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[Trans fatty acids: effects on lipoprotein metabolism and cardiovascular risk].

Abstract

Dietary trans fatty acids (TFA) (mainly 18:1 isomers) have two sources: they are formed during the natural bacterial hydrogenation of unsaturated fatty acids in ruminants or they come from the industrial hydrogenation of unsaturated vegetable oils. Total trans fatty acids account for 1.3% of total energy intake in France compared to 2-3% in USA. Recent epidemiologic studies and meta-analyses of well-designed controlled trials clearly showed that trans fatty acids are associated with an increase of cardiovascular risk. It seems that TFA from industrial sources are responsible for the deleterious effects particularly on lipoprotein metabolism. Specifically the consumption of industrial TFA has been associated with high plasma concentrations of triacylglycerols, LDL-cholesterol and small dense LDL and lower HDL-cholesterol concentrations. The very recent interventional trials allowed for a comparison of TFAs from different sources suggest that the intake of natural TFA have no or neutral effects on plasma lipids and other cardiovascular risk factors. However, the mechanisms underlying the isomer-specific effects are not well understood and warrant further investigations.

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  • Authors+Show Affiliations

    ,

    Université Paris-Sud, UMR INRA 1154, UFR de pharmacie, Châtenay-Malabry.

    , ,

    Source

    MeSH

    Cardiovascular Diseases
    Cholesterol
    Dietary Fats
    Humans
    Hyperlipidemias
    Lipid Metabolism
    Trans Fatty Acids

    Pub Type(s)

    English Abstract
    Journal Article
    Review

    Language

    fre

    PubMed ID

    19789123

    Citation

    Attia-Skhiri, N, et al. "[Trans Fatty Acids: Effects On Lipoprotein Metabolism and Cardiovascular Risk]." Annales De Biologie Clinique, vol. 67, no. 5, 2009, pp. 517-23.
    Attia-Skhiri N, Fournier N, Pourci ML, et al. [Trans fatty acids: effects on lipoprotein metabolism and cardiovascular risk]. Ann Biol Clin (Paris). 2009;67(5):517-23.
    Attia-Skhiri, N., Fournier, N., Pourci, M. L., & Paul, J. L. (2009). [Trans fatty acids: effects on lipoprotein metabolism and cardiovascular risk]. Annales De Biologie Clinique, 67(5), pp. 517-23. doi:10.1684/abc.2009.0358.
    Attia-Skhiri N, et al. [Trans Fatty Acids: Effects On Lipoprotein Metabolism and Cardiovascular Risk]. Ann Biol Clin (Paris). 2009;67(5):517-23. PubMed PMID: 19789123.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Trans fatty acids: effects on lipoprotein metabolism and cardiovascular risk]. AU - Attia-Skhiri,N, AU - Fournier,N, AU - Pourci,M-L, AU - Paul,J-L, PY - 2009/10/1/entrez PY - 2009/10/1/pubmed PY - 2009/12/16/medline SP - 517 EP - 23 JF - Annales de biologie clinique JO - Ann. Biol. Clin. (Paris) VL - 67 IS - 5 N2 - Dietary trans fatty acids (TFA) (mainly 18:1 isomers) have two sources: they are formed during the natural bacterial hydrogenation of unsaturated fatty acids in ruminants or they come from the industrial hydrogenation of unsaturated vegetable oils. Total trans fatty acids account for 1.3% of total energy intake in France compared to 2-3% in USA. Recent epidemiologic studies and meta-analyses of well-designed controlled trials clearly showed that trans fatty acids are associated with an increase of cardiovascular risk. It seems that TFA from industrial sources are responsible for the deleterious effects particularly on lipoprotein metabolism. Specifically the consumption of industrial TFA has been associated with high plasma concentrations of triacylglycerols, LDL-cholesterol and small dense LDL and lower HDL-cholesterol concentrations. The very recent interventional trials allowed for a comparison of TFAs from different sources suggest that the intake of natural TFA have no or neutral effects on plasma lipids and other cardiovascular risk factors. However, the mechanisms underlying the isomer-specific effects are not well understood and warrant further investigations. SN - 0003-3898 UR - https://www.unboundmedicine.com/medline/citation/19789123/[Trans_fatty_acids:_effects_on_lipoprotein_metabolism_and_cardiovascular_risk]_ L2 - http://www.jle.com/medline.md?issn=0003-3898&vol=67&iss=5&page=517 DB - PRIME DP - Unbound Medicine ER -