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Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze.
Behav Brain Res. 2010 Feb 11; 207(1):112-7.BB

Abstract

The L-arginine/nitric oxide (NO)/cGMP pathways have been implicated in the control of a variety of physiological mechanisms and are believed to participate in the modulation of anxiety in the CNS. The aim of this study was to investigate the effects of N(G)-nitro-L-arginine-methyl-ester (L-NAME), a non-selective inhibitor of NO synthase (NOS); 7-nitroindazole (7-NI), a preferential inhibitor of neuronal NOS; and sodium nitroprusside (SNP), an NO donor, administered into the ventral hippocampus (VH) of rats submitted to the elevated T-maze (ETM). The ETM, an animal model derived from the elevated plus-maze, allows the measurement of two defensive behavioral responses in the same rat: inhibitory avoidance and escape. Results showed that L-NAME and 7-NI impaired the acquisition of inhibitory avoidance and prolonged escape latency in the ETM, suggesting an anxiolytic-like and panicolytic-like effect, respectively. SNP facilitated the acquisition of inhibitory avoidance without interfering with escape performance, suggesting an anxiogenic-like effect. Treatment with methylene blue did not alter per se any of the behavioral responses measured in the ETM, but blocked the effect promoted by SNP. Thus, altogether these results suggest that NO in the VH is critically involved in the modulation of defensive behavior of rats exposed to the ETM.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Calixto AV
Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC, Brazil.
Duarte FS
No affiliation info available
Duzzioni M
No affiliation info available
Nascimento Häckl LP
No affiliation info available
Faria MS
No affiliation info available
De Lima TC
No affiliation info available

MeSH

Analysis of VarianceAnimalsAnti-Anxiety AgentsAnxietyAvoidance LearningBehavior, AnimalCyclic GMPDose-Response Relationship, DrugEnzyme InhibitorsEscape ReactionExploratory BehaviorHippocampusIndazolesMaleMethylene BlueMotor ActivityNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide DonorsNitric Oxide SynthaseNitroprussideRatsRats, WistarStaining and Labeling

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19800925

Citation

Calixto, A V., et al. "Role of Ventral Hippocampal Nitric oxide/cGMP Pathway in Anxiety-related Behaviors in Rats Submitted to the Elevated T-maze." Behavioural Brain Research, vol. 207, no. 1, 2010, pp. 112-7.
Calixto AV, Duarte FS, Duzzioni M, et al. Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze. Behav Brain Res. 2010;207(1):112-7.
Calixto, A. V., Duarte, F. S., Duzzioni, M., Nascimento Häckl, L. P., Faria, M. S., & De Lima, T. C. (2010). Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze. Behavioural Brain Research, 207(1), 112-7. https://doi.org/10.1016/j.bbr.2009.09.037
Calixto AV, et al. Role of Ventral Hippocampal Nitric oxide/cGMP Pathway in Anxiety-related Behaviors in Rats Submitted to the Elevated T-maze. Behav Brain Res. 2010 Feb 11;207(1):112-7. PubMed PMID: 19800925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze. AU - Calixto,A V, AU - Duarte,F S, AU - Duzzioni,M, AU - Nascimento Häckl,L P, AU - Faria,M S, AU - De Lima,T C M, Y1 - 2009/10/02/ PY - 2008/8/11/received PY - 2009/9/24/revised PY - 2009/9/27/accepted PY - 2009/10/6/entrez PY - 2009/10/6/pubmed PY - 2010/1/15/medline SP - 112 EP - 7 JF - Behavioural brain research JO - Behav Brain Res VL - 207 IS - 1 N2 - The L-arginine/nitric oxide (NO)/cGMP pathways have been implicated in the control of a variety of physiological mechanisms and are believed to participate in the modulation of anxiety in the CNS. The aim of this study was to investigate the effects of N(G)-nitro-L-arginine-methyl-ester (L-NAME), a non-selective inhibitor of NO synthase (NOS); 7-nitroindazole (7-NI), a preferential inhibitor of neuronal NOS; and sodium nitroprusside (SNP), an NO donor, administered into the ventral hippocampus (VH) of rats submitted to the elevated T-maze (ETM). The ETM, an animal model derived from the elevated plus-maze, allows the measurement of two defensive behavioral responses in the same rat: inhibitory avoidance and escape. Results showed that L-NAME and 7-NI impaired the acquisition of inhibitory avoidance and prolonged escape latency in the ETM, suggesting an anxiolytic-like and panicolytic-like effect, respectively. SNP facilitated the acquisition of inhibitory avoidance without interfering with escape performance, suggesting an anxiogenic-like effect. Treatment with methylene blue did not alter per se any of the behavioral responses measured in the ETM, but blocked the effect promoted by SNP. Thus, altogether these results suggest that NO in the VH is critically involved in the modulation of defensive behavior of rats exposed to the ETM. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19800925/Role_of_ventral_hippocampal_nitric_oxide/cGMP_pathway_in_anxiety_related_behaviors_in_rats_submitted_to_the_elevated_T_maze_ DB - PRIME DP - Unbound Medicine ER -