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[Effects of statins on coronary atherosclerotic plaque in patients with coronary heart disease and type 2 diabetes with mild elevated LDL-C].
Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Apr; 37(4):339-42.ZX

Abstract

OBJECTIVE

To evaluate the effects of statins on coronary atherosclerotic plaque in patients with stable angina pectoris and type 2 diabetes with mild elevated low density lipoprotein-cholesterol (LDL-C).

METHODS

Seventy-eight patients with stable angina pectoris and type 2 diabetes mellitus and mild elevated LDL-C were treated with (n=40) or without (n=38) statins for 12 months. Coronary artery angiography (CAG) and intravascular ultrasound (IVUS) were performed at baseline and after 12 months on lesion and reference segment to compare the plaque volume, lumen volume, vascular volume and remodeling index was calculated as vascular volume index (VVI) at lesion divided by VVI at reference segment One coronary lesion with 50%-70% stenosis was selected as target plaque in each patient.

RESULTS

Baseline clinical and angiographic data were comparable between the two groups. After 12 months, LDL-C decreased 31.5% in statin group and remained unchanged in non-statin group. After 12 months, plaque volume was significantly increased [ (76.1 +/- 13.0) mm3 vs. (95.0 +/- 21.9) mm3 , P < 0.05], lumen volume was significantly decreased [(65.0 +/- 10.9) mm3 vs. (45.4 +/- 6.6) mm3, P < 0.05 ] and vascular volume remained unchanged in non-statins group; plaque volume was also significantly increased [(79.5 +/- 15.2) mm3 vs. (87.5 +/- 17.9) mm3 , P < 0.05] while lumen volume and vascular volume remained unchanged in statin group. Remodeling index (RI) remained unchanged in non-statin group but significantly increased in statin group (0.91 +/- 0.08 vs. 0.95 +/- 0.10, P < 0.05) after 12 months.

CONCLUSION

Chronic statin therapy could retard the coronary atherosclerotic progression in patients with stable angina pectoris and type 2 diabetes with mild elevated LDL-C.

Authors+Show Affiliations

Department of Cardiology, Tianjin First Central Hospital, Clinical College of Tianjin Medical University, Tianjin 300192, China. wangxiaofei@medmail.com.cnNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

chi

PubMed ID

19791470

Citation

Wang, Xiao-fei, et al. "[Effects of Statins On Coronary Atherosclerotic Plaque in Patients With Coronary Heart Disease and Type 2 Diabetes With Mild Elevated LDL-C]." Zhonghua Xin Xue Guan Bing Za Zhi, vol. 37, no. 4, 2009, pp. 339-42.
Wang XF, Lu CZ, Chen X. [Effects of statins on coronary atherosclerotic plaque in patients with coronary heart disease and type 2 diabetes with mild elevated LDL-C]. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37(4):339-42.
Wang, X. F., Lu, C. Z., & Chen, X. (2009). [Effects of statins on coronary atherosclerotic plaque in patients with coronary heart disease and type 2 diabetes with mild elevated LDL-C]. Zhonghua Xin Xue Guan Bing Za Zhi, 37(4), 339-42.
Wang XF, Lu CZ, Chen X. [Effects of Statins On Coronary Atherosclerotic Plaque in Patients With Coronary Heart Disease and Type 2 Diabetes With Mild Elevated LDL-C]. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37(4):339-42. PubMed PMID: 19791470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of statins on coronary atherosclerotic plaque in patients with coronary heart disease and type 2 diabetes with mild elevated LDL-C]. AU - Wang,Xiao-fei, AU - Lu,Cheng-zhi, AU - Chen,Xin, PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2010/1/8/medline SP - 339 EP - 42 JF - Zhonghua xin xue guan bing za zhi JO - Zhonghua Xin Xue Guan Bing Za Zhi VL - 37 IS - 4 N2 - OBJECTIVE: To evaluate the effects of statins on coronary atherosclerotic plaque in patients with stable angina pectoris and type 2 diabetes with mild elevated low density lipoprotein-cholesterol (LDL-C). METHODS: Seventy-eight patients with stable angina pectoris and type 2 diabetes mellitus and mild elevated LDL-C were treated with (n=40) or without (n=38) statins for 12 months. Coronary artery angiography (CAG) and intravascular ultrasound (IVUS) were performed at baseline and after 12 months on lesion and reference segment to compare the plaque volume, lumen volume, vascular volume and remodeling index was calculated as vascular volume index (VVI) at lesion divided by VVI at reference segment One coronary lesion with 50%-70% stenosis was selected as target plaque in each patient. RESULTS: Baseline clinical and angiographic data were comparable between the two groups. After 12 months, LDL-C decreased 31.5% in statin group and remained unchanged in non-statin group. After 12 months, plaque volume was significantly increased [ (76.1 +/- 13.0) mm3 vs. (95.0 +/- 21.9) mm3 , P < 0.05], lumen volume was significantly decreased [(65.0 +/- 10.9) mm3 vs. (45.4 +/- 6.6) mm3, P < 0.05 ] and vascular volume remained unchanged in non-statins group; plaque volume was also significantly increased [(79.5 +/- 15.2) mm3 vs. (87.5 +/- 17.9) mm3 , P < 0.05] while lumen volume and vascular volume remained unchanged in statin group. Remodeling index (RI) remained unchanged in non-statin group but significantly increased in statin group (0.91 +/- 0.08 vs. 0.95 +/- 0.10, P < 0.05) after 12 months. CONCLUSION: Chronic statin therapy could retard the coronary atherosclerotic progression in patients with stable angina pectoris and type 2 diabetes with mild elevated LDL-C. SN - 0253-3758 UR - https://www.unboundmedicine.com/medline/citation/19791470/[Effects_of_statins_on_coronary_atherosclerotic_plaque_in_patients_with_coronary_heart_disease_and_type_2_diabetes_with_mild_elevated_LDL_C]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3758&amp;year=2009&amp;vol=37&amp;issue=4&amp;fpage=339 DB - PRIME DP - Unbound Medicine ER -