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Effects of acute and chronic cocaine administration on somatostatin level and binding in the rat brain.
Neuropeptides. 1990 May; 16(1):1-7.N

Abstract

The effects of acute and chronic cocaine (40 mg/Kg i.p.) in vivo administration, on 125I-Tyr11-somatostatin binding and somatostatin-like immunoreactivity (SLI) in the rat frontoparietal cortex, hippocampus and olfactory bulb were explored. Acute and chronic cocaine administration did not affect the levels of SLI in the three brain areas studied. Acute cocaine administration resulted in an 55% and 32% decrease in the total number of specific somatostatin receptors in the hippocampus and olfactory bulb respectively, but not in the frontoparietal cortex. Somatostatin receptor affinity increased in the hippocampus and was unaltered in frontoparietal cortex and olfactory bulb. After two weeks of daily cocaine injections the somatostatin binding in the hippocampus and olfactory bulb returned to control values. The in vitro addition of cocaine to a brain membrane preparation obtained from untreated rats did not markedly affect somatostatin binding characteristics. These results are suggestive of a possible role for somatostatin in the limbic structures as a response to cocaine administration.

Authors+Show Affiliations

Rodriguez-Sanchez MN
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcala, Madrid, Spain.
Arilla E
No affiliation info available

MeSH

AnimalsBinding, CompetitiveBrainCell MembraneCocaineCulture MediaMathematicsOsmolar ConcentrationRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinSomatostatinTime FactorsTissue Distribution

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1979155

Citation

Rodriguez-Sanchez, M N., and E Arilla. "Effects of Acute and Chronic Cocaine Administration On Somatostatin Level and Binding in the Rat Brain." Neuropeptides, vol. 16, no. 1, 1990, pp. 1-7.
Rodriguez-Sanchez MN, Arilla E. Effects of acute and chronic cocaine administration on somatostatin level and binding in the rat brain. Neuropeptides. 1990;16(1):1-7.
Rodriguez-Sanchez, M. N., & Arilla, E. (1990). Effects of acute and chronic cocaine administration on somatostatin level and binding in the rat brain. Neuropeptides, 16(1), 1-7.
Rodriguez-Sanchez MN, Arilla E. Effects of Acute and Chronic Cocaine Administration On Somatostatin Level and Binding in the Rat Brain. Neuropeptides. 1990;16(1):1-7. PubMed PMID: 1979155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute and chronic cocaine administration on somatostatin level and binding in the rat brain. AU - Rodriguez-Sanchez,M N, AU - Arilla,E, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 1 EP - 7 JF - Neuropeptides JO - Neuropeptides VL - 16 IS - 1 N2 - The effects of acute and chronic cocaine (40 mg/Kg i.p.) in vivo administration, on 125I-Tyr11-somatostatin binding and somatostatin-like immunoreactivity (SLI) in the rat frontoparietal cortex, hippocampus and olfactory bulb were explored. Acute and chronic cocaine administration did not affect the levels of SLI in the three brain areas studied. Acute cocaine administration resulted in an 55% and 32% decrease in the total number of specific somatostatin receptors in the hippocampus and olfactory bulb respectively, but not in the frontoparietal cortex. Somatostatin receptor affinity increased in the hippocampus and was unaltered in frontoparietal cortex and olfactory bulb. After two weeks of daily cocaine injections the somatostatin binding in the hippocampus and olfactory bulb returned to control values. The in vitro addition of cocaine to a brain membrane preparation obtained from untreated rats did not markedly affect somatostatin binding characteristics. These results are suggestive of a possible role for somatostatin in the limbic structures as a response to cocaine administration. SN - 0143-4179 UR - https://www.unboundmedicine.com/medline/citation/1979155/Effects_of_acute_and_chronic_cocaine_administration_on_somatostatin_level_and_binding_in_the_rat_brain_ DB - PRIME DP - Unbound Medicine ER -