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Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice.
Ecotoxicol Environ Saf. 1990 Oct; 20(2):175-84.EE

Abstract

Toluene, a potentially neurotoxic substance, is found in trace amounts in groundwater. Adult male CD-1 mice were continuously fed drinking water ad libitum containing 0, 17, 80, and 405 mg/liter toluene. After a 28-day treatment, animals were tested for endogenous levels of the biogenic monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and their respective metabolites. 3-methoxy-4-hydroxymandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), in six discrete brain regions. The maximum toluene-induced increases of biogenic amines and their metabolites generally occurred at a toluene concentration of 80 mg/liter. In the hypothalamus, a major NE-containing compartment, the concentrations of NE significantly increased by 51, 63, and 34% in groups dosed with 17, 80, and 405 mg/liter, respectively. Significant increases of NE were also observed in the medulla oblongata and midbrain. Concomitantly, concentrations of VMA increased in various brain regions. Concentrations of DA were significantly higher in the corpus striatum and hypothalamus. Alterations in levels of DA metabolites, DOPAC and HVA, were marginal. Toluene significantly increased concentrations of 5-HT in all dissected brain regions, except cerebellum, and increased the 5-HIAA levels in the hypothalamus, corpus striatum, and cerebral cortex.

Authors+Show Affiliations

Hsieh GC
Department of Biology, Utah State University, Logan 84322.
Sharma RP
No affiliation info available
Parker RD
No affiliation info available
Coulombe RA
No affiliation info available

MeSH

AnimalsBiogenic MonoaminesBrain ChemistryCerebellumCerebral CortexChromatography, GasCorpus StriatumMaleMesencephalonMiceMice, Inbred StrainsNeurotransmitter AgentsTolueneWater Pollutants, ChemicalWater Supply

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1980457

Citation

Hsieh, G C., et al. "Evaluation of Toluene Exposure Via Drinking Water On Levels of Regional Brain Biogenic Monoamines and Their Metabolites in CD-1 Mice." Ecotoxicology and Environmental Safety, vol. 20, no. 2, 1990, pp. 175-84.
Hsieh GC, Sharma RP, Parker RD, et al. Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice. Ecotoxicol Environ Saf. 1990;20(2):175-84.
Hsieh, G. C., Sharma, R. P., Parker, R. D., & Coulombe, R. A. (1990). Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice. Ecotoxicology and Environmental Safety, 20(2), 175-84.
Hsieh GC, et al. Evaluation of Toluene Exposure Via Drinking Water On Levels of Regional Brain Biogenic Monoamines and Their Metabolites in CD-1 Mice. Ecotoxicol Environ Saf. 1990;20(2):175-84. PubMed PMID: 1980457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice. AU - Hsieh,G C, AU - Sharma,R P, AU - Parker,R D, AU - Coulombe,R A,Jr PY - 1990/10/11/pubmed PY - 2001/3/28/medline PY - 1990/10/11/entrez SP - 175 EP - 84 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 20 IS - 2 N2 - Toluene, a potentially neurotoxic substance, is found in trace amounts in groundwater. Adult male CD-1 mice were continuously fed drinking water ad libitum containing 0, 17, 80, and 405 mg/liter toluene. After a 28-day treatment, animals were tested for endogenous levels of the biogenic monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and their respective metabolites. 3-methoxy-4-hydroxymandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), in six discrete brain regions. The maximum toluene-induced increases of biogenic amines and their metabolites generally occurred at a toluene concentration of 80 mg/liter. In the hypothalamus, a major NE-containing compartment, the concentrations of NE significantly increased by 51, 63, and 34% in groups dosed with 17, 80, and 405 mg/liter, respectively. Significant increases of NE were also observed in the medulla oblongata and midbrain. Concomitantly, concentrations of VMA increased in various brain regions. Concentrations of DA were significantly higher in the corpus striatum and hypothalamus. Alterations in levels of DA metabolites, DOPAC and HVA, were marginal. Toluene significantly increased concentrations of 5-HT in all dissected brain regions, except cerebellum, and increased the 5-HIAA levels in the hypothalamus, corpus striatum, and cerebral cortex. SN - 0147-6513 UR - https://www.unboundmedicine.com/medline/citation/1980457/Evaluation_of_toluene_exposure_via_drinking_water_on_levels_of_regional_brain_biogenic_monoamines_and_their_metabolites_in_CD_1_mice_ DB - PRIME DP - Unbound Medicine ER -