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Pulsar perimetry in the diagnosis of early glaucoma.
Am J Ophthalmol. 2010 Jan; 149(1):102-12.AJ

Abstract

PURPOSE

To assess the ability of Pulsar perimetry (Pulsar) in detecting early glaucomatous visual field (VF) damage in comparison with Frequency Doubling Technology (FDT), Scanning Laser Polarimetry (SLP, GDx VCC), and Heidelberg Retina Tomography (HRT).

DESIGN

Prospective observational cross-sectional case study.

METHODS

This multicenter study included: 87 ocular hypertensives (OHT); 67 glaucomatous optic neuropathy (GON) patients; 75 primary open-angle glaucoma (POAG) patients; and 90 normals. All patients underwent standard automated perimetry (SAP) HFA 30-2, Pulsar T30W, FDT N-30, HRT II, and GDx VCC. Area under Receiver Operating Characteristic Curves (AROCs) for discriminating between healthy and glaucomatous eyes and agreement among instruments were determined.

RESULTS

The best parameters for Pulsar, FDT, HRT, and GDx were, respectively: loss variance square root; no. of areas with P< 5%; Cup-Shape-Measure; and Nerve Fiber Indicator (NFI). In detecting POAG eyes, Pulsar (AROC, 0.90) appeared comparable with FDT (0.89) and significantly better than HRT (0.82) and GDx (0.79). For GON, Pulsar ability (0.74) was higher than GDx (0.69) and lower than FDT (0.80) and HRT (0.83). The agreement among instruments ranged from 0.12 to 0.56. Pulsar test duration was significantly shorter than SAP and FDT (P< .001).

CONCLUSIONS

Pulsar T30W test is a rapid and easy perimetric method, showing higher sensitivity than SAP in detecting early glaucomatous VF loss. Its diagnostic ability is good for detecting early perimetric POAG eyes and fair for GON eyes. Pulsar performance was comparable with FDT, HRT, and GDx, even if the agreement between instruments was poor to fair.

Authors+Show Affiliations

Department of Ophthalmology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

19800607

Citation

Zeppieri, Marco, et al. "Pulsar Perimetry in the Diagnosis of Early Glaucoma." American Journal of Ophthalmology, vol. 149, no. 1, 2010, pp. 102-12.
Zeppieri M, Brusini P, Parisi L, et al. Pulsar perimetry in the diagnosis of early glaucoma. Am J Ophthalmol. 2010;149(1):102-12.
Zeppieri, M., Brusini, P., Parisi, L., Johnson, C. A., Sampaolesi, R., & Salvetat, M. L. (2010). Pulsar perimetry in the diagnosis of early glaucoma. American Journal of Ophthalmology, 149(1), 102-12. https://doi.org/10.1016/j.ajo.2009.07.020
Zeppieri M, et al. Pulsar Perimetry in the Diagnosis of Early Glaucoma. Am J Ophthalmol. 2010;149(1):102-12. PubMed PMID: 19800607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulsar perimetry in the diagnosis of early glaucoma. AU - Zeppieri,Marco, AU - Brusini,Paolo, AU - Parisi,Lucia, AU - Johnson,Chris A, AU - Sampaolesi,Roberto, AU - Salvetat,Maria Letizia, Y1 - 2009/10/02/ PY - 2009/02/18/received PY - 2009/07/16/revised PY - 2009/07/16/accepted PY - 2009/10/6/entrez PY - 2009/10/6/pubmed PY - 2010/2/5/medline SP - 102 EP - 12 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 149 IS - 1 N2 - PURPOSE: To assess the ability of Pulsar perimetry (Pulsar) in detecting early glaucomatous visual field (VF) damage in comparison with Frequency Doubling Technology (FDT), Scanning Laser Polarimetry (SLP, GDx VCC), and Heidelberg Retina Tomography (HRT). DESIGN: Prospective observational cross-sectional case study. METHODS: This multicenter study included: 87 ocular hypertensives (OHT); 67 glaucomatous optic neuropathy (GON) patients; 75 primary open-angle glaucoma (POAG) patients; and 90 normals. All patients underwent standard automated perimetry (SAP) HFA 30-2, Pulsar T30W, FDT N-30, HRT II, and GDx VCC. Area under Receiver Operating Characteristic Curves (AROCs) for discriminating between healthy and glaucomatous eyes and agreement among instruments were determined. RESULTS: The best parameters for Pulsar, FDT, HRT, and GDx were, respectively: loss variance square root; no. of areas with P< 5%; Cup-Shape-Measure; and Nerve Fiber Indicator (NFI). In detecting POAG eyes, Pulsar (AROC, 0.90) appeared comparable with FDT (0.89) and significantly better than HRT (0.82) and GDx (0.79). For GON, Pulsar ability (0.74) was higher than GDx (0.69) and lower than FDT (0.80) and HRT (0.83). The agreement among instruments ranged from 0.12 to 0.56. Pulsar test duration was significantly shorter than SAP and FDT (P< .001). CONCLUSIONS: Pulsar T30W test is a rapid and easy perimetric method, showing higher sensitivity than SAP in detecting early glaucomatous VF loss. Its diagnostic ability is good for detecting early perimetric POAG eyes and fair for GON eyes. Pulsar performance was comparable with FDT, HRT, and GDx, even if the agreement between instruments was poor to fair. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/19800607/Pulsar_perimetry_in_the_diagnosis_of_early_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(09)00518-2 DB - PRIME DP - Unbound Medicine ER -