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Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis.

Abstract

A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis. This locus is of special interest because the R92Q substitution was previously detected in a group of multiple sclerosis patients who had additional symptoms compatible with the autoinflammatory syndrome TRAPS.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Clinical Neuroimmunology-Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, Munich, Germany. tania.kuempfel@med.uni-muenchen.de

    Source

    Nature reviews. Neurology 5:10 2009 Oct pg 528-9

    MeSH

    Autoimmune Diseases
    Genetic Predisposition to Disease
    Genome-Wide Association Study
    Humans
    Multiple Sclerosis
    Receptors, Tumor Necrosis Factor
    Receptors, Tumor Necrosis Factor, Type I
    Signal Transduction
    Syndrome
    Tumor Necrosis Factor-alpha

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19794511

    Citation

    Kümpfel, Tania, and Reinhard Hohlfeld. "Multiple Sclerosis. TNFRSF1A, TRAPS and Multiple Sclerosis." Nature Reviews. Neurology, vol. 5, no. 10, 2009, pp. 528-9.
    Kümpfel T, Hohlfeld R. Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis. Nat Rev Neurol. 2009;5(10):528-9.
    Kümpfel, T., & Hohlfeld, R. (2009). Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis. Nature Reviews. Neurology, 5(10), pp. 528-9. doi:10.1038/nrneurol.2009.154.
    Kümpfel T, Hohlfeld R. Multiple Sclerosis. TNFRSF1A, TRAPS and Multiple Sclerosis. Nat Rev Neurol. 2009;5(10):528-9. PubMed PMID: 19794511.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis. AU - Kümpfel,Tania, AU - Hohlfeld,Reinhard, PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2009/12/17/medline SP - 528 EP - 9 JF - Nature reviews. Neurology JO - Nat Rev Neurol VL - 5 IS - 10 N2 - A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis. This locus is of special interest because the R92Q substitution was previously detected in a group of multiple sclerosis patients who had additional symptoms compatible with the autoinflammatory syndrome TRAPS. SN - 1759-4766 UR - https://www.unboundmedicine.com/medline/citation/19794511/Multiple_sclerosis__TNFRSF1A_TRAPS_and_multiple_sclerosis_ L2 - http://dx.doi.org/10.1038/nrneurol.2009.154 DB - PRIME DP - Unbound Medicine ER -