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Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults.
Am J Clin Nutr. 2009 Nov; 90(5):1138-43.AJ

Abstract

BACKGROUND

The ability of modified alternate-day fasting (ADF; ie, consuming 25% of energy needs on the fast day and ad libitum food intake on the following day) to facilitate weight loss and lower vascular disease risk in obese individuals remains unknown.

OBJECTIVE

This study examined the effects of ADF that is administered under controlled compared with self-implemented conditions on body weight and coronary artery disease (CAD) risk indicators in obese adults.

DESIGN

Sixteen obese subjects (12 women, 4 men) completed a 10-wk trial, which consisted of 3 phases: 1) a 2-wk control phase, 2) a 4-wk weight loss/ADF controlled food intake phase, and 3) a 4-wk weight loss/ADF self-selected food intake phase.

RESULTS

Dietary adherence remained high throughout the controlled food intake phase (days adherent: 86%) and the self-selected food intake phase (days adherent: 89%). The rate of weight loss remained constant during controlled food intake (0.67 +/- 0.1 kg/wk) and self-selected food intake phases (0.68 +/- 0.1 kg/wk). Body weight decreased (P < 0.001) by 5.6 +/- 1.0 kg (5.8 +/- 1.1%) after 8 wk of diet. Percentage body fat decreased (P < 0.01) from 45 +/- 2% to 42 +/- 2%. Total cholesterol, LDL cholesterol, and triacylglycerol concentrations decreased (P < 0.01) by 21 +/- 4%, 25 +/- 10%, and 32 +/- 6%, respectively, after 8 wk of ADF, whereas HDL cholesterol remained unchanged. Systolic blood pressure decreased (P < 0.05) from 124 +/- 5 to 116 +/- 3 mm Hg.

CONCLUSION

These findings suggest that ADF is a viable diet option to help obese individuals lose weight and decrease CAD risk. This trial was registered at clinicaltrials.gov as UIC-004-2009.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA. varady@uic.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19793855

Citation

Varady, Krista A., et al. "Short-term Modified Alternate-day Fasting: a Novel Dietary Strategy for Weight Loss and Cardioprotection in Obese Adults." The American Journal of Clinical Nutrition, vol. 90, no. 5, 2009, pp. 1138-43.
Varady KA, Bhutani S, Church EC, et al. Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. Am J Clin Nutr. 2009;90(5):1138-43.
Varady, K. A., Bhutani, S., Church, E. C., & Klempel, M. C. (2009). Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. The American Journal of Clinical Nutrition, 90(5), 1138-43. https://doi.org/10.3945/ajcn.2009.28380
Varady KA, et al. Short-term Modified Alternate-day Fasting: a Novel Dietary Strategy for Weight Loss and Cardioprotection in Obese Adults. Am J Clin Nutr. 2009;90(5):1138-43. PubMed PMID: 19793855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. AU - Varady,Krista A, AU - Bhutani,Surabhi, AU - Church,Emily C, AU - Klempel,Monica C, Y1 - 2009/09/30/ PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2010/1/7/medline SP - 1138 EP - 43 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 90 IS - 5 N2 - BACKGROUND: The ability of modified alternate-day fasting (ADF; ie, consuming 25% of energy needs on the fast day and ad libitum food intake on the following day) to facilitate weight loss and lower vascular disease risk in obese individuals remains unknown. OBJECTIVE: This study examined the effects of ADF that is administered under controlled compared with self-implemented conditions on body weight and coronary artery disease (CAD) risk indicators in obese adults. DESIGN: Sixteen obese subjects (12 women, 4 men) completed a 10-wk trial, which consisted of 3 phases: 1) a 2-wk control phase, 2) a 4-wk weight loss/ADF controlled food intake phase, and 3) a 4-wk weight loss/ADF self-selected food intake phase. RESULTS: Dietary adherence remained high throughout the controlled food intake phase (days adherent: 86%) and the self-selected food intake phase (days adherent: 89%). The rate of weight loss remained constant during controlled food intake (0.67 +/- 0.1 kg/wk) and self-selected food intake phases (0.68 +/- 0.1 kg/wk). Body weight decreased (P < 0.001) by 5.6 +/- 1.0 kg (5.8 +/- 1.1%) after 8 wk of diet. Percentage body fat decreased (P < 0.01) from 45 +/- 2% to 42 +/- 2%. Total cholesterol, LDL cholesterol, and triacylglycerol concentrations decreased (P < 0.01) by 21 +/- 4%, 25 +/- 10%, and 32 +/- 6%, respectively, after 8 wk of ADF, whereas HDL cholesterol remained unchanged. Systolic blood pressure decreased (P < 0.05) from 124 +/- 5 to 116 +/- 3 mm Hg. CONCLUSION: These findings suggest that ADF is a viable diet option to help obese individuals lose weight and decrease CAD risk. This trial was registered at clinicaltrials.gov as UIC-004-2009. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19793855/Short_term_modified_alternate_day_fasting:_a_novel_dietary_strategy_for_weight_loss_and_cardioprotection_in_obese_adults_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28380 DB - PRIME DP - Unbound Medicine ER -