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Exogenous somatostatin raises plasma insulin levels in patients with insulin-dependent diabetes mellitus.
Horm Metab Res. 1990 Nov; 22(11):581-3.HM

Abstract

The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i.v. insulin substitution for 18 hours. A constant rate i.v. insulin infusion (0.4 mU/kg/min) was given for 240 min and somatostatin was co-infused between 60-120 min (100 micrograms/h) and 180-240 min (250 micrograms/h) respectively. Plasma insulin, blood glucose and hematocrit were measured at 15 min intervals. Hematocrit fell from 41.7 to 38.3% during the study period. Somatostatin increased the plasma insulin levels, corrected for the changes of hematocrit, by approximately 8% in the low dose (P less than 0.05) as well as in the high dose (P less than 0.05) period. It is concluded that somatostatin interferes with the clearance of insulin thereby increasing the circulating plasma insulin levels in IDDM patients without residual insulin secretion.

Authors+Show Affiliations

Kollind M
Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden.
Moberg E
No affiliation info available
Lins PE
No affiliation info available
Adamson U
No affiliation info available

MeSH

AdultBlood GlucoseDiabetes Mellitus, Type 1FemaleHematocritHumansInsulinKineticsMaleSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1980258

Citation

Kollind, M, et al. "Exogenous Somatostatin Raises Plasma Insulin Levels in Patients With Insulin-dependent Diabetes Mellitus." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 22, no. 11, 1990, pp. 581-3.
Kollind M, Moberg E, Lins PE, et al. Exogenous somatostatin raises plasma insulin levels in patients with insulin-dependent diabetes mellitus. Horm Metab Res. 1990;22(11):581-3.
Kollind, M., Moberg, E., Lins, P. E., & Adamson, U. (1990). Exogenous somatostatin raises plasma insulin levels in patients with insulin-dependent diabetes mellitus. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 22(11), 581-3.
Kollind M, et al. Exogenous Somatostatin Raises Plasma Insulin Levels in Patients With Insulin-dependent Diabetes Mellitus. Horm Metab Res. 1990;22(11):581-3. PubMed PMID: 1980258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exogenous somatostatin raises plasma insulin levels in patients with insulin-dependent diabetes mellitus. AU - Kollind,M, AU - Moberg,E, AU - Lins,P E, AU - Adamson,U, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 581 EP - 3 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 22 IS - 11 N2 - The effect of cyclic somatostatin on circulating insulin levels was studied in eight patients with insulin-dependent diabetes mellitus (IDDM). The study was performed after an overnight fast when their subcutaneous depots of insulin had been depleted during i.v. insulin substitution for 18 hours. A constant rate i.v. insulin infusion (0.4 mU/kg/min) was given for 240 min and somatostatin was co-infused between 60-120 min (100 micrograms/h) and 180-240 min (250 micrograms/h) respectively. Plasma insulin, blood glucose and hematocrit were measured at 15 min intervals. Hematocrit fell from 41.7 to 38.3% during the study period. Somatostatin increased the plasma insulin levels, corrected for the changes of hematocrit, by approximately 8% in the low dose (P less than 0.05) as well as in the high dose (P less than 0.05) period. It is concluded that somatostatin interferes with the clearance of insulin thereby increasing the circulating plasma insulin levels in IDDM patients without residual insulin secretion. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/1980258/Exogenous_somatostatin_raises_plasma_insulin_levels_in_patients_with_insulin_dependent_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -