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Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats.
Pak J Pharm Sci. 2009 Oct; 22(4):391-4.PJ

Abstract

Hepatoprotective activity of ethanolic extract of flowers of Vitex trifolia (Verbenaceae) was studied against CCl4 induced hepatic injury in albino rats. The plant extract (EVT) at the dose of 200 mg/kg, p.o. showed a remarkable hepatoprotective activity. CCl4 induced a significant rise in serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Treatment of rats with EVT significantly (P<0.001) altered serum biomarker enzyme levels to near normal against CCl4 treated rats. The activity of the extract was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Histopathological observations also revealed that treatment with EVT protected the animals from CCl4 induced liver damage. The results indicate that the flowers of V. trifolia possess hepatoprotective activity on CCl4 induced hepatic injury in rats.

Authors+Show Affiliations

Anandan R
Vinayaka Mission's College of Pharmacy, Salem-636 008, Tamilnadu, India.
Jayakar B
No affiliation info available
Karar B
No affiliation info available
Babuji S
No affiliation info available
Manavalan R
No affiliation info available
Kumar RS
No affiliation info available

MeSH

AnimalsCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryEthanolFemaleFlowersIndiaLiverLiver Function TestsMaleMiceOrgan SizePlant ExtractsRatsRats, WistarSolventsVitex

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19783517

Citation

Anandan, Ramasamy, et al. "Effect of Ethanol Extract of Flowers of Vitex Trifolia Linn. On CCL4 Induced Hepatic Injury in Rats." Pakistan Journal of Pharmaceutical Sciences, vol. 22, no. 4, 2009, pp. 391-4.
Anandan R, Jayakar B, Karar B, et al. Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats. Pak J Pharm Sci. 2009;22(4):391-4.
Anandan, R., Jayakar, B., Karar, B., Babuji, S., Manavalan, R., & Kumar, R. S. (2009). Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats. Pakistan Journal of Pharmaceutical Sciences, 22(4), 391-4.
Anandan R, et al. Effect of Ethanol Extract of Flowers of Vitex Trifolia Linn. On CCL4 Induced Hepatic Injury in Rats. Pak J Pharm Sci. 2009;22(4):391-4. PubMed PMID: 19783517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats. AU - Anandan,Ramasamy, AU - Jayakar,Balasundaram, AU - Karar,Biusan, AU - Babuji,Seevalen, AU - Manavalan,Rajappan, AU - Kumar,Raju Senthil, PY - 2009/9/29/entrez PY - 2009/9/29/pubmed PY - 2009/12/16/medline SP - 391 EP - 4 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 22 IS - 4 N2 - Hepatoprotective activity of ethanolic extract of flowers of Vitex trifolia (Verbenaceae) was studied against CCl4 induced hepatic injury in albino rats. The plant extract (EVT) at the dose of 200 mg/kg, p.o. showed a remarkable hepatoprotective activity. CCl4 induced a significant rise in serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). Treatment of rats with EVT significantly (P<0.001) altered serum biomarker enzyme levels to near normal against CCl4 treated rats. The activity of the extract was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Histopathological observations also revealed that treatment with EVT protected the animals from CCl4 induced liver damage. The results indicate that the flowers of V. trifolia possess hepatoprotective activity on CCl4 induced hepatic injury in rats. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/19783517/Effect_of_ethanol_extract_of_flowers_of_Vitex_trifolia_Linn__on_CCL4_induced_hepatic_injury_in_rats_ L2 - https://medlineplus.gov/drugreactions.html DB - PRIME DP - Unbound Medicine ER -