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[Left ventricular myocardial hypertrophy after transplantation of the kidney: risk factors and possible regress].
Ter Arkh. 2009; 81(8):42-8.TA

Abstract

AIM

To study structural-functional changes in left ventricular (LV) myocardium in recipients of renal allograft (RA) after different postoperative period and to specify factors promoting persistence, progression or regression of LV hypertrophy (LVH).

MATERIAL AND METHODS

The study included 240 recipients of primary RA (38% females and 62% males, age 16-69 years, mean age 42 +/- 11 years). A prospective study covered 143 patients.

RESULTS

LVH was diagnosed in 52% patients. LVH incidence after renal transplantation (RT) had a wave-like dynamics: during 9 months after RT LVH presents in more than 50% patients; after 9-24 months after the operation it fell to 30% and after 3-7 years after the operation it affected at least 2/3 patients. After RT LVH risk factors were age, duration of chronic renal failure (CRF) and pretransplantation dialysis, reduced mass of the operating nephrons, arterial hypertension, anemia, functioning of arterio-venous fistula (AVF) and chronic inflammation syndrome. LVH was also associated with factors specific for RT: RA rejection crises, infections complicating massive immunosuppressive therapy. LVH is also associated with proteinuria which may indicate RA damage and can be considered as a marker of generalized endothelial dysfunction. 2-year and longer follow-up after RT confirmed complete LVH regression in 1/3 of the recipients. LVH regression was observed in normal RA function, normal blood pressure, the absence of proteinuria, hypoalbuminemia, anemia, AVF, infectious complications.

CONCLUSION

LVH after RT is multifactorial and can completely regress in a favourable posttransplantation course.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

19799199

Citation

Tomilina, N A., et al. "[Left Ventricular Myocardial Hypertrophy After Transplantation of the Kidney: Risk Factors and Possible Regress]." Terapevticheskii Arkhiv, vol. 81, no. 8, 2009, pp. 42-8.
Tomilina NA, Gendlin GE, Zhidkova DA, et al. [Left ventricular myocardial hypertrophy after transplantation of the kidney: risk factors and possible regress]. Ter Arkh. 2009;81(8):42-8.
Tomilina, N. A., Gendlin, G. E., Zhidkova, D. A., Tronina, O. A., & Fedorova, N. D. (2009). [Left ventricular myocardial hypertrophy after transplantation of the kidney: risk factors and possible regress]. Terapevticheskii Arkhiv, 81(8), 42-8.
Tomilina NA, et al. [Left Ventricular Myocardial Hypertrophy After Transplantation of the Kidney: Risk Factors and Possible Regress]. Ter Arkh. 2009;81(8):42-8. PubMed PMID: 19799199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Left ventricular myocardial hypertrophy after transplantation of the kidney: risk factors and possible regress]. AU - Tomilina,N A, AU - Gendlin,G E, AU - Zhidkova,D A, AU - Tronina,O A, AU - Fedorova,N D, PY - 2009/10/6/entrez PY - 2009/10/6/pubmed PY - 2010/2/25/medline SP - 42 EP - 8 JF - Terapevticheskii arkhiv JO - Ter Arkh VL - 81 IS - 8 N2 - AIM: To study structural-functional changes in left ventricular (LV) myocardium in recipients of renal allograft (RA) after different postoperative period and to specify factors promoting persistence, progression or regression of LV hypertrophy (LVH). MATERIAL AND METHODS: The study included 240 recipients of primary RA (38% females and 62% males, age 16-69 years, mean age 42 +/- 11 years). A prospective study covered 143 patients. RESULTS: LVH was diagnosed in 52% patients. LVH incidence after renal transplantation (RT) had a wave-like dynamics: during 9 months after RT LVH presents in more than 50% patients; after 9-24 months after the operation it fell to 30% and after 3-7 years after the operation it affected at least 2/3 patients. After RT LVH risk factors were age, duration of chronic renal failure (CRF) and pretransplantation dialysis, reduced mass of the operating nephrons, arterial hypertension, anemia, functioning of arterio-venous fistula (AVF) and chronic inflammation syndrome. LVH was also associated with factors specific for RT: RA rejection crises, infections complicating massive immunosuppressive therapy. LVH is also associated with proteinuria which may indicate RA damage and can be considered as a marker of generalized endothelial dysfunction. 2-year and longer follow-up after RT confirmed complete LVH regression in 1/3 of the recipients. LVH regression was observed in normal RA function, normal blood pressure, the absence of proteinuria, hypoalbuminemia, anemia, AVF, infectious complications. CONCLUSION: LVH after RT is multifactorial and can completely regress in a favourable posttransplantation course. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/19799199/[Left_ventricular_myocardial_hypertrophy_after_transplantation_of_the_kidney:_risk_factors_and_possible_regress]_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -