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Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort.
Arch Gen Psychiatry. 2009 Oct; 66(10):1090-8.AG

Abstract

CONTEXT

Adherence to the Mediterranean dietary pattern (MDP) is thought to reduce inflammatory, vascular, and metabolic processes that may be involved in the risk of clinical depression.

OBJECTIVE

To assess the association between adherence to the MDP and the incidence of clinical depression.

DESIGN

Prospective study that uses a validated 136-item food frequency questionnaire to assess adherence to the MDP. The MDP score positively weighted the consumption of vegetables, fruit and nuts, cereal, legumes, and fish; the monounsaturated- to saturated-fatty-acids ratio; and moderate alcohol consumption, whereas meat or meat products and whole-fat dairy were negatively weighted.

SETTING

A dynamic cohort of university graduates (Seguimiento Universidad de Navarra/University of Navarra Follow-up [SUN] Project).

PARTICIPANTS

A total of 10 094 initially healthy Spanish participants from the SUN Project participated in the study. Recruitment began on December 21, 1999, and is ongoing.

MAIN OUTCOME MEASURE

Participants were classified as having incident depression if they were free of depression and antidepressant medication at baseline and reported a physician-made diagnosis of clinical depression and/or antidepressant medication use during follow-up.

RESULTS

After a median follow-up of 4.4 years, 480 new cases of depression were identified. The multiple adjusted hazard ratios (95% confidence intervals) of depression for the 4 upper successive categories of adherence to the MDP (taking the category of lowest adherence as reference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67), and 0.58 (0.44-0.77) (P for trend <.001). Inverse dose-response relationships were found for fruit and nuts, the monounsaturated- to saturated-fatty-acids ratio, and legumes.

CONCLUSIONS

Our results suggest a potential protective role of the MDP with regard to the prevention of depressive disorders; additional longitudinal studies and trials are needed to confirm these findings.

Authors+Show Affiliations

Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19805699

Citation

Sánchez-Villegas, Almudena, et al. "Association of the Mediterranean Dietary Pattern With the Incidence of Depression: the Seguimiento Universidad De Navarra/University of Navarra Follow-up (SUN) Cohort." Archives of General Psychiatry, vol. 66, no. 10, 2009, pp. 1090-8.
Sánchez-Villegas A, Delgado-Rodríguez M, Alonso A, et al. Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry. 2009;66(10):1090-8.
Sánchez-Villegas, A., Delgado-Rodríguez, M., Alonso, A., Schlatter, J., Lahortiga, F., Serra Majem, L., & Martínez-González, M. A. (2009). Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Archives of General Psychiatry, 66(10), 1090-8. https://doi.org/10.1001/archgenpsychiatry.2009.129
Sánchez-Villegas A, et al. Association of the Mediterranean Dietary Pattern With the Incidence of Depression: the Seguimiento Universidad De Navarra/University of Navarra Follow-up (SUN) Cohort. Arch Gen Psychiatry. 2009;66(10):1090-8. PubMed PMID: 19805699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. AU - Sánchez-Villegas,Almudena, AU - Delgado-Rodríguez,Miguel, AU - Alonso,Alvaro, AU - Schlatter,Javier, AU - Lahortiga,Francisca, AU - Serra Majem,Lluis, AU - Martínez-González,Miguel Angel, PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2009/10/14/medline SP - 1090 EP - 8 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 66 IS - 10 N2 - CONTEXT: Adherence to the Mediterranean dietary pattern (MDP) is thought to reduce inflammatory, vascular, and metabolic processes that may be involved in the risk of clinical depression. OBJECTIVE: To assess the association between adherence to the MDP and the incidence of clinical depression. DESIGN: Prospective study that uses a validated 136-item food frequency questionnaire to assess adherence to the MDP. The MDP score positively weighted the consumption of vegetables, fruit and nuts, cereal, legumes, and fish; the monounsaturated- to saturated-fatty-acids ratio; and moderate alcohol consumption, whereas meat or meat products and whole-fat dairy were negatively weighted. SETTING: A dynamic cohort of university graduates (Seguimiento Universidad de Navarra/University of Navarra Follow-up [SUN] Project). PARTICIPANTS: A total of 10 094 initially healthy Spanish participants from the SUN Project participated in the study. Recruitment began on December 21, 1999, and is ongoing. MAIN OUTCOME MEASURE: Participants were classified as having incident depression if they were free of depression and antidepressant medication at baseline and reported a physician-made diagnosis of clinical depression and/or antidepressant medication use during follow-up. RESULTS: After a median follow-up of 4.4 years, 480 new cases of depression were identified. The multiple adjusted hazard ratios (95% confidence intervals) of depression for the 4 upper successive categories of adherence to the MDP (taking the category of lowest adherence as reference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67), and 0.58 (0.44-0.77) (P for trend <.001). Inverse dose-response relationships were found for fruit and nuts, the monounsaturated- to saturated-fatty-acids ratio, and legumes. CONCLUSIONS: Our results suggest a potential protective role of the MDP with regard to the prevention of depressive disorders; additional longitudinal studies and trials are needed to confirm these findings. SN - 1538-3636 UR - https://www.unboundmedicine.com/medline/citation/19805699/Association_of_the_Mediterranean_dietary_pattern_with_the_incidence_of_depression:_the_Seguimiento_Universidad_de_Navarra/University_of_Navarra_follow_up__SUN__cohort_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=19805699.ui DB - PRIME DP - Unbound Medicine ER -