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Mesenchymal stromal cells.
Ann N Y Acad Sci. 2009 Sep; 1176:101-17.AN

Abstract

Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype, and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and in humans, although the exact mechanisms underlying these effects remain largely unknown. MSCs preferentially home to damaged tissue and secrete paracrine factors with anti-inflammatory properties. The immunomodulatory and reparative and anti-inflammatory properties of MSCs have been tested in a variety of animal models and have been applied in specific clinical settings. Potential clinical applications of MSCs include prevention and treatment of therapy-resistant acute graft-versus-host disease, prevention and treatment of rejection after either hematopoieitc stem cell and solid organ transplantation, tissue repair, and treatment of inborn errors and autoimmune diseases. This review focuses on recent advances that have broadened our understanding of the biological and functional properties of MSCs, which are increasingly attracting the attention of researchers involved in the optimization of approaches for reparative and regenerative cell therapy, as well as in the perspective of modulating immune response against alloantigens or, even, autoantigens.

Authors+Show Affiliations

Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Università di Pavia, Pavia, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19796238

Citation

Bernardo, Maria Ester, et al. "Mesenchymal Stromal Cells." Annals of the New York Academy of Sciences, vol. 1176, 2009, pp. 101-17.
Bernardo ME, Locatelli F, Fibbe WE. Mesenchymal stromal cells. Ann N Y Acad Sci. 2009;1176:101-17.
Bernardo, M. E., Locatelli, F., & Fibbe, W. E. (2009). Mesenchymal stromal cells. Annals of the New York Academy of Sciences, 1176, 101-17. https://doi.org/10.1111/j.1749-6632.2009.04607.x
Bernardo ME, Locatelli F, Fibbe WE. Mesenchymal Stromal Cells. Ann N Y Acad Sci. 2009;1176:101-17. PubMed PMID: 19796238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal stromal cells. AU - Bernardo,Maria Ester, AU - Locatelli,Franco, AU - Fibbe,Willem E, PY - 2009/10/3/entrez PY - 2009/10/3/pubmed PY - 2009/10/24/medline SP - 101 EP - 17 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1176 N2 - Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype, and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and in humans, although the exact mechanisms underlying these effects remain largely unknown. MSCs preferentially home to damaged tissue and secrete paracrine factors with anti-inflammatory properties. The immunomodulatory and reparative and anti-inflammatory properties of MSCs have been tested in a variety of animal models and have been applied in specific clinical settings. Potential clinical applications of MSCs include prevention and treatment of therapy-resistant acute graft-versus-host disease, prevention and treatment of rejection after either hematopoieitc stem cell and solid organ transplantation, tissue repair, and treatment of inborn errors and autoimmune diseases. This review focuses on recent advances that have broadened our understanding of the biological and functional properties of MSCs, which are increasingly attracting the attention of researchers involved in the optimization of approaches for reparative and regenerative cell therapy, as well as in the perspective of modulating immune response against alloantigens or, even, autoantigens. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/19796238/Mesenchymal_stromal_cells_ L2 - https://doi.org/10.1111/j.1749-6632.2009.04607.x DB - PRIME DP - Unbound Medicine ER -