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Tumor characteristics and patient outcomes are similar between invasive lobular and mixed invasive ductal/lobular breast cancers but differ from pure invasive ductal breast cancers.
Am J Surg. 2009 Oct; 198(4):516-9.AJ

Abstract

BACKGROUND

The aim of this study was to investigate the clinical characteristics associated with invasive lobular cancer (ILC) and mixed invasive ductal cancer (IDC) and ILC compared with IDC.

METHODS

From 1996 to 2006, 4,336 patients with IDC, ILC, and mixed breast cancers were identified. Clinical variables were compared using chi(2) and Fisher's exact tests. Kaplan-Meier survival curves were constructed.

RESULTS

Patients included 3,595 (83%) with IDC, 480 (11%) with ILC, and 261 (6%) with mixed cancers. Patients with ILC and mixed cancers were more likely to have low-grade and estrogen-positive and progesterone-positive tumors but were diagnosed at higher stages of disease compared with patients with IDC (P < .05 for each). Patients with IDC had the poorest 5-year (80%) and 10-year (61%) survival compared with patients with ILC (87% and 68%) and mixed (84% and 69%) cancers (P = .029).

CONCLUSIONS

Although patients with ILC and "mixed" cancers are diagnosed with more advanced disease, their survival is superior to patients with IDC.

Authors+Show Affiliations

Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19800459

Citation

Bharat, Ankit, et al. "Tumor Characteristics and Patient Outcomes Are Similar Between Invasive Lobular and Mixed Invasive Ductal/lobular Breast Cancers but Differ From Pure Invasive Ductal Breast Cancers." American Journal of Surgery, vol. 198, no. 4, 2009, pp. 516-9.
Bharat A, Gao F, Margenthaler JA. Tumor characteristics and patient outcomes are similar between invasive lobular and mixed invasive ductal/lobular breast cancers but differ from pure invasive ductal breast cancers. Am J Surg. 2009;198(4):516-9.
Bharat, A., Gao, F., & Margenthaler, J. A. (2009). Tumor characteristics and patient outcomes are similar between invasive lobular and mixed invasive ductal/lobular breast cancers but differ from pure invasive ductal breast cancers. American Journal of Surgery, 198(4), 516-9. https://doi.org/10.1016/j.amjsurg.2009.06.005
Bharat A, Gao F, Margenthaler JA. Tumor Characteristics and Patient Outcomes Are Similar Between Invasive Lobular and Mixed Invasive Ductal/lobular Breast Cancers but Differ From Pure Invasive Ductal Breast Cancers. Am J Surg. 2009;198(4):516-9. PubMed PMID: 19800459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumor characteristics and patient outcomes are similar between invasive lobular and mixed invasive ductal/lobular breast cancers but differ from pure invasive ductal breast cancers. AU - Bharat,Ankit, AU - Gao,Feng, AU - Margenthaler,Julie A, PY - 2009/03/22/received PY - 2009/06/14/revised PY - 2009/06/14/accepted PY - 2009/10/6/entrez PY - 2009/10/6/pubmed PY - 2009/10/20/medline SP - 516 EP - 9 JF - American journal of surgery JO - Am. J. Surg. VL - 198 IS - 4 N2 - BACKGROUND: The aim of this study was to investigate the clinical characteristics associated with invasive lobular cancer (ILC) and mixed invasive ductal cancer (IDC) and ILC compared with IDC. METHODS: From 1996 to 2006, 4,336 patients with IDC, ILC, and mixed breast cancers were identified. Clinical variables were compared using chi(2) and Fisher's exact tests. Kaplan-Meier survival curves were constructed. RESULTS: Patients included 3,595 (83%) with IDC, 480 (11%) with ILC, and 261 (6%) with mixed cancers. Patients with ILC and mixed cancers were more likely to have low-grade and estrogen-positive and progesterone-positive tumors but were diagnosed at higher stages of disease compared with patients with IDC (P < .05 for each). Patients with IDC had the poorest 5-year (80%) and 10-year (61%) survival compared with patients with ILC (87% and 68%) and mixed (84% and 69%) cancers (P = .029). CONCLUSIONS: Although patients with ILC and "mixed" cancers are diagnosed with more advanced disease, their survival is superior to patients with IDC. SN - 1879-1883 UR - https://www.unboundmedicine.com/medline/citation/19800459/Tumor_characteristics_and_patient_outcomes_are_similar_between_invasive_lobular_and_mixed_invasive_ductal/lobular_breast_cancers_but_differ_from_pure_invasive_ductal_breast_cancers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9610(09)00345-6 DB - PRIME DP - Unbound Medicine ER -