Tags

Type your tag names separated by a space and hit enter

Association of vitamin D deficiency with cognitive impairment in older women: cross-sectional study.
Neurology 2010; 74(1):27-32Neur

Abstract

OBJECTIVE

The association between low serum 25-hydroxyvitamin D [25(OH)D] concentration and cognitive decline has been investigated by only a few studies, with mixed results. The objective of this cross-sectional population-based study was to examine the association between serum 25(OH)D deficiency and cognitive impairment while taking confounders into account.

METHODS

The subjects, 752 women aged > or =75 years from the Epidémiologie de l'Ostéoporose (EPIDOS) cohort, were divided into 2 groups according to serum 25(OH)D concentrations (either deficient, <10 ng/mL, or nondeficient, > or =10 ng/mL). Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, number of chronic diseases, hypertension, depression, use of psychoactive drugs, education level, regular physical activity, and serum intact parathyroid hormone and calcium were used as potential confounders.

RESULTS

Compared with women with serum 25(OH)D concentrations > or =10 ng/mL (n = 623), the women with 25(OH)D deficiency (n = 129) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.006). There was no significant linear association between serum 25(OH)D concentration and SPMSQ score (beta = -0.003, 95% confidence interval -0.012 to 0.006, p = 0.512). However, serum 25(OH)D deficiency was associated with cognitive impairment (crude odds ratio [OR] = 2.08 with p = 0.007; adjusted OR = 1.99 with p = 0.017 for full model; and adjusted OR = 2.03 with p = 0.012 for stepwise backward model).

CONCLUSIONS

25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.

Authors+Show Affiliations

Department of Internal Medicine and Geriatrics, Angers University Hospital, 49933 Angers Cedex 9, France. ceannweiler@chu-angers.fr

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19794127

Citation

Annweiler, C, et al. "Association of Vitamin D Deficiency With Cognitive Impairment in Older Women: Cross-sectional Study." Neurology, vol. 74, no. 1, 2010, pp. 27-32.
Annweiler C, Schott AM, Allali G, et al. Association of vitamin D deficiency with cognitive impairment in older women: cross-sectional study. Neurology. 2010;74(1):27-32.
Annweiler, C., Schott, A. M., Allali, G., Bridenbaugh, S. A., Kressig, R. W., Allain, P., ... Beauchet, O. (2010). Association of vitamin D deficiency with cognitive impairment in older women: cross-sectional study. Neurology, 74(1), pp. 27-32. doi:10.1212/WNL.0b013e3181beecd3.
Annweiler C, et al. Association of Vitamin D Deficiency With Cognitive Impairment in Older Women: Cross-sectional Study. Neurology. 2010 Jan 5;74(1):27-32. PubMed PMID: 19794127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of vitamin D deficiency with cognitive impairment in older women: cross-sectional study. AU - Annweiler,C, AU - Schott,A M, AU - Allali,G, AU - Bridenbaugh,S A, AU - Kressig,R W, AU - Allain,P, AU - Herrmann,F R, AU - Beauchet,O, Y1 - 2009/09/30/ PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2010/1/16/medline SP - 27 EP - 32 JF - Neurology JO - Neurology VL - 74 IS - 1 N2 - OBJECTIVE: The association between low serum 25-hydroxyvitamin D [25(OH)D] concentration and cognitive decline has been investigated by only a few studies, with mixed results. The objective of this cross-sectional population-based study was to examine the association between serum 25(OH)D deficiency and cognitive impairment while taking confounders into account. METHODS: The subjects, 752 women aged > or =75 years from the Epidémiologie de l'Ostéoporose (EPIDOS) cohort, were divided into 2 groups according to serum 25(OH)D concentrations (either deficient, <10 ng/mL, or nondeficient, > or =10 ng/mL). Cognitive impairment was defined as a Pfeiffer Short Portable Mental State Questionnaire (SPMSQ) score <8. Age, body mass index, number of chronic diseases, hypertension, depression, use of psychoactive drugs, education level, regular physical activity, and serum intact parathyroid hormone and calcium were used as potential confounders. RESULTS: Compared with women with serum 25(OH)D concentrations > or =10 ng/mL (n = 623), the women with 25(OH)D deficiency (n = 129) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.006). There was no significant linear association between serum 25(OH)D concentration and SPMSQ score (beta = -0.003, 95% confidence interval -0.012 to 0.006, p = 0.512). However, serum 25(OH)D deficiency was associated with cognitive impairment (crude odds ratio [OR] = 2.08 with p = 0.007; adjusted OR = 1.99 with p = 0.017 for full model; and adjusted OR = 2.03 with p = 0.012 for stepwise backward model). CONCLUSIONS: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/19794127/Association_of_vitamin_D_deficiency_with_cognitive_impairment_in_older_women:_cross_sectional_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=19794127 DB - PRIME DP - Unbound Medicine ER -