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Association between Gc genotype and susceptibility to TB is dependent on vitamin D status.
Eur Respir J. 2010 May; 35(5):1106-12.ER

Abstract

Group-specific component (Gc) variants of vitamin D binding protein differ in their affinity for vitamin D metabolites that modulate antimycobacterial immunity. We conducted studies to determine whether Gc genotype associates with susceptibility to tuberculosis (TB). The following subjects were recruited into case-control studies: in the UK, 123 adult TB patients and 140 controls, all of Gujarati Asian ethnic origin; in Brazil, 130 adult TB patients and 78 controls; and in South Africa, 281 children with TB and 182 controls. Gc genotypes were determined and their frequency was compared between cases versus controls. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were obtained retrospectively for 139 Gujarati Asians, and case-control analysis was stratified by vitamin D status. Interferon (IFN)-gamma release assays were also performed on 36 Gujarati Asian TB contacts. The Gc2/2 genotype was strongly associated with susceptibility to active TB in Gujarati Asians, compared with Gc1/1 genotype (OR 2.81, 95% CI 1.19-6.66; p = 0.009). This association was preserved if serum 25(OH)D was <20 nmol.L(-1) (p = 0.01) but not if serum 25(OH)D was > or =20 nmol.L(-1) (p = 0.36). Carriage of the Gc2 allele was associated with increased PPD of tuberculin-stimulated IFN-gamma release in Gujarati Asian TB contacts (p = 0.02). No association between Gc genotype and susceptibility to TB was observed in other ethnic groups studied.

Authors+Show Affiliations

Wellcome Trust Centre for Research in Clinical Tropical Medicine, Division of Medicine, Imperial College London, London, UK. a.martineau@qmul.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19797128

Citation

Martineau, A R., et al. "Association Between Gc Genotype and Susceptibility to TB Is Dependent On Vitamin D Status." The European Respiratory Journal, vol. 35, no. 5, 2010, pp. 1106-12.
Martineau AR, Leandro AC, Anderson ST, et al. Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. Eur Respir J. 2010;35(5):1106-12.
Martineau, A. R., Leandro, A. C., Anderson, S. T., Newton, S. M., Wilkinson, K. A., Nicol, M. P., Pienaar, S. M., Skolimowska, K. H., Rocha, M. A., Rolla, V. C., Levin, M., Davidson, R. N., Bremner, S. A., Griffiths, C. J., Eley, B. S., Bonecini-Almeida, M. G., & Wilkinson, R. J. (2010). Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. The European Respiratory Journal, 35(5), 1106-12. https://doi.org/10.1183/09031936.00087009
Martineau AR, et al. Association Between Gc Genotype and Susceptibility to TB Is Dependent On Vitamin D Status. Eur Respir J. 2010;35(5):1106-12. PubMed PMID: 19797128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. AU - Martineau,A R, AU - Leandro,A C C S, AU - Anderson,S T, AU - Newton,S M, AU - Wilkinson,K A, AU - Nicol,M P, AU - Pienaar,S M, AU - Skolimowska,K H, AU - Rocha,M A, AU - Rolla,V C, AU - Levin,M, AU - Davidson,R N, AU - Bremner,S A, AU - Griffiths,C J, AU - Eley,B S, AU - Bonecini-Almeida,M G, AU - Wilkinson,R J, Y1 - 2009/09/24/ PY - 2009/10/3/entrez PY - 2009/10/3/pubmed PY - 2010/8/14/medline SP - 1106 EP - 12 JF - The European respiratory journal JO - Eur. Respir. J. VL - 35 IS - 5 N2 - Group-specific component (Gc) variants of vitamin D binding protein differ in their affinity for vitamin D metabolites that modulate antimycobacterial immunity. We conducted studies to determine whether Gc genotype associates with susceptibility to tuberculosis (TB). The following subjects were recruited into case-control studies: in the UK, 123 adult TB patients and 140 controls, all of Gujarati Asian ethnic origin; in Brazil, 130 adult TB patients and 78 controls; and in South Africa, 281 children with TB and 182 controls. Gc genotypes were determined and their frequency was compared between cases versus controls. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were obtained retrospectively for 139 Gujarati Asians, and case-control analysis was stratified by vitamin D status. Interferon (IFN)-gamma release assays were also performed on 36 Gujarati Asian TB contacts. The Gc2/2 genotype was strongly associated with susceptibility to active TB in Gujarati Asians, compared with Gc1/1 genotype (OR 2.81, 95% CI 1.19-6.66; p = 0.009). This association was preserved if serum 25(OH)D was <20 nmol.L(-1) (p = 0.01) but not if serum 25(OH)D was > or =20 nmol.L(-1) (p = 0.36). Carriage of the Gc2 allele was associated with increased PPD of tuberculin-stimulated IFN-gamma release in Gujarati Asian TB contacts (p = 0.02). No association between Gc genotype and susceptibility to TB was observed in other ethnic groups studied. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/19797128/Association_between_Gc_genotype_and_susceptibility_to_TB_is_dependent_on_vitamin_D_status_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&amp;pmid=19797128 DB - PRIME DP - Unbound Medicine ER -