Tags

Type your tag names separated by a space and hit enter

The effects of intravenous ephedrine during spinal anesthesia for cesarean delivery: a randomized controlled trial.
J Korean Med Sci. 2009 Oct; 24(5):883-8.JK

Abstract

We designed a randomized, double-blinded study to determine the efficacy and safety of 0.5 mg/kg intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Patients were randomly allocated into two groups: ephedrine group (n=21) and control group (n=21). Intravenous preload of 15 mL/kg lactated Ringer's solution was given. Shortly after the spinal injection, ephedrine 0.5 mg/kg or saline was injected intravenous for 60 sec. The mean of highest and lowest heart rate in the ephedrine group was higher than those of control group (P<0.05). There were significant lower incidences of hypotension and nausea and vomiting in the ephedrine group compared with the control group (8 [38.1%] vs. 18 [85.7%]); (4 [19%] vs. 12 [57.1%], respectively) (P<0.05). The first rescue ephedrine time in the ephedrine group was significantly longer (14.9+/-7.1 min vs. 7.9+/-5.4 min) than that of the control group (P<0.05). Neonatal outcome were similar between the study groups. These findings suggest, the prophylactic bolus dose of 0.5 mg/kg intravenous ephedrine given at the time of intrathecal block after a crystalloid fluid preload, plus rescue boluses reduce the incidence of hypotension.

Authors+Show Affiliations

Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey. driclal@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19794988

Citation

Kol, Iclal Ozdemir, et al. "The Effects of Intravenous Ephedrine During Spinal Anesthesia for Cesarean Delivery: a Randomized Controlled Trial." Journal of Korean Medical Science, vol. 24, no. 5, 2009, pp. 883-8.
Kol IO, Kaygusuz K, Gursoy S, et al. The effects of intravenous ephedrine during spinal anesthesia for cesarean delivery: a randomized controlled trial. J Korean Med Sci. 2009;24(5):883-8.
Kol, I. O., Kaygusuz, K., Gursoy, S., Cetin, A., Kahramanoglu, Z., Ozkan, F., & Mimaroglu, C. (2009). The effects of intravenous ephedrine during spinal anesthesia for cesarean delivery: a randomized controlled trial. Journal of Korean Medical Science, 24(5), 883-8. https://doi.org/10.3346/jkms.2009.24.5.883
Kol IO, et al. The Effects of Intravenous Ephedrine During Spinal Anesthesia for Cesarean Delivery: a Randomized Controlled Trial. J Korean Med Sci. 2009;24(5):883-8. PubMed PMID: 19794988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of intravenous ephedrine during spinal anesthesia for cesarean delivery: a randomized controlled trial. AU - Kol,Iclal Ozdemir, AU - Kaygusuz,Kenan, AU - Gursoy,Sinan, AU - Cetin,Ali, AU - Kahramanoglu,Zeki, AU - Ozkan,Fikret, AU - Mimaroglu,Caner, Y1 - 2009/09/23/ PY - 2008/03/26/received PY - 2008/11/11/accepted PY - 2009/10/2/entrez PY - 2009/10/2/pubmed PY - 2010/1/28/medline KW - Anesthesia, Spinal KW - Cesarean Section KW - Ephedrine KW - Hypotension SP - 883 EP - 8 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 24 IS - 5 N2 - We designed a randomized, double-blinded study to determine the efficacy and safety of 0.5 mg/kg intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Patients were randomly allocated into two groups: ephedrine group (n=21) and control group (n=21). Intravenous preload of 15 mL/kg lactated Ringer's solution was given. Shortly after the spinal injection, ephedrine 0.5 mg/kg or saline was injected intravenous for 60 sec. The mean of highest and lowest heart rate in the ephedrine group was higher than those of control group (P<0.05). There were significant lower incidences of hypotension and nausea and vomiting in the ephedrine group compared with the control group (8 [38.1%] vs. 18 [85.7%]); (4 [19%] vs. 12 [57.1%], respectively) (P<0.05). The first rescue ephedrine time in the ephedrine group was significantly longer (14.9+/-7.1 min vs. 7.9+/-5.4 min) than that of the control group (P<0.05). Neonatal outcome were similar between the study groups. These findings suggest, the prophylactic bolus dose of 0.5 mg/kg intravenous ephedrine given at the time of intrathecal block after a crystalloid fluid preload, plus rescue boluses reduce the incidence of hypotension. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/19794988/The_effects_of_intravenous_ephedrine_during_spinal_anesthesia_for_cesarean_delivery:_a_randomized_controlled_trial_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2009.24.5.883 DB - PRIME DP - Unbound Medicine ER -