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Paralysis and pernicious anemia in a young woman.
J La State Med Soc. 2009 Jul-Aug; 161(4):228-32.JL

Abstract

Vitamin B12 is important for normal nervous system functioning, and deficiencies are associated with various neurological abnormalities. We present a case of an 18-year-old woman who presented with significant neurological sequelae, but only mild hematologic abnormalities and normal vitamin B12 levels. She was found to have a moderately increased mean corpuscular volume, a markedly elevated homocysteine level, and a greatly increased methylmalonic acid level. In symptomatic patients it is important for physicians to maintain a high index of suspicion for B12 deficiency despite normal serum levels. The measurement of MMA and homocysteine levels provides much more sensitive tests, but even these tests do not completely rule out a deficiency. Although, the traditional treatment for vitamin B12 deficiency has been intramuscular cobalamin injections, recent studies have shown that oral cobalamin may be as efficacious.

Authors+Show Affiliations

Internal Medicine Residency Program, Ochsner Clinic Foundation, New Orleans, LA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19785315

Citation

Matrana, Marc R., et al. "Paralysis and Pernicious Anemia in a Young Woman." The Journal of the Louisiana State Medical Society : Official Organ of the Louisiana State Medical Society, vol. 161, no. 4, 2009, pp. 228-32.
Matrana MR, Gauthier C, Lafaye KM. Paralysis and pernicious anemia in a young woman. J La State Med Soc. 2009;161(4):228-32.
Matrana, M. R., Gauthier, C., & Lafaye, K. M. (2009). Paralysis and pernicious anemia in a young woman. The Journal of the Louisiana State Medical Society : Official Organ of the Louisiana State Medical Society, 161(4), 228-32.
Matrana MR, Gauthier C, Lafaye KM. Paralysis and Pernicious Anemia in a Young Woman. J La State Med Soc. 2009 Jul-Aug;161(4):228-32. PubMed PMID: 19785315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paralysis and pernicious anemia in a young woman. AU - Matrana,Marc R, AU - Gauthier,Carl, AU - Lafaye,Kristina M, PY - 2009/9/30/entrez PY - 2009/9/30/pubmed PY - 2009/10/17/medline SP - 228 EP - 32 JF - The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society JO - J La State Med Soc VL - 161 IS - 4 N2 - Vitamin B12 is important for normal nervous system functioning, and deficiencies are associated with various neurological abnormalities. We present a case of an 18-year-old woman who presented with significant neurological sequelae, but only mild hematologic abnormalities and normal vitamin B12 levels. She was found to have a moderately increased mean corpuscular volume, a markedly elevated homocysteine level, and a greatly increased methylmalonic acid level. In symptomatic patients it is important for physicians to maintain a high index of suspicion for B12 deficiency despite normal serum levels. The measurement of MMA and homocysteine levels provides much more sensitive tests, but even these tests do not completely rule out a deficiency. Although, the traditional treatment for vitamin B12 deficiency has been intramuscular cobalamin injections, recent studies have shown that oral cobalamin may be as efficacious. SN - 0024-6921 UR - https://www.unboundmedicine.com/medline/citation/19785315/Paralysis_and_pernicious_anemia_in_a_young_woman_ L2 - http://www.diseaseinfosearch.org/result/5584 DB - PRIME DP - Unbound Medicine ER -