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Comparison of Cirrus OCT and Stratus OCT on the ability to detect localized retinal nerve fiber layer defects in preperimetric glaucoma.
Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):938-45.IO

Abstract

PURPOSE

To evaluate and compare the diagnostic ability of Cirrus and Stratus optical coherence tomography (OCT) to detect localized retinal nerve fiber layer (RNFL) defects in patients with normal standard automated perimetry.

METHODS

This study included 55 eyes of 55 subjects with preperimetric localized RNFL defects and 55 normal control eyes of 55 age- and sex-matched subjects. Areas under the receiver operating characteristic curves (AUROCs) were calculated and compared. Based on the internal normative database from each device, the sensitivity and specificity for detecting preperimetric localized RNFL defects were calculated.

RESULTS

There was no statistically significant difference between the AUROCs for the best parameters from the Cirrus OCT (inferior thickness, AUROC = 0.728) and Stratus OCT (7 o'clock sector, AUROC = 0.760; P = 0.477). The sensitivity of the Cirrus OCT parameters ranged from 21.0% to 87.1% and that of the Stratus OCT parameters ranged from 4.8% to 30.7%, with the criterion of abnormal at the 5% level. Based on the normative database, the highest Cirrus OCT sensitivity was obtained with the deviation-from-normal map (sensitivity 87.1% and specificity 61.8%), and the highest Stratus OCT sensitivity was obtained with the TSNIT thickness graph (sensitivity 30.7% and specificity 85.5%).

CONCLUSIONS

There were no significant differences between the AUROCs for Cirrus and Stratus OCT, indicating that the two devices have similar diagnostic potentials in preperimetric glaucoma. After comparison with their normative databases, Cirrus OCT had generally higher sensitivities; however, this was largely at the cost of lower specificities than Stratus OCT.

Authors+Show Affiliations

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19797208

Citation

Jeoung, Jin Wook, and Ki Ho Park. "Comparison of Cirrus OCT and Stratus OCT On the Ability to Detect Localized Retinal Nerve Fiber Layer Defects in Preperimetric Glaucoma." Investigative Ophthalmology & Visual Science, vol. 51, no. 2, 2010, pp. 938-45.
Jeoung JW, Park KH. Comparison of Cirrus OCT and Stratus OCT on the ability to detect localized retinal nerve fiber layer defects in preperimetric glaucoma. Invest Ophthalmol Vis Sci. 2010;51(2):938-45.
Jeoung, J. W., & Park, K. H. (2010). Comparison of Cirrus OCT and Stratus OCT on the ability to detect localized retinal nerve fiber layer defects in preperimetric glaucoma. Investigative Ophthalmology & Visual Science, 51(2), 938-45. https://doi.org/10.1167/iovs.08-3335
Jeoung JW, Park KH. Comparison of Cirrus OCT and Stratus OCT On the Ability to Detect Localized Retinal Nerve Fiber Layer Defects in Preperimetric Glaucoma. Invest Ophthalmol Vis Sci. 2010;51(2):938-45. PubMed PMID: 19797208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Cirrus OCT and Stratus OCT on the ability to detect localized retinal nerve fiber layer defects in preperimetric glaucoma. AU - Jeoung,Jin Wook, AU - Park,Ki Ho, Y1 - 2009/09/24/ PY - 2009/10/3/entrez PY - 2009/10/3/pubmed PY - 2010/2/18/medline SP - 938 EP - 45 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 51 IS - 2 N2 - PURPOSE: To evaluate and compare the diagnostic ability of Cirrus and Stratus optical coherence tomography (OCT) to detect localized retinal nerve fiber layer (RNFL) defects in patients with normal standard automated perimetry. METHODS: This study included 55 eyes of 55 subjects with preperimetric localized RNFL defects and 55 normal control eyes of 55 age- and sex-matched subjects. Areas under the receiver operating characteristic curves (AUROCs) were calculated and compared. Based on the internal normative database from each device, the sensitivity and specificity for detecting preperimetric localized RNFL defects were calculated. RESULTS: There was no statistically significant difference between the AUROCs for the best parameters from the Cirrus OCT (inferior thickness, AUROC = 0.728) and Stratus OCT (7 o'clock sector, AUROC = 0.760; P = 0.477). The sensitivity of the Cirrus OCT parameters ranged from 21.0% to 87.1% and that of the Stratus OCT parameters ranged from 4.8% to 30.7%, with the criterion of abnormal at the 5% level. Based on the normative database, the highest Cirrus OCT sensitivity was obtained with the deviation-from-normal map (sensitivity 87.1% and specificity 61.8%), and the highest Stratus OCT sensitivity was obtained with the TSNIT thickness graph (sensitivity 30.7% and specificity 85.5%). CONCLUSIONS: There were no significant differences between the AUROCs for Cirrus and Stratus OCT, indicating that the two devices have similar diagnostic potentials in preperimetric glaucoma. After comparison with their normative databases, Cirrus OCT had generally higher sensitivities; however, this was largely at the cost of lower specificities than Stratus OCT. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/19797208/Comparison_of_Cirrus_OCT_and_Stratus_OCT_on_the_ability_to_detect_localized_retinal_nerve_fiber_layer_defects_in_preperimetric_glaucoma_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.08-3335 DB - PRIME DP - Unbound Medicine ER -