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Influence of heavy cigarette smoking on heart rate variability and heart rate turbulence parameters.
Ann Noninvasive Electrocardiol 2009; 14(4):327-32AN

Abstract

BACKGROUND

Cigarette smoking increases the risk of cardiovascular events related with several mechanisms. The most suggested mechanism is increased activity of sympathetic nervous system. Heart rate variability (HRV) and heart rate turbulence (HRT) has been shown to be independent and powerful predictors of mortality in a specific group of cardiac patients. The goal of this study was to assess the effect of heavy cigarette smoking on cardiac autonomic function using HRV and HRT analyses.

METHODS

Heavy cigarette smoking was defined as more than 20 cigarettes smoked per day. Heavy cigarette smokers, 69 subjects and nonsmokers 74 subjects (control group) were enrolled in this study. HRV and HRT analyses [turbulence onset (TO) and turbulence slope (TS)] were assessed from 24-hour Holter recordings.

RESULTS

The values of TO were significantly higher in heavy cigarette smokers than control group (-1.150 +/- 4.007 vs -2.454 +/- 2.796, P = 0.025, respectively), but values of TS were not statistically different between two groups (10.352 +/- 7.670 vs 9.613 +/- 7.245, P = 0.555, respectively). Also, the number of patients who had abnormal TO was significantly higher in heavy cigarette smokers than control group (23 vs 10, P = 0.006). TO was correlated with the number of cigarettes smoked per day (r = 0.235, P = 0.004). While LF and LF/HF ratio were significantly higher, standard deviation of all NN intervals (SDNN), standard deviation of the 5-minute mean RR intervals (SDANN), root mean square of successive differences (RMSSD), and high-frequency (HF) values were significantly lower in heavy smokers. While, there was significant correlation between TO and SDNN, SDANN, RMSSD, LF, and high frequency (HF), only HF was correlated with TS.

CONCLUSION

Heavy cigarette smoking has negative effect on autonomic function. HRT is an appropriate noninvasive method to evaluate the effect of cigarette on autonomic function. Simultaneous abnormal HRT and HRV values may explain increased cardiovascular event risk in heavy cigarette smokers.

Authors+Show Affiliations

Department of Cardiology, Ministry of Health Dişkapi Yildirim Beyazit Research and Educational Hospital, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19804508

Citation

Cagirci, Goksel, et al. "Influence of Heavy Cigarette Smoking On Heart Rate Variability and Heart Rate Turbulence Parameters." Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, vol. 14, no. 4, 2009, pp. 327-32.
Cagirci G, Cay S, Karakurt O, et al. Influence of heavy cigarette smoking on heart rate variability and heart rate turbulence parameters. Ann Noninvasive Electrocardiol. 2009;14(4):327-32.
Cagirci, G., Cay, S., Karakurt, O., Eryasar, N., Kaya, V., Canga, A., ... Akdemir, R. (2009). Influence of heavy cigarette smoking on heart rate variability and heart rate turbulence parameters. Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 14(4), pp. 327-32. doi:10.1111/j.1542-474X.2009.00321.x.
Cagirci G, et al. Influence of Heavy Cigarette Smoking On Heart Rate Variability and Heart Rate Turbulence Parameters. Ann Noninvasive Electrocardiol. 2009;14(4):327-32. PubMed PMID: 19804508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of heavy cigarette smoking on heart rate variability and heart rate turbulence parameters. AU - Cagirci,Goksel, AU - Cay,Serkan, AU - Karakurt,Ozlem, AU - Eryasar,Neslihan, AU - Kaya,Veli, AU - Canga,Aytun, AU - Yesilay,Asuman Bicer, AU - Kilic,Harun, AU - Topaloglu,Serkan, AU - Aras,Dursun, AU - Demir,Ahmet Duran, AU - Akdemir,Ramazan, PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2010/1/5/medline SP - 327 EP - 32 JF - Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc JO - Ann Noninvasive Electrocardiol VL - 14 IS - 4 N2 - BACKGROUND: Cigarette smoking increases the risk of cardiovascular events related with several mechanisms. The most suggested mechanism is increased activity of sympathetic nervous system. Heart rate variability (HRV) and heart rate turbulence (HRT) has been shown to be independent and powerful predictors of mortality in a specific group of cardiac patients. The goal of this study was to assess the effect of heavy cigarette smoking on cardiac autonomic function using HRV and HRT analyses. METHODS: Heavy cigarette smoking was defined as more than 20 cigarettes smoked per day. Heavy cigarette smokers, 69 subjects and nonsmokers 74 subjects (control group) were enrolled in this study. HRV and HRT analyses [turbulence onset (TO) and turbulence slope (TS)] were assessed from 24-hour Holter recordings. RESULTS: The values of TO were significantly higher in heavy cigarette smokers than control group (-1.150 +/- 4.007 vs -2.454 +/- 2.796, P = 0.025, respectively), but values of TS were not statistically different between two groups (10.352 +/- 7.670 vs 9.613 +/- 7.245, P = 0.555, respectively). Also, the number of patients who had abnormal TO was significantly higher in heavy cigarette smokers than control group (23 vs 10, P = 0.006). TO was correlated with the number of cigarettes smoked per day (r = 0.235, P = 0.004). While LF and LF/HF ratio were significantly higher, standard deviation of all NN intervals (SDNN), standard deviation of the 5-minute mean RR intervals (SDANN), root mean square of successive differences (RMSSD), and high-frequency (HF) values were significantly lower in heavy smokers. While, there was significant correlation between TO and SDNN, SDANN, RMSSD, LF, and high frequency (HF), only HF was correlated with TS. CONCLUSION: Heavy cigarette smoking has negative effect on autonomic function. HRT is an appropriate noninvasive method to evaluate the effect of cigarette on autonomic function. Simultaneous abnormal HRT and HRV values may explain increased cardiovascular event risk in heavy cigarette smokers. SN - 1542-474X UR - https://www.unboundmedicine.com/medline/citation/19804508/Influence_of_heavy_cigarette_smoking_on_heart_rate_variability_and_heart_rate_turbulence_parameters_ L2 - https://doi.org/10.1111/j.1542-474X.2009.00321.x DB - PRIME DP - Unbound Medicine ER -