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Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients.
Tissue Antigens. 2010 Jan; 75(1):61-4.TA

Abstract

The HLA-B27 subtypes have a varied racial and ethnic prevalence throughout the world. However, the association of B27-subtypes with ankylosing spondylitis (AS) in the mainland China is unknown. To determine the association of B27-subtypes with AS in the Mainland Chinese Han population, a total of unrelated 153 patients with AS were enrolled in a large case-control association study, and 1545 unrelated, healthy, ethnically matched blood donors were included as controls. The genotyping of B27 and its subtypes was performed using the polymerase chain reaction with sequence specific primers (PCR-SSP). A total of 130 (84.97%) AS patients and 61 (3.95%) healthy controls were B27 positive. Three B27-subtypes, B*2704, B*2705 and B*2710, were further identified, of which both B*2704 and B*2705 were strongly AS associated. B*2710 was only detected in one AS patient and two other healthy controls. Considering only B27-positive cases and controls, a statistically different frequency of B27-subtypes was observed, with an over-representation of B*2704 (P = 0.018). B*2704 was clearly more strongly associated than B*2705 with AS [odds ratio (OR) = 2.4, P = 0.011]. Furthermore, a combined analysis including three previous studies of B27-subtype distributions in Chinese AS cases confirmed the stronger association of B*2704 with AS than B*2705 (OR = 2.5, P = 0.00094).

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Authors+Show Affiliations

Liu Y
Department of Rheumatology and Immunology, Changzheng Hospital, The Second Military Medical University, Shanghai, China.
Jiang L
No affiliation info available
Cai Q
No affiliation info available
Danoy P
No affiliation info available
Barnardo MC
No affiliation info available
Brown MA
No affiliation info available
Xu H
No affiliation info available

MeSH

Asian Continental Ancestry GroupCase-Control StudiesChinaGenetic Association StudiesGenetic Predisposition to DiseaseHLA-B27 AntigenHumansSpondylitis, Ankylosing

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19804562

Citation

Liu, Y, et al. "Predominant Association of HLA-B*2704 With Ankylosing Spondylitis in Chinese Han Patients." Tissue Antigens, vol. 75, no. 1, 2010, pp. 61-4.
Liu Y, Jiang L, Cai Q, et al. Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. Tissue Antigens. 2010;75(1):61-4.
Liu, Y., Jiang, L., Cai, Q., Danoy, P., Barnardo, M. C., Brown, M. A., & Xu, H. (2010). Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. Tissue Antigens, 75(1), 61-4. https://doi.org/10.1111/j.1399-0039.2009.01379.x
Liu Y, et al. Predominant Association of HLA-B*2704 With Ankylosing Spondylitis in Chinese Han Patients. Tissue Antigens. 2010;75(1):61-4. PubMed PMID: 19804562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. AU - Liu,Y, AU - Jiang,L, AU - Cai,Q, AU - Danoy,P, AU - Barnardo,M C N M, AU - Brown,M A, AU - Xu,H, Y1 - 2009/10/04/ PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2010/8/6/medline SP - 61 EP - 4 JF - Tissue antigens JO - Tissue Antigens VL - 75 IS - 1 N2 - The HLA-B27 subtypes have a varied racial and ethnic prevalence throughout the world. However, the association of B27-subtypes with ankylosing spondylitis (AS) in the mainland China is unknown. To determine the association of B27-subtypes with AS in the Mainland Chinese Han population, a total of unrelated 153 patients with AS were enrolled in a large case-control association study, and 1545 unrelated, healthy, ethnically matched blood donors were included as controls. The genotyping of B27 and its subtypes was performed using the polymerase chain reaction with sequence specific primers (PCR-SSP). A total of 130 (84.97%) AS patients and 61 (3.95%) healthy controls were B27 positive. Three B27-subtypes, B*2704, B*2705 and B*2710, were further identified, of which both B*2704 and B*2705 were strongly AS associated. B*2710 was only detected in one AS patient and two other healthy controls. Considering only B27-positive cases and controls, a statistically different frequency of B27-subtypes was observed, with an over-representation of B*2704 (P = 0.018). B*2704 was clearly more strongly associated than B*2705 with AS [odds ratio (OR) = 2.4, P = 0.011]. Furthermore, a combined analysis including three previous studies of B27-subtype distributions in Chinese AS cases confirmed the stronger association of B*2704 with AS than B*2705 (OR = 2.5, P = 0.00094). SN - 1399-0039 UR - https://www.unboundmedicine.com/medline/citation/19804562/Predominant_association_of_HLA_B_2704_with_ankylosing_spondylitis_in_Chinese_Han_patients_ L2 - https://doi.org/10.1111/j.1399-0039.2009.01379.x DB - PRIME DP - Unbound Medicine ER -