Prime

Type your tag names separated by a space and hit enter

Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring.

Abstract

BACKGROUND

Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology.

AIMS

To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring psychotic symptoms.

METHOD

A longitudinal study of 6356 adolescents, age 12, who completed a semi-structured interview for psychotic symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.

RESULTS

Frequency of maternal tobacco use during pregnancy was associated with increased risk of suspected or definite psychotic symptoms (adjusted odds ratio 1.20, 95% CI 1.05-1.37, P = 0.007). Maternal alcohol use showed a non-linear association with psychotic symptoms, with this effect almost exclusively in the offspring of women drinking >21 units weekly. Maternal cannabis use was not associated with psychotic symptoms. Results for paternal smoking during pregnancy and maternal smoking post-pregnancy lend some support for a causal effect of tobacco exposure in utero on development of psychotic experiences.

CONCLUSIONS

These findings indicate that risk factors for development of non-clinical psychotic experiences may operate during early development. Future studies of how in utero exposure to tobacco affects cerebral development and function may lead to increased understanding of the pathogenesis of psychotic phenomena.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK. zammits@Cardiff.ac.uk

    , , , , , , , ,

    Source

    MeSH

    Adolescent
    Alcohol Drinking
    Cannabis
    Child
    Dose-Response Relationship, Drug
    Epidemiologic Methods
    Female
    Humans
    Male
    Marijuana Abuse
    Maternal Exposure
    Pregnancy
    Pregnancy Trimesters
    Prenatal Exposure Delayed Effects
    Psychotic Disorders
    Smoking

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19794196

    Citation

    TY - JOUR T1 - Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring. AU - Zammit,Stanley, AU - Thomas,Kate, AU - Thompson,Andrew, AU - Horwood,Jeremy, AU - Menezes,Paulo, AU - Gunnell,David, AU - Hollis,Chris, AU - Wolke,Dieter, AU - Lewis,Glyn, AU - Harrison,Glynn, PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2009/12/17/medline SP - 294 EP - 300 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 195 IS - 4 N2 - BACKGROUND: Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology. AIMS: To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring psychotic symptoms. METHOD: A longitudinal study of 6356 adolescents, age 12, who completed a semi-structured interview for psychotic symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. RESULTS: Frequency of maternal tobacco use during pregnancy was associated with increased risk of suspected or definite psychotic symptoms (adjusted odds ratio 1.20, 95% CI 1.05-1.37, P = 0.007). Maternal alcohol use showed a non-linear association with psychotic symptoms, with this effect almost exclusively in the offspring of women drinking >21 units weekly. Maternal cannabis use was not associated with psychotic symptoms. Results for paternal smoking during pregnancy and maternal smoking post-pregnancy lend some support for a causal effect of tobacco exposure in utero on development of psychotic experiences. CONCLUSIONS: These findings indicate that risk factors for development of non-clinical psychotic experiences may operate during early development. Future studies of how in utero exposure to tobacco affects cerebral development and function may lead to increased understanding of the pathogenesis of psychotic phenomena. SN - 1472-1465 UR - https://www.unboundmedicine.com/medline/citation/19794196/abstract/Maternal_tobacco_cannabis_and_alcohol_use_during_pregnancy_and_risk_of_adolescent_psychotic_symptoms_in_offspring_ L2 - https://www.cambridge.org/core/product/identifier/S0007125000250484/type/journal_article ER -