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[Alcaligenes xylosoxidans bacteremia in a patient with acute lymphoblastic leukemia].
Mikrobiyol Bul. 2009 Jul; 43(3):481-5.MB

Abstract

Alcaligenes xylosoxidans which is an aerobic, non-fermentative gram-negative bacillus found in aqueous environments and human flora, can lead to opportunistic infections. It causes infections in elderly, immunocompromised patients, patients with chronic disorders or premature infants. In this report, a case of A. xylosoxidans bacteremia that developed in a child with acute lymphoblastic leukemia (ALL) was presented. Four-years-old male patient under ALL induction therapy was admitted with symptoms of lethargy, headache, somnolence, and fever (39 degrees C). Cerebrospinal fluid, blood, throat and urine cultures were taken from the patient and empirical treatment with sulbactam cefoperazon and amikacin was initiated. Blood cultures in BacT Alert 3D (Bio Merieux, France) revealed the growth of a gram-negative coccobacillus. The agent which was non-fermentative, indol and H2S negative, was identified as A. xylosoxidans by API 20 NE (Bio Merieux, France). Since fever continued under the current antibiotic treatment, the therapy was switched to imipenem (90 mg/kg 3x/day) and the patient's condition improved markedly after 24 hours. Disc diffusion susceptibility testing of the isolate revealed that it was resistant to ampicillin, cephalothin, cefuroxime, cefoxitin, cefotaxime, amikacin, netilmicin and gentamicin; susceptible to amoxicillin clavulanate, piperacillin tazobactam, seftazidime, cefepime, imipenem and ciprofloxacin. Following 14 days of imipenem therapy, the patient recovered and discharged from the hospital on routine follow-up. It is important to consider A. xylosoxidans as a possible causative agent particularly in the infections that develop in high risk patients at oncology, dialysis and neonatal intensive care units.

Authors+Show Affiliations

Istanbul Universitesi Cerrahpaşa Tip Fakültesi, Pediatrik Hematoloji-Onkoloji Bilim Dali, Istanbul.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

tur

PubMed ID

19795625

Citation

Aydemir, Zeynep Alp, et al. "[Alcaligenes Xylosoxidans Bacteremia in a Patient With Acute Lymphoblastic Leukemia]." Mikrobiyoloji Bulteni, vol. 43, no. 3, 2009, pp. 481-5.
Aydemir ZA, Ozdemir N, Celik N, et al. [Alcaligenes xylosoxidans bacteremia in a patient with acute lymphoblastic leukemia]. Mikrobiyol Bul. 2009;43(3):481-5.
Aydemir, Z. A., Ozdemir, N., Celik, N., & Celkan, T. (2009). [Alcaligenes xylosoxidans bacteremia in a patient with acute lymphoblastic leukemia]. Mikrobiyoloji Bulteni, 43(3), 481-5.
Aydemir ZA, et al. [Alcaligenes Xylosoxidans Bacteremia in a Patient With Acute Lymphoblastic Leukemia]. Mikrobiyol Bul. 2009;43(3):481-5. PubMed PMID: 19795625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Alcaligenes xylosoxidans bacteremia in a patient with acute lymphoblastic leukemia]. AU - Aydemir,Zeynep Alp, AU - Ozdemir,Nihal, AU - Celik,Nigar, AU - Celkan,Tiraje, PY - 2009/10/3/entrez PY - 2009/10/3/pubmed PY - 2010/6/9/medline SP - 481 EP - 5 JF - Mikrobiyoloji bulteni JO - Mikrobiyol Bul VL - 43 IS - 3 N2 - Alcaligenes xylosoxidans which is an aerobic, non-fermentative gram-negative bacillus found in aqueous environments and human flora, can lead to opportunistic infections. It causes infections in elderly, immunocompromised patients, patients with chronic disorders or premature infants. In this report, a case of A. xylosoxidans bacteremia that developed in a child with acute lymphoblastic leukemia (ALL) was presented. Four-years-old male patient under ALL induction therapy was admitted with symptoms of lethargy, headache, somnolence, and fever (39 degrees C). Cerebrospinal fluid, blood, throat and urine cultures were taken from the patient and empirical treatment with sulbactam cefoperazon and amikacin was initiated. Blood cultures in BacT Alert 3D (Bio Merieux, France) revealed the growth of a gram-negative coccobacillus. The agent which was non-fermentative, indol and H2S negative, was identified as A. xylosoxidans by API 20 NE (Bio Merieux, France). Since fever continued under the current antibiotic treatment, the therapy was switched to imipenem (90 mg/kg 3x/day) and the patient's condition improved markedly after 24 hours. Disc diffusion susceptibility testing of the isolate revealed that it was resistant to ampicillin, cephalothin, cefuroxime, cefoxitin, cefotaxime, amikacin, netilmicin and gentamicin; susceptible to amoxicillin clavulanate, piperacillin tazobactam, seftazidime, cefepime, imipenem and ciprofloxacin. Following 14 days of imipenem therapy, the patient recovered and discharged from the hospital on routine follow-up. It is important to consider A. xylosoxidans as a possible causative agent particularly in the infections that develop in high risk patients at oncology, dialysis and neonatal intensive care units. SN - 0374-9096 UR - https://www.unboundmedicine.com/medline/citation/19795625/[Alcaligenes_xylosoxidans_bacteremia_in_a_patient_with_acute_lymphoblastic_leukemia]_ L2 - http://www.diseaseinfosearch.org/result/188 DB - PRIME DP - Unbound Medicine ER -