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Hyperoxic interval training in chronic obstructive pulmonary disease patients with oxygen desaturation at peak exercise.
Scand J Med Sci Sports. 2010 Feb; 20(1):e170-6.SJ

Abstract

High-intensity work might not be preserved in chronic obstructive pulmonary disease (COPD) during whole-body exercise due to ventilatory limitations that exceed metabolic limitations, resulting in reduced training adaptations. The purpose of the present study was to address the hyperoxic effect during training and testing in COPD patients with hypoxemia at peak exercise. Six COPD and eight coronary artery disease (CAD) patients completed 24 aerobic high-intensity interval training sessions, 4x4 min in hyperoxia at 85-95% of the peak heart rate and peak exercise tested in normoxia and hyperoxia pre- and post-training. VO2peak increased in the COPD group by 19% (13-31%) and in the CAD group by 15% (7-29%), [0.98(0.68-1.52)-1.17(0.89-1.78) and 2.11(1.57-2.64)-2.44(1.92-3.39) L/min], respectively. VO2peak was higher in hyperoxia at pre- and post-test (1.22(0.80-1.87) and 1.37(1.01-1.94) L/min) in the COPD group. Work economy improved by 10% in both groups. Quality of life improved in the COPD group in terms of physical and mental health status by 24% and 35%. Hyperoxic aerobic high-intensity interval training in COPD patients with hypoxemia at peak exercise increases VO2peak, peak workload, work economy and quality of life. Acute hyperoxia increases VO2peak, peak workload at pre- and post-test compared with normoxia in the COPD patients, indicating an oxygen supply limitation to VO2peak.

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Authors+Show Affiliations

Helgerud J
Faculty of Medicine, Norwegian University of Science and Technology, and Department of Pulmonary Medicine, St. Olav University Hospital, Trondheim, Norway. jan.helgerud@ntnu.no
Bjørgen S
No affiliation info available
Karlsen T
No affiliation info available
Husby VS
No affiliation info available
Steinshamn S
No affiliation info available
Richardson RS
No affiliation info available
Hoff J
No affiliation info available

MeSH

AgedExerciseExercise TestExercise TherapyFemaleHumansHyperoxiaMiddle AgedMuscle, SkeletalOxygenOxygen ConsumptionPulmonary Disease, Chronic ObstructiveQuality of Life

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19793218

Clinical Trial Links

Different Modalities of Exercise Training in COPD With Chronic Respiratory Failure (CRF)

Citation

Helgerud, J, et al. "Hyperoxic Interval Training in Chronic Obstructive Pulmonary Disease Patients With Oxygen Desaturation at Peak Exercise." Scandinavian Journal of Medicine & Science in Sports, vol. 20, no. 1, 2010, pp. e170-6.
Helgerud J, Bjørgen S, Karlsen T, et al. Hyperoxic interval training in chronic obstructive pulmonary disease patients with oxygen desaturation at peak exercise. Scand J Med Sci Sports. 2010;20(1):e170-6.
Helgerud, J., Bjørgen, S., Karlsen, T., Husby, V. S., Steinshamn, S., Richardson, R. S., & Hoff, J. (2010). Hyperoxic interval training in chronic obstructive pulmonary disease patients with oxygen desaturation at peak exercise. Scandinavian Journal of Medicine & Science in Sports, 20(1), e170-6. https://doi.org/10.1111/j.1600-0838.2009.00937.x
Helgerud J, et al. Hyperoxic Interval Training in Chronic Obstructive Pulmonary Disease Patients With Oxygen Desaturation at Peak Exercise. Scand J Med Sci Sports. 2010;20(1):e170-6. PubMed PMID: 19793218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperoxic interval training in chronic obstructive pulmonary disease patients with oxygen desaturation at peak exercise. AU - Helgerud,J, AU - Bjørgen,S, AU - Karlsen,T, AU - Husby,V S, AU - Steinshamn,S, AU - Richardson,R S, AU - Hoff,J, Y1 - 2009/05/26/ PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2010/9/16/medline SP - e170 EP - 6 JF - Scandinavian journal of medicine & science in sports JO - Scand J Med Sci Sports VL - 20 IS - 1 N2 - High-intensity work might not be preserved in chronic obstructive pulmonary disease (COPD) during whole-body exercise due to ventilatory limitations that exceed metabolic limitations, resulting in reduced training adaptations. The purpose of the present study was to address the hyperoxic effect during training and testing in COPD patients with hypoxemia at peak exercise. Six COPD and eight coronary artery disease (CAD) patients completed 24 aerobic high-intensity interval training sessions, 4x4 min in hyperoxia at 85-95% of the peak heart rate and peak exercise tested in normoxia and hyperoxia pre- and post-training. VO2peak increased in the COPD group by 19% (13-31%) and in the CAD group by 15% (7-29%), [0.98(0.68-1.52)-1.17(0.89-1.78) and 2.11(1.57-2.64)-2.44(1.92-3.39) L/min], respectively. VO2peak was higher in hyperoxia at pre- and post-test (1.22(0.80-1.87) and 1.37(1.01-1.94) L/min) in the COPD group. Work economy improved by 10% in both groups. Quality of life improved in the COPD group in terms of physical and mental health status by 24% and 35%. Hyperoxic aerobic high-intensity interval training in COPD patients with hypoxemia at peak exercise increases VO2peak, peak workload, work economy and quality of life. Acute hyperoxia increases VO2peak, peak workload at pre- and post-test compared with normoxia in the COPD patients, indicating an oxygen supply limitation to VO2peak. SN - 1600-0838 UR - https://www.unboundmedicine.com/medline/citation/19793218/Hyperoxic_interval_training_in_chronic_obstructive_pulmonary_disease_patients_with_oxygen_desaturation_at_peak_exercise_ L2 - https://doi.org/10.1111/j.1600-0838.2009.00937.x DB - PRIME DP - Unbound Medicine ER -