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Effects of acute and chronic ethanol administration and its withdrawal on the level and binding of somatostatin in rat brain.
Clin Sci (Lond). 1990 Nov; 79(5):451-6.CS

Abstract

1. Acute ethanol administration resulted in an increase in the total number of specific somatostatin receptors in rat frontoparietal cortex and hippocampus, and a decrease in the level of somatostatin-like immunoreactivity in the hippocampus but not in the frontoparietal cortex. 2. Chronic administration of ethanol caused a decrease in the number of somatostatin receptors in the frontoparietal cortex but not in the hippocampus, although the level of somatostatin-like immunoreactivity was unchanged in both brain areas. 3. A week after suppressing ethanol the value for specific binding of tracer to somatostatin receptors in the frontoparietal cortex was not significantly different from that of the control rats, although the actual number of receptors was slightly lower. 4. These results suggest a possible role for somatostatin in the nervous system during alcoholism and the post-withdrawal reaction.

Authors+Show Affiliations

Barrios V
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcalá, Madrid, Spain.
Rodríguez-Sánchez MN
No affiliation info available
Arilla E
No affiliation info available

MeSH

AnimalsBrainEthanolFrontal LobeHippocampusMaleRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinSomatostatinSubstance Withdrawal Syndrome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1979022

Citation

Barrios, V, et al. "Effects of Acute and Chronic Ethanol Administration and Its Withdrawal On the Level and Binding of Somatostatin in Rat Brain." Clinical Science (London, England : 1979), vol. 79, no. 5, 1990, pp. 451-6.
Barrios V, Rodríguez-Sánchez MN, Arilla E. Effects of acute and chronic ethanol administration and its withdrawal on the level and binding of somatostatin in rat brain. Clin Sci (Lond). 1990;79(5):451-6.
Barrios, V., Rodríguez-Sánchez, M. N., & Arilla, E. (1990). Effects of acute and chronic ethanol administration and its withdrawal on the level and binding of somatostatin in rat brain. Clinical Science (London, England : 1979), 79(5), 451-6.
Barrios V, Rodríguez-Sánchez MN, Arilla E. Effects of Acute and Chronic Ethanol Administration and Its Withdrawal On the Level and Binding of Somatostatin in Rat Brain. Clin Sci (Lond). 1990;79(5):451-6. PubMed PMID: 1979022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute and chronic ethanol administration and its withdrawal on the level and binding of somatostatin in rat brain. AU - Barrios,V, AU - Rodríguez-Sánchez,M N, AU - Arilla,E, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 451 EP - 6 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 79 IS - 5 N2 - 1. Acute ethanol administration resulted in an increase in the total number of specific somatostatin receptors in rat frontoparietal cortex and hippocampus, and a decrease in the level of somatostatin-like immunoreactivity in the hippocampus but not in the frontoparietal cortex. 2. Chronic administration of ethanol caused a decrease in the number of somatostatin receptors in the frontoparietal cortex but not in the hippocampus, although the level of somatostatin-like immunoreactivity was unchanged in both brain areas. 3. A week after suppressing ethanol the value for specific binding of tracer to somatostatin receptors in the frontoparietal cortex was not significantly different from that of the control rats, although the actual number of receptors was slightly lower. 4. These results suggest a possible role for somatostatin in the nervous system during alcoholism and the post-withdrawal reaction. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/1979022/Effects_of_acute_and_chronic_ethanol_administration_and_its_withdrawal_on_the_level_and_binding_of_somatostatin_in_rat_brain_ DB - PRIME DP - Unbound Medicine ER -