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Diagnosis and endoscopic surgery of chronic invasive fungal rhinosinusitis.
Am J Rhinol Allergy. 2009 Nov-Dec; 23(6):622-5.AJ

Abstract

BACKGROUND

Chronic invasive fungal rhinosinusitis (CIFRS) was thought to be a rare fungal disease of the sinus but is becoming increasingly common. Methods for the early diagnosis of CIFRS and treatment efficacy have not been thoroughly explored. This study was designed to summarize the diagnosis and endoscopic surgical treatment of a group of patients with CIFRS.

METHODS

Twenty-eight cases of CIFRS treated by nasal endoscopic sinus surgery between January 2000 and December 2006 were retrospectively analyzed.

RESULTS

Each case underwent nasal endoscopic debridement surgery; six cases with progressive symptomatology were given systemic broad-spectrum antifungal drugs for at least 12 weeks after the operation. Long-term outcome was positive in most cases. Twenty-three cases were cured while five recurred, of which two recurred within 6 months. Four cases underwent further endoscopic surgery, two were subsequently cured, one died of severe intracranial Mucor infection, and one was lost to follow-up. The overall cure rate was 89.3%.

CONCLUSION

Endoscopic surgery is an effective and microinvasive therapy for patients with CIFRS. The procedure includes elimination of the diseased sinus mucosa with or without simultaneous administration of broad-spectrum antifungal medicines. Early diagnosis of CIFRS and surgical nasal sinus debridement can improve prognosis.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. lyqzxc1@163.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19793417

Citation

Li, Yongqi, et al. "Diagnosis and Endoscopic Surgery of Chronic Invasive Fungal Rhinosinusitis." American Journal of Rhinology & Allergy, vol. 23, no. 6, 2009, pp. 622-5.
Li Y, Li Y, Li P, et al. Diagnosis and endoscopic surgery of chronic invasive fungal rhinosinusitis. Am J Rhinol Allergy. 2009;23(6):622-5.
Li, Y., Li, Y., Li, P., & Zhang, G. (2009). Diagnosis and endoscopic surgery of chronic invasive fungal rhinosinusitis. American Journal of Rhinology & Allergy, 23(6), 622-5. https://doi.org/10.2500/ajra.2009.23.3361
Li Y, et al. Diagnosis and Endoscopic Surgery of Chronic Invasive Fungal Rhinosinusitis. Am J Rhinol Allergy. 2009;23(6):622-5. PubMed PMID: 19793417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and endoscopic surgery of chronic invasive fungal rhinosinusitis. AU - Li,Yongqi, AU - Li,Yuan, AU - Li,Peng, AU - Zhang,Gehua, Y1 - 2009/09/29/ PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2010/6/10/medline SP - 622 EP - 5 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 23 IS - 6 N2 - BACKGROUND: Chronic invasive fungal rhinosinusitis (CIFRS) was thought to be a rare fungal disease of the sinus but is becoming increasingly common. Methods for the early diagnosis of CIFRS and treatment efficacy have not been thoroughly explored. This study was designed to summarize the diagnosis and endoscopic surgical treatment of a group of patients with CIFRS. METHODS: Twenty-eight cases of CIFRS treated by nasal endoscopic sinus surgery between January 2000 and December 2006 were retrospectively analyzed. RESULTS: Each case underwent nasal endoscopic debridement surgery; six cases with progressive symptomatology were given systemic broad-spectrum antifungal drugs for at least 12 weeks after the operation. Long-term outcome was positive in most cases. Twenty-three cases were cured while five recurred, of which two recurred within 6 months. Four cases underwent further endoscopic surgery, two were subsequently cured, one died of severe intracranial Mucor infection, and one was lost to follow-up. The overall cure rate was 89.3%. CONCLUSION: Endoscopic surgery is an effective and microinvasive therapy for patients with CIFRS. The procedure includes elimination of the diseased sinus mucosa with or without simultaneous administration of broad-spectrum antifungal medicines. Early diagnosis of CIFRS and surgical nasal sinus debridement can improve prognosis. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/19793417/Diagnosis_and_endoscopic_surgery_of_chronic_invasive_fungal_rhinosinusitis_ L2 - http://journals.sagepub.com/doi/full/10.2500/ajra.2009.23.3361?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -