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The worm solution: a chromosome-full of condensin helps gene expression go down.
Chromosome Res 2009; 17(5):621-35CR

Abstract

Dosage compensation in the nematode Caenorhabditis elegans is achieved by the binding of a condensin-like dosage compensation complex (DCC) to both X chromosomes in hermaphrodites to downregulate gene expression two-fold. Condensin I(DC), a sub-part of the DCC, differs from the mitotic condensin I complex by a single subunit, strengthening the connection between dosage compensation and mitotic chromosome condensation. The DCC is targeted to X chromosomes by initial binding to a number of recruiting elements, followed by dispersal or spreading to secondary sites. While the complex is greatly enriched on the X chromosomes, many sites on autosomes also bind the complex. DCC binding does not correlate with DCC-mediated repression, suggesting that the complex acts in a chromosome-wide manner, rather than on a gene-by-gene basis. Worm dosage compensation represents an excellent model system to study how condensin-mediated changes in higher order chromatin organization affect gene expression.

Authors+Show Affiliations

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. gyorgyi@umich.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19802703

Citation

Csankovszki, Györgyi, et al. "The Worm Solution: a Chromosome-full of Condensin Helps Gene Expression Go Down." Chromosome Research : an International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology, vol. 17, no. 5, 2009, pp. 621-35.
Csankovszki G, Petty EL, Collette KS. The worm solution: a chromosome-full of condensin helps gene expression go down. Chromosome Res. 2009;17(5):621-35.
Csankovszki, G., Petty, E. L., & Collette, K. S. (2009). The worm solution: a chromosome-full of condensin helps gene expression go down. Chromosome Research : an International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology, 17(5), pp. 621-35. doi:10.1007/s10577-009-9061-y.
Csankovszki G, Petty EL, Collette KS. The Worm Solution: a Chromosome-full of Condensin Helps Gene Expression Go Down. Chromosome Res. 2009;17(5):621-35. PubMed PMID: 19802703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The worm solution: a chromosome-full of condensin helps gene expression go down. AU - Csankovszki,Györgyi, AU - Petty,Emily L, AU - Collette,Karishma S, PY - 2009/10/6/entrez PY - 2009/10/6/pubmed PY - 2009/12/16/medline SP - 621 EP - 35 JF - Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology JO - Chromosome Res. VL - 17 IS - 5 N2 - Dosage compensation in the nematode Caenorhabditis elegans is achieved by the binding of a condensin-like dosage compensation complex (DCC) to both X chromosomes in hermaphrodites to downregulate gene expression two-fold. Condensin I(DC), a sub-part of the DCC, differs from the mitotic condensin I complex by a single subunit, strengthening the connection between dosage compensation and mitotic chromosome condensation. The DCC is targeted to X chromosomes by initial binding to a number of recruiting elements, followed by dispersal or spreading to secondary sites. While the complex is greatly enriched on the X chromosomes, many sites on autosomes also bind the complex. DCC binding does not correlate with DCC-mediated repression, suggesting that the complex acts in a chromosome-wide manner, rather than on a gene-by-gene basis. Worm dosage compensation represents an excellent model system to study how condensin-mediated changes in higher order chromatin organization affect gene expression. SN - 1573-6849 UR - https://www.unboundmedicine.com/medline/citation/19802703/The_worm_solution:_a_chromosome_full_of_condensin_helps_gene_expression_go_down_ L2 - https://doi.org/10.1007/s10577-009-9061-y DB - PRIME DP - Unbound Medicine ER -