Tags

Type your tag names separated by a space and hit enter

Characteristics and concordance of autism spectrum disorders among 277 twin pairs.
Arch Pediatr Adolesc Med 2009; 163(10):907-14AP

Abstract

OBJECTIVES

To examine patterns of autism spectrum disorder (ASD) inheritance and other features in twin pairs by zygosity, sex, and specific ASD diagnosis.

DESIGN

Cross-sectional study.

SETTING

Internet-based autism registry for US residents.

PARTICIPANTS

Survey results from 277 twin pairs (210 dizygotic [DZ] and 67 monozygotic [MZ]) aged 18 years or younger with at least 1 affected twin.

MAIN EXPOSURES

Zygosity and sex.

OUTCOME MEASURES

Concordance within twin pairs of diagnosis, natural history, and results from standardized autism screening.

RESULTS

Pairwise ASD concordance was 31% for DZ and 88% for MZ twins. Female and male MZ twins were 100% and 86% concordant, respectively, and DZ twin pairs with at least 1 female were less likely to be concordant (20%) than were male-male DZ twin pairs (40%). The hazard ratio for ASD diagnosis of the second twin after a first-twin diagnosis was 7.48 for MZ vs DZ twins (95% confidence interval, 3.8-14.7). Affected DZ individual twins had an earlier age at first parental concern and more frequent diagnoses of intellectual disability than did MZ twins; MZ twins had a higher prevalence of bipolar disorder and Asperger syndrome and higher concordance of the latter. Results of autism screening correlated with parent-reported ASD status in more than 90% of cases.

CONCLUSIONS

Our data support greater ASD concordance in MZ vs DZ twins. Overall higher functioning, psychiatric comorbidity, and Asperger syndrome concordance among affected MZ vs DZ twins may also suggest differential heritability for different ASDs. For families in which one MZ twin is diagnosed with ASD, the second twin is unlikely to receive an ASD diagnosis after 12 months. In addition, Internet parent report of ASD status is valid.

Authors+Show Affiliations

Department of Medical Informatics, Kennedy Krieger Institute, Baltimore, MD 21211, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

19805709

Citation

Rosenberg, Rebecca E., et al. "Characteristics and Concordance of Autism Spectrum Disorders Among 277 Twin Pairs." Archives of Pediatrics & Adolescent Medicine, vol. 163, no. 10, 2009, pp. 907-14.
Rosenberg RE, Law JK, Yenokyan G, et al. Characteristics and concordance of autism spectrum disorders among 277 twin pairs. Arch Pediatr Adolesc Med. 2009;163(10):907-14.
Rosenberg, R. E., Law, J. K., Yenokyan, G., McGready, J., Kaufmann, W. E., & Law, P. A. (2009). Characteristics and concordance of autism spectrum disorders among 277 twin pairs. Archives of Pediatrics & Adolescent Medicine, 163(10), pp. 907-14. doi:10.1001/archpediatrics.2009.98.
Rosenberg RE, et al. Characteristics and Concordance of Autism Spectrum Disorders Among 277 Twin Pairs. Arch Pediatr Adolesc Med. 2009;163(10):907-14. PubMed PMID: 19805709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics and concordance of autism spectrum disorders among 277 twin pairs. AU - Rosenberg,Rebecca E, AU - Law,J Kiely, AU - Yenokyan,Gayane, AU - McGready,John, AU - Kaufmann,Walter E, AU - Law,Paul A, PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2009/10/27/medline SP - 907 EP - 14 JF - Archives of pediatrics & adolescent medicine JO - Arch Pediatr Adolesc Med VL - 163 IS - 10 N2 - OBJECTIVES: To examine patterns of autism spectrum disorder (ASD) inheritance and other features in twin pairs by zygosity, sex, and specific ASD diagnosis. DESIGN: Cross-sectional study. SETTING: Internet-based autism registry for US residents. PARTICIPANTS: Survey results from 277 twin pairs (210 dizygotic [DZ] and 67 monozygotic [MZ]) aged 18 years or younger with at least 1 affected twin. MAIN EXPOSURES: Zygosity and sex. OUTCOME MEASURES: Concordance within twin pairs of diagnosis, natural history, and results from standardized autism screening. RESULTS: Pairwise ASD concordance was 31% for DZ and 88% for MZ twins. Female and male MZ twins were 100% and 86% concordant, respectively, and DZ twin pairs with at least 1 female were less likely to be concordant (20%) than were male-male DZ twin pairs (40%). The hazard ratio for ASD diagnosis of the second twin after a first-twin diagnosis was 7.48 for MZ vs DZ twins (95% confidence interval, 3.8-14.7). Affected DZ individual twins had an earlier age at first parental concern and more frequent diagnoses of intellectual disability than did MZ twins; MZ twins had a higher prevalence of bipolar disorder and Asperger syndrome and higher concordance of the latter. Results of autism screening correlated with parent-reported ASD status in more than 90% of cases. CONCLUSIONS: Our data support greater ASD concordance in MZ vs DZ twins. Overall higher functioning, psychiatric comorbidity, and Asperger syndrome concordance among affected MZ vs DZ twins may also suggest differential heritability for different ASDs. For families in which one MZ twin is diagnosed with ASD, the second twin is unlikely to receive an ASD diagnosis after 12 months. In addition, Internet parent report of ASD status is valid. SN - 1538-3628 UR - https://www.unboundmedicine.com/medline/citation/19805709/Characteristics_and_concordance_of_autism_spectrum_disorders_among_277_twin_pairs_ L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/archpediatrics.2009.98 DB - PRIME DP - Unbound Medicine ER -