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Antinucleosome antibodies in juvenile chronic arthritis.
Clin Rheumatol. 2009 Dec; 28(12):1461-3.CR

Abstract

A broad range of autoantibodies have been detected in juvenile chronic arthritis (JCA) patients, although, none of them can be considered specific for this entity. Antinuclear antibody (ANA) is routinely searched in these patients mainly because it is associated with uveitis, a comorbidity that is particularly frequent in the oligoarticular form. Nevertheless, the ANA specific antigen target in JCA is unknown. In this study, we aimed to search for antinucleosome antibodies in 30 adult JCA patients and to study possible associations with clinical profile. Ten individuals (33.3%) were positive for antinucleosome antibodies and seven (70%) were simultaneously ANA positive (p = 0.01). We did not find any significant association among antinucleosome and JCA form, uveitis, age of onset, gender, or functional index. We conclude that in JCA, there is a prevalence of 33.3% of antinucleosome antibodies. Further investigations are needed to understand the ANA positivity found in this disease as far as the clinical impact of this finding.

Authors

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Pub Type(s)

Letter

Language

eng

PubMed ID

19789936

Citation

Nisihara, Renato M., et al. "Antinucleosome Antibodies in Juvenile Chronic Arthritis." Clinical Rheumatology, vol. 28, no. 12, 2009, pp. 1461-3.
Nisihara RM, Skare T, Silva MB, et al. Antinucleosome antibodies in juvenile chronic arthritis. Clin Rheumatol. 2009;28(12):1461-3.
Nisihara, R. M., Skare, T., Silva, M. B., Silva, R. M., & Silva, D. J. (2009). Antinucleosome antibodies in juvenile chronic arthritis. Clinical Rheumatology, 28(12), 1461-3. https://doi.org/10.1007/s10067-009-1282-0
Nisihara RM, et al. Antinucleosome Antibodies in Juvenile Chronic Arthritis. Clin Rheumatol. 2009;28(12):1461-3. PubMed PMID: 19789936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinucleosome antibodies in juvenile chronic arthritis. AU - Nisihara,Renato M, AU - Skare,Thelma, AU - Silva,Marilia Barreto, AU - Silva,Rafael Mourato, AU - Silva,Danilo J Munhoz, Y1 - 2009/09/30/ PY - 2009/06/22/received PY - 2009/09/15/accepted PY - 2009/09/09/revised PY - 2009/10/1/entrez PY - 2009/10/1/pubmed PY - 2010/3/31/medline SP - 1461 EP - 3 JF - Clinical rheumatology JO - Clin Rheumatol VL - 28 IS - 12 N2 - A broad range of autoantibodies have been detected in juvenile chronic arthritis (JCA) patients, although, none of them can be considered specific for this entity. Antinuclear antibody (ANA) is routinely searched in these patients mainly because it is associated with uveitis, a comorbidity that is particularly frequent in the oligoarticular form. Nevertheless, the ANA specific antigen target in JCA is unknown. In this study, we aimed to search for antinucleosome antibodies in 30 adult JCA patients and to study possible associations with clinical profile. Ten individuals (33.3%) were positive for antinucleosome antibodies and seven (70%) were simultaneously ANA positive (p = 0.01). We did not find any significant association among antinucleosome and JCA form, uveitis, age of onset, gender, or functional index. We conclude that in JCA, there is a prevalence of 33.3% of antinucleosome antibodies. Further investigations are needed to understand the ANA positivity found in this disease as far as the clinical impact of this finding. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/19789936/Antinucleosome_antibodies_in_juvenile_chronic_arthritis_ L2 - https://dx.doi.org/10.1007/s10067-009-1282-0 DB - PRIME DP - Unbound Medicine ER -