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One-year weight maintenance after significant weight loss in healthy overweight and obese subjects: does diet composition matter?
Am J Clin Nutr. 2009 Nov; 90(5):1203-14.AJ

Abstract

BACKGROUND

For many people, maintenance of weight loss is elusive. Whereas high-protein (HP) diets have been found to be superior to high-carbohydrate (HC) diets for weight loss in the short term, their benefits long term are unclear, particularly for weight maintenance. Furthermore, the literature lacks consensus on the long-term effects of an HP diet on cardiovascular disease risk factors.

OBJECTIVE

The objective was to investigate whether macronutrient dietary composition plays a role in weight maintenance and in improvement of cardiovascular disease risk factors.

DESIGN

The study comprised 2 phases. Phase 1 featured a very-low-energy diet for 3 mo. In phase 2, the subjects were randomly assigned to an HP or an HC diet for 12 mo. The diets were isocaloric, tightly controlled, and individually prescribed for weight maintenance. The subjects were overweight or obese but otherwise healthy men and women.

RESULTS

The subjects lost an average of 16.5 kg during phase 1 and maintained a mean (+/-SEM) weight loss of 14.5 +/- 1.2 kg (P < 0.001) during phase 2; no significant differences between groups were observed. By the end of the study, reductions in systolic blood pressure were 14.3 +/- 2.4 mm Hg for the HP group and 7.7 +/- 2.2 mm Hg for the HC group (P < 0.045). Forty-seven percent of the 180 subjects who began the study completed both phases.

CONCLUSIONS

The results indicate that the protein or carbohydrate content of the diet has no effect on successful weight-loss maintenance. A general linear model analysis indicated that dietary treatment (HP or HC) was a significant factor in systolic blood pressure change and in favor of the HP diet. This trial was registered at www.clinicaltrials.gov as NCT 00625236.

Authors+Show Affiliations

Department of Medicine, Heidelberg Repatriation Hospital, Heidelberg, Australia. l.delbridge@unimelb.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19793858

Citation

Delbridge, Elizabeth A., et al. "One-year Weight Maintenance After Significant Weight Loss in Healthy Overweight and Obese Subjects: Does Diet Composition Matter?" The American Journal of Clinical Nutrition, vol. 90, no. 5, 2009, pp. 1203-14.
Delbridge EA, Prendergast LA, Pritchard JE, et al. One-year weight maintenance after significant weight loss in healthy overweight and obese subjects: does diet composition matter? Am J Clin Nutr. 2009;90(5):1203-14.
Delbridge, E. A., Prendergast, L. A., Pritchard, J. E., & Proietto, J. (2009). One-year weight maintenance after significant weight loss in healthy overweight and obese subjects: does diet composition matter? The American Journal of Clinical Nutrition, 90(5), 1203-14. https://doi.org/10.3945/ajcn.2008.27209
Delbridge EA, et al. One-year Weight Maintenance After Significant Weight Loss in Healthy Overweight and Obese Subjects: Does Diet Composition Matter. Am J Clin Nutr. 2009;90(5):1203-14. PubMed PMID: 19793858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One-year weight maintenance after significant weight loss in healthy overweight and obese subjects: does diet composition matter? AU - Delbridge,Elizabeth A, AU - Prendergast,Luke A, AU - Pritchard,Janet E, AU - Proietto,Joseph, Y1 - 2009/09/30/ PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2010/1/7/medline SP - 1203 EP - 14 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 5 N2 - BACKGROUND: For many people, maintenance of weight loss is elusive. Whereas high-protein (HP) diets have been found to be superior to high-carbohydrate (HC) diets for weight loss in the short term, their benefits long term are unclear, particularly for weight maintenance. Furthermore, the literature lacks consensus on the long-term effects of an HP diet on cardiovascular disease risk factors. OBJECTIVE: The objective was to investigate whether macronutrient dietary composition plays a role in weight maintenance and in improvement of cardiovascular disease risk factors. DESIGN: The study comprised 2 phases. Phase 1 featured a very-low-energy diet for 3 mo. In phase 2, the subjects were randomly assigned to an HP or an HC diet for 12 mo. The diets were isocaloric, tightly controlled, and individually prescribed for weight maintenance. The subjects were overweight or obese but otherwise healthy men and women. RESULTS: The subjects lost an average of 16.5 kg during phase 1 and maintained a mean (+/-SEM) weight loss of 14.5 +/- 1.2 kg (P < 0.001) during phase 2; no significant differences between groups were observed. By the end of the study, reductions in systolic blood pressure were 14.3 +/- 2.4 mm Hg for the HP group and 7.7 +/- 2.2 mm Hg for the HC group (P < 0.045). Forty-seven percent of the 180 subjects who began the study completed both phases. CONCLUSIONS: The results indicate that the protein or carbohydrate content of the diet has no effect on successful weight-loss maintenance. A general linear model analysis indicated that dietary treatment (HP or HC) was a significant factor in systolic blood pressure change and in favor of the HP diet. This trial was registered at www.clinicaltrials.gov as NCT 00625236. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19793858/One_year_weight_maintenance_after_significant_weight_loss_in_healthy_overweight_and_obese_subjects:_does_diet_composition_matter L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.27209 DB - PRIME DP - Unbound Medicine ER -