase from baseline to marijuana abstinence (p<0.01), such that individuals with this diagnosis significantly increased alcohol use (52% increase) but those without this history did not (3% increase). Increases in marijuana withdrawal discomfort scores and alcohol craving scores from baseline to marijuana abstinence significantly and positively correlated with increases in alcohol use. Increases in cigarettes, caffeine, and non-marijuana illicit drugs did not occur. This study provides empirical validation of drug substitution in a subgroup of daily marijuana users, but results need to be replicated in individuals who seek treatment for marijuana problems.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Yale University School of Medicine, The APT Foundation, One Long Wharf, New Haven, CT 06511, USA. erica.peters@yale.edu

    Source

    Drug and alcohol dependence 106:2-3 2010 Jan 15 pg 111-8

    MeSH

    Adolescent
    Adult
    Aggression
    Alcohol Drinking
    Alcoholism
    Anger
    Depression
    Diagnostic and Statistical Manual of Mental Disorders
    Dronabinol
    Eating Disorders
    Educational Status
    Employment
    Female
    Humans
    Male
    Marijuana Abuse
    Marital Status
    Patient Selection
    Sleep Disorders
    Substance Withdrawal Syndrome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19783385

    Citation

    TY - JOUR T1 - Daily marijuana users with past alcohol problems increase alcohol consumption during marijuana abstinence. AU - Peters,Erica N, AU - Hughes,John R, Y1 - 2009/09/23/ PY - 2009/6/1/received PY - 2009/7/29/revised PY - 2009/7/30/accepted PY - 2009/9/23/aheadofprint PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2010/4/24/medline SP - 111 EP - 8 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 106 IS - 2-3 N2 - Drug abuse treatment programs typically recommend complete abstinence because of a fear that clients who stop use of one drug will substitute another. A within-subjects study investigated whether consumption of alcohol and other substances changes during marijuana abstinence. Twenty-eight daily marijuana users who were not trying to stop or reduce their marijuana consumption completed an 8-day baseline period in which they used marijuana and other drugs as usual, a 13-day marijuana abstinence period, and a 7-day return-to-baseline period. Participants provided self-report of substance use daily and submitted urine samples twice weekly to verify marijuana abstinence. A diagnosis of past alcohol abuse or dependence significantly moderated the alcohol increase from baseline to marijuana abstinence (p<0.01), such that individuals with this diagnosis significantly increased alcohol use (52% increase) but those without this history did not (3% increase). Increases in marijuana withdrawal discomfort scores and alcohol craving scores from baseline to marijuana abstinence significantly and positively correlated with increases in alcohol use. Increases in cigarettes, caffeine, and non-marijuana illicit drugs did not occur. This study provides empirical validation of drug substitution in a subgroup of daily marijuana users, but results need to be replicated in individuals who seek treatment for marijuana problems. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/19783385/full_citation/Daily_marijuana_users_with_past_alcohol_problems_increase_alcohol_consumption_during_marijuana_abstinence_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0376-8716(09)00325-1 ER -