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Characterization of a highly pathogenic avian influenza H5N1 clade 2.3.4 virus isolated from a tree sparrow.
Virus Res. 2010 Jan; 147(1):25-9.VR

Abstract

The spread of H5N1 virus into a wide range of avian and mammalian species may facilitate the adaptation of the virus to human populations. In the present study, a survey of avian influenza virus in tree sparrows was performed and a HPAI H5N1 virus (A/tree sparrow/Jiangsu/1/08) was isolated. The H5N1 virus was found to be a genotype V variant belonging to clade 2.3.4, which had newly emerged in southern China in 2005. Genetic analysis showed that it had a close relation with A/Jiangsu/1/07 (H5N1), which was thought to be responsible for a probable limited person-to-person transmission in a family cluster in China in 2007. Pathogencity studies showed that the virus was highly virulent when experimentally inoculated into the chickens, tree sparrow, and mouse. As clade 2.3.4, genotype V variant of H5N1 virus has been accounted for the most of human fatal cases in China during 2005-2008, the existence of such H5N1 variants in the tree sparrows highlights the potential threat of this type of wild bird infection to veterinary and public health.

Authors+Show Affiliations

Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19804800

Citation

Liu, Qinfang, et al. "Characterization of a Highly Pathogenic Avian Influenza H5N1 Clade 2.3.4 Virus Isolated From a Tree Sparrow." Virus Research, vol. 147, no. 1, 2010, pp. 25-9.
Liu Q, Ma J, Kou Z, et al. Characterization of a highly pathogenic avian influenza H5N1 clade 2.3.4 virus isolated from a tree sparrow. Virus Res. 2010;147(1):25-9.
Liu, Q., Ma, J., Kou, Z., Pu, J., Lei, F., Li, T., & Liu, J. (2010). Characterization of a highly pathogenic avian influenza H5N1 clade 2.3.4 virus isolated from a tree sparrow. Virus Research, 147(1), 25-9. https://doi.org/10.1016/j.virusres.2009.09.014
Liu Q, et al. Characterization of a Highly Pathogenic Avian Influenza H5N1 Clade 2.3.4 Virus Isolated From a Tree Sparrow. Virus Res. 2010;147(1):25-9. PubMed PMID: 19804800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of a highly pathogenic avian influenza H5N1 clade 2.3.4 virus isolated from a tree sparrow. AU - Liu,Qinfang, AU - Ma,Jingjiao, AU - Kou,Zheng, AU - Pu,Juan, AU - Lei,Fumin, AU - Li,Tianxian, AU - Liu,Jinhua, Y1 - 2009/10/03/ PY - 2009/06/22/received PY - 2009/09/24/revised PY - 2009/09/25/accepted PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2010/2/4/medline SP - 25 EP - 9 JF - Virus research JO - Virus Res VL - 147 IS - 1 N2 - The spread of H5N1 virus into a wide range of avian and mammalian species may facilitate the adaptation of the virus to human populations. In the present study, a survey of avian influenza virus in tree sparrows was performed and a HPAI H5N1 virus (A/tree sparrow/Jiangsu/1/08) was isolated. The H5N1 virus was found to be a genotype V variant belonging to clade 2.3.4, which had newly emerged in southern China in 2005. Genetic analysis showed that it had a close relation with A/Jiangsu/1/07 (H5N1), which was thought to be responsible for a probable limited person-to-person transmission in a family cluster in China in 2007. Pathogencity studies showed that the virus was highly virulent when experimentally inoculated into the chickens, tree sparrow, and mouse. As clade 2.3.4, genotype V variant of H5N1 virus has been accounted for the most of human fatal cases in China during 2005-2008, the existence of such H5N1 variants in the tree sparrows highlights the potential threat of this type of wild bird infection to veterinary and public health. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/19804800/Characterization_of_a_highly_pathogenic_avian_influenza_H5N1_clade_2_3_4_virus_isolated_from_a_tree_sparrow_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(09)00348-7 DB - PRIME DP - Unbound Medicine ER -