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[Study of antigenic profile of blasts in acute lymphoblastic leukemia: flow cytometric analysis of 152 cases].
Ann Biol Clin (Paris). 2009 Sep-Oct; 67(5):543-51.AB

Abstract

The aim of this study was to characterize the antigenic profile of blasts in acute lymphoblastic leukaemia (ALL) and to determine possible phenotypic aberrancies in a series of 152 patients with acute leukaemia diagnosed non myeloid leukaemia in cytology. Samples were analyzed by EPICS XL flow cytometer (Beckman Coulter) after staining with monoclonal antibodies(Beckman Coulter). Based on criteria of EGIL (European Group of Immunological Leukaemia), cases were classified as: acute lymphoblastic leukaemia (ALL, 52,6%); 75% cases of ALL belong to lymphoid B lineage. 80% of ALL B were CD10 positive, marker of best prognosis. In 10,5% of cases, biphenotypic leukaemia is diagnosed (lymphoid/myeloid). In 25% of cases aberrancies in phenotype were found. Flow cytometry has wide field of applications to characterize blast cells from patients with acute leukaemia: to establish diagnosis of lineage responsible in proliferation, to determine the stage of maturation, to predict prognosis for a better adaptation of adequate treatment, to follow evolution of disease after chemotherapy and to study minimal residual disease.

Authors+Show Affiliations

Laboratoire d'hématologie, CHU Farhat Hached, Sousse, Tunisie. jmillinejia@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

19789126

Citation

Jmili, N Braham, et al. "[Study of Antigenic Profile of Blasts in Acute Lymphoblastic Leukemia: Flow Cytometric Analysis of 152 Cases]." Annales De Biologie Clinique, vol. 67, no. 5, 2009, pp. 543-51.
Jmili NB, Souguir S, Yacoub S, et al. [Study of antigenic profile of blasts in acute lymphoblastic leukemia: flow cytometric analysis of 152 cases]. Ann Biol Clin (Paris). 2009;67(5):543-51.
Jmili, N. B., Souguir, S., Yacoub, S., Khelif, A., & Kortas, M. (2009). [Study of antigenic profile of blasts in acute lymphoblastic leukemia: flow cytometric analysis of 152 cases]. Annales De Biologie Clinique, 67(5), 543-51. https://doi.org/10.1684/abc.2009.0361
Jmili NB, et al. [Study of Antigenic Profile of Blasts in Acute Lymphoblastic Leukemia: Flow Cytometric Analysis of 152 Cases]. Ann Biol Clin (Paris). 2009 Sep-Oct;67(5):543-51. PubMed PMID: 19789126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of antigenic profile of blasts in acute lymphoblastic leukemia: flow cytometric analysis of 152 cases]. AU - Jmili,N Braham, AU - Souguir,S, AU - Yacoub,S, AU - Khelif,A, AU - Kortas,M, PY - 2009/10/1/entrez PY - 2009/10/1/pubmed PY - 2009/12/16/medline SP - 543 EP - 51 JF - Annales de biologie clinique JO - Ann Biol Clin (Paris) VL - 67 IS - 5 N2 - The aim of this study was to characterize the antigenic profile of blasts in acute lymphoblastic leukaemia (ALL) and to determine possible phenotypic aberrancies in a series of 152 patients with acute leukaemia diagnosed non myeloid leukaemia in cytology. Samples were analyzed by EPICS XL flow cytometer (Beckman Coulter) after staining with monoclonal antibodies(Beckman Coulter). Based on criteria of EGIL (European Group of Immunological Leukaemia), cases were classified as: acute lymphoblastic leukaemia (ALL, 52,6%); 75% cases of ALL belong to lymphoid B lineage. 80% of ALL B were CD10 positive, marker of best prognosis. In 10,5% of cases, biphenotypic leukaemia is diagnosed (lymphoid/myeloid). In 25% of cases aberrancies in phenotype were found. Flow cytometry has wide field of applications to characterize blast cells from patients with acute leukaemia: to establish diagnosis of lineage responsible in proliferation, to determine the stage of maturation, to predict prognosis for a better adaptation of adequate treatment, to follow evolution of disease after chemotherapy and to study minimal residual disease. SN - 0003-3898 UR - https://www.unboundmedicine.com/medline/citation/19789126/[Study_of_antigenic_profile_of_blasts_in_acute_lymphoblastic_leukemia:_flow_cytometric_analysis_of_152_cases]_ L2 - http://www.jle.com/medline.md?issn=0003-3898&vol=67&iss=5&page=543 DB - PRIME DP - Unbound Medicine ER -