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Prevalence of unknown peripheral arterial disease in patients with coronary artery disease: data in primary care from the IPSILON study.
Arch Cardiovasc Dis. 2009 Aug-Sep; 102(8-9):625-31.AC

Abstract

BACKGROUND

Peripheral arterial disease (PAD) is a marker of increased risk of cardiovascular events and of poor prognosis in patients with coronary artery disease (CAD). The prevalence of unknown PAD among patients with CAD varies between studies according to the mode of diagnosis.

AIMS

To evaluate the prevalence of unknown PAD, diagnosed using the ankle-brachial index (ABI), in patients from the IPSILON study with a CAD diagnosis; to assess the profile of these patients; and to determine predictors of PAD.

METHODS

IPSILON was an observational, cross-sectional study. General practitioners measured ABI in 5679 consecutive adults aged 55 years or over with signs or symptoms suggestive of PAD (21.3%), a history of an atherothrombotic event (42.1%) or two or more cardiovascular risk factors (36.6%). This analysis focuses on the subgroup of patients with CAD and no other known overt atherothrombotic disease.

RESULTS

A total of 1340 patients presented with isolated CAD. PAD (ABI<0.90) was diagnosed in 26.6% of these patients; 16.2% were asymptomatic. Older age, symptoms suggestive of PAD and cardiovascular risk factors were found to be independent predictors of PAD in multivariable analysis.

CONCLUSION

Over 26% of patients with CAD present with unknown PAD, as diagnosed using ABI measurement. More than half of these patients are asymptomatic. Screening for PAD in patients with CAD will allow detection of a subpopulation at particularly high cardiovascular risk. An aggressive medical treatment strategy could help to improve their outcome.

Authors+Show Affiliations

s.kownator@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19786266

Citation

Kownator, Serge, et al. "Prevalence of Unknown Peripheral Arterial Disease in Patients With Coronary Artery Disease: Data in Primary Care From the IPSILON Study." Archives of Cardiovascular Diseases, vol. 102, no. 8-9, 2009, pp. 625-31.
Kownator S, Cambou JP, Cacoub P, et al. Prevalence of unknown peripheral arterial disease in patients with coronary artery disease: data in primary care from the IPSILON study. Arch Cardiovasc Dis. 2009;102(8-9):625-31.
Kownator, S., Cambou, J. P., Cacoub, P., Léger, P., Luizy, F., Herrmann, M. A., & Priollet, P. (2009). Prevalence of unknown peripheral arterial disease in patients with coronary artery disease: data in primary care from the IPSILON study. Archives of Cardiovascular Diseases, 102(8-9), 625-31. https://doi.org/10.1016/j.acvd.2009.05.004
Kownator S, et al. Prevalence of Unknown Peripheral Arterial Disease in Patients With Coronary Artery Disease: Data in Primary Care From the IPSILON Study. Arch Cardiovasc Dis. 2009 Aug-Sep;102(8-9):625-31. PubMed PMID: 19786266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of unknown peripheral arterial disease in patients with coronary artery disease: data in primary care from the IPSILON study. AU - Kownator,Serge, AU - Cambou,Jean-Pierre, AU - Cacoub,Patrice, AU - Léger,Philippe, AU - Luizy,François, AU - Herrmann,Marie-Annick, AU - Priollet,Pascal, Y1 - 2009/09/17/ PY - 2009/02/24/received PY - 2009/05/06/revised PY - 2009/05/18/accepted PY - 2009/9/30/entrez PY - 2009/9/30/pubmed PY - 2009/12/16/medline SP - 625 EP - 31 JF - Archives of cardiovascular diseases JO - Arch Cardiovasc Dis VL - 102 IS - 8-9 N2 - BACKGROUND: Peripheral arterial disease (PAD) is a marker of increased risk of cardiovascular events and of poor prognosis in patients with coronary artery disease (CAD). The prevalence of unknown PAD among patients with CAD varies between studies according to the mode of diagnosis. AIMS: To evaluate the prevalence of unknown PAD, diagnosed using the ankle-brachial index (ABI), in patients from the IPSILON study with a CAD diagnosis; to assess the profile of these patients; and to determine predictors of PAD. METHODS: IPSILON was an observational, cross-sectional study. General practitioners measured ABI in 5679 consecutive adults aged 55 years or over with signs or symptoms suggestive of PAD (21.3%), a history of an atherothrombotic event (42.1%) or two or more cardiovascular risk factors (36.6%). This analysis focuses on the subgroup of patients with CAD and no other known overt atherothrombotic disease. RESULTS: A total of 1340 patients presented with isolated CAD. PAD (ABI<0.90) was diagnosed in 26.6% of these patients; 16.2% were asymptomatic. Older age, symptoms suggestive of PAD and cardiovascular risk factors were found to be independent predictors of PAD in multivariable analysis. CONCLUSION: Over 26% of patients with CAD present with unknown PAD, as diagnosed using ABI measurement. More than half of these patients are asymptomatic. Screening for PAD in patients with CAD will allow detection of a subpopulation at particularly high cardiovascular risk. An aggressive medical treatment strategy could help to improve their outcome. SN - 1875-2136 UR - https://www.unboundmedicine.com/medline/citation/19786266/Prevalence_of_unknown_peripheral_arterial_disease_in_patients_with_coronary_artery_disease:_data_in_primary_care_from_the_IPSILON_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-2136(09)00187-9 DB - PRIME DP - Unbound Medicine ER -