Tags

Type your tag names separated by a space and hit enter

Maternal overweight before pregnancy and asthma in offspring followed for 8 years.
Int J Obes (Lond). 2010 Apr; 34(4):606-13.IJ

Abstract

OBJECTIVE

The aim of this study was to investigate the association between maternal overweight before pregnancy and offspring asthma in an ongoing birth cohort study. Maternal overweight may affect the pulmonary and immunological development of the fetus in utero because of the increased levels of inflammatory factors associated with being overweight and thereby increase the asthma risk in childhood.

DESIGN

Birth cohort study with follow-up until 8 years of age.

SUBJECTS

The study population included 3963 children and their mothers who participated in the Prevention and Incidence of Asthma and Mite Allergy study.

MEASUREMENTS

Maternal overweight before pregnancy was defined as a body mass index (BMI) above 25 kg m(-2). Data on wheeze, dyspnea and prescription of inhaled corticosteroids of the child were reported yearly by the parents in a questionnaire. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years. Effect modification by predisposition for asthma in the child was tested. Data were analyzed by logistic regression and generalized estimating equations analyses.

RESULTS

At 8 years, 14.4% (n=571) of the children had asthma. In total, 20.9% (n=830) of the mothers were overweight before pregnancy. In children predisposed for asthma (n=1058), maternal overweight before pregnancy was associated with an increased risk of asthma in the child at 8 years (OR=1.52, 95% CI: 1.05-2.18) after adjustment for confounding factors, birth weight and the child's BMI. No association was observed in children without a predisposition (OR=0.86, 95% CI: 0.60-1.23). There was no association with sensitization or BHR.

CONCLUSION

Children with a predisposition for asthma may have a higher risk to develop asthma during childhood when their mothers are overweight before pregnancy, irrespective of the child's BMI.

Authors+Show Affiliations

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. s.scholtens@epi.umcg.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19786965

Citation

Scholtens, S, et al. "Maternal Overweight Before Pregnancy and Asthma in Offspring Followed for 8 Years." International Journal of Obesity (2005), vol. 34, no. 4, 2010, pp. 606-13.
Scholtens S, Wijga AH, Brunekreef B, et al. Maternal overweight before pregnancy and asthma in offspring followed for 8 years. Int J Obes (Lond). 2010;34(4):606-13.
Scholtens, S., Wijga, A. H., Brunekreef, B., Kerkhof, M., Postma, D. S., Oldenwening, M., de Jongste, J. C., & Smit, H. A. (2010). Maternal overweight before pregnancy and asthma in offspring followed for 8 years. International Journal of Obesity (2005), 34(4), 606-13. https://doi.org/10.1038/ijo.2009.194
Scholtens S, et al. Maternal Overweight Before Pregnancy and Asthma in Offspring Followed for 8 Years. Int J Obes (Lond). 2010;34(4):606-13. PubMed PMID: 19786965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal overweight before pregnancy and asthma in offspring followed for 8 years. AU - Scholtens,S, AU - Wijga,A H, AU - Brunekreef,B, AU - Kerkhof,M, AU - Postma,D S, AU - Oldenwening,M, AU - de Jongste,J C, AU - Smit,H A, Y1 - 2009/09/29/ PY - 2009/9/30/entrez PY - 2009/9/30/pubmed PY - 2010/10/28/medline SP - 606 EP - 13 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 34 IS - 4 N2 - OBJECTIVE: The aim of this study was to investigate the association between maternal overweight before pregnancy and offspring asthma in an ongoing birth cohort study. Maternal overweight may affect the pulmonary and immunological development of the fetus in utero because of the increased levels of inflammatory factors associated with being overweight and thereby increase the asthma risk in childhood. DESIGN: Birth cohort study with follow-up until 8 years of age. SUBJECTS: The study population included 3963 children and their mothers who participated in the Prevention and Incidence of Asthma and Mite Allergy study. MEASUREMENTS: Maternal overweight before pregnancy was defined as a body mass index (BMI) above 25 kg m(-2). Data on wheeze, dyspnea and prescription of inhaled corticosteroids of the child were reported yearly by the parents in a questionnaire. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years. Effect modification by predisposition for asthma in the child was tested. Data were analyzed by logistic regression and generalized estimating equations analyses. RESULTS: At 8 years, 14.4% (n=571) of the children had asthma. In total, 20.9% (n=830) of the mothers were overweight before pregnancy. In children predisposed for asthma (n=1058), maternal overweight before pregnancy was associated with an increased risk of asthma in the child at 8 years (OR=1.52, 95% CI: 1.05-2.18) after adjustment for confounding factors, birth weight and the child's BMI. No association was observed in children without a predisposition (OR=0.86, 95% CI: 0.60-1.23). There was no association with sensitization or BHR. CONCLUSION: Children with a predisposition for asthma may have a higher risk to develop asthma during childhood when their mothers are overweight before pregnancy, irrespective of the child's BMI. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/19786965/Maternal_overweight_before_pregnancy_and_asthma_in_offspring_followed_for_8_years_ L2 - https://doi.org/10.1038/ijo.2009.194 DB - PRIME DP - Unbound Medicine ER -