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The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber.
Am J Ophthalmol. 2009 Dec; 148(6):902-9.AJ

Abstract

PURPOSE

To assess the association of total serum levels of homocysteine (tHcy), folate, and vitamin B12 with retinal vascular caliber in older adults.

DESIGN

Cross-sectional, population-based study.

METHODS

One thousand seven hundred and seventy-two of 2334 Blue Mountains Eye Study participants examined had fundus photographs taken and retinal arteriolar and venular caliber measured using computer-assisted techniques and summarized. Serum folate and vitamin B12 levels and tHcy were determined from venous blood samples. Linear regression models adjusting for age, gender, mean arterial blood pressure, smoking, and diabetes were used to assess whether serum levels of tHcy, folate, and vitamin B12 were associated with retinal arteriolar and venular caliber.

RESULTS

Arteriolar and venular caliber was not associated with tHcy in the total population. Further analysis demonstrated a significant serum homocysteine-gender interaction (P = .04). A significant inverse association between tHcy and arteriolar caliber was found in men only (P = .03), with a threshold detected at a level of 17 micromol/l. Above this threshold, increasing tHcy was linearly associated with narrower arteriolar caliber (0.86 microm reduction per 1.0 micromol/l increase in tHcy) in men, but no significant association was found below this threshold. No significant associations were observed between serum folate or vitamin B12 levels and either retinal vessel caliber.

CONCLUSIONS

Retinal vascular caliber is associated with tHcy in men but not women. This finding may reflect the stronger association between blood pressure and tHcy in men than in women.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19796756

Citation

Gopinath, Bamini, et al. "The Associations Between Blood Levels of Homocysteine, Folate, Vitamin B12, and Retinal Vascular Caliber." American Journal of Ophthalmology, vol. 148, no. 6, 2009, pp. 902-9.
Gopinath B, Wang JJ, Flood VM, et al. The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber. Am J Ophthalmol. 2009;148(6):902-9.
Gopinath, B., Wang, J. J., Flood, V. M., Burlutsky, G., Wong, T. Y., & Mitchell, P. (2009). The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber. American Journal of Ophthalmology, 148(6), 902-9. https://doi.org/10.1016/j.ajo.2009.07.018
Gopinath B, et al. The Associations Between Blood Levels of Homocysteine, Folate, Vitamin B12, and Retinal Vascular Caliber. Am J Ophthalmol. 2009;148(6):902-9. PubMed PMID: 19796756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber. AU - Gopinath,Bamini, AU - Wang,Jie Jin, AU - Flood,Victoria M, AU - Burlutsky,George, AU - Wong,Tien Y, AU - Mitchell,Paul, Y1 - 2009/10/01/ PY - 2009/04/28/received PY - 2009/06/30/revised PY - 2009/07/16/accepted PY - 2009/10/3/entrez PY - 2009/10/3/pubmed PY - 2009/12/16/medline SP - 902 EP - 9 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 148 IS - 6 N2 - PURPOSE: To assess the association of total serum levels of homocysteine (tHcy), folate, and vitamin B12 with retinal vascular caliber in older adults. DESIGN: Cross-sectional, population-based study. METHODS: One thousand seven hundred and seventy-two of 2334 Blue Mountains Eye Study participants examined had fundus photographs taken and retinal arteriolar and venular caliber measured using computer-assisted techniques and summarized. Serum folate and vitamin B12 levels and tHcy were determined from venous blood samples. Linear regression models adjusting for age, gender, mean arterial blood pressure, smoking, and diabetes were used to assess whether serum levels of tHcy, folate, and vitamin B12 were associated with retinal arteriolar and venular caliber. RESULTS: Arteriolar and venular caliber was not associated with tHcy in the total population. Further analysis demonstrated a significant serum homocysteine-gender interaction (P = .04). A significant inverse association between tHcy and arteriolar caliber was found in men only (P = .03), with a threshold detected at a level of 17 micromol/l. Above this threshold, increasing tHcy was linearly associated with narrower arteriolar caliber (0.86 microm reduction per 1.0 micromol/l increase in tHcy) in men, but no significant association was found below this threshold. No significant associations were observed between serum folate or vitamin B12 levels and either retinal vessel caliber. CONCLUSIONS: Retinal vascular caliber is associated with tHcy in men but not women. This finding may reflect the stronger association between blood pressure and tHcy in men than in women. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/19796756/The_associations_between_blood_levels_of_homocysteine_folate_vitamin_B12_and_retinal_vascular_caliber_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(09)00516-9 DB - PRIME DP - Unbound Medicine ER -